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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:103.6 nTPM
HPA:103.6 nTPM
GTEx:119.6 nTPM
FANTOM5:45.9 Scaled Tags Per Million
Pig:38.5 nTPM
Mouse:34.4 nTPM
Allen mouse:5.9 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 103.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 98.3
2586 Male, age 75, left hemisphere 155.3
2828 Female, age 72, unknown 116.4
2666 Male, age 74, left hemisphere 98.7
1827 Male, age 72, unknown 96.8
1833 Male, age 53, unknown 92.1
1870 Female, age 42, unknown 91.4
2219 Male, age 76, both hemispheres 85.1
2411 Female, age 72, unknown 84.4
1830 Male, age 51, unknown 81.9
2019 Male, age 18, unknown 81.2
Dorsal raphe nucleus
nTPM: 91.6
2047 Male, age 72, unknown 98.4
2016 Female, age 72, unknown 96.2
1828 Male, age 53, unknown 92.0
2750 Male, age 76, both hemispheres 87.3
2298 Female, age 72, unknown 84.4
Inferior colliculus
nTPM: 91.1
2849 Male, age 72, unknown 105.4
1848 Female, age 42, unknown 88.7
1890 Male, age 53, unknown 87.6
2097 Female, age 72, unknown 82.6
Median raphe nucleus
nTPM: 90.5
2220 Male, age 76, midline 90.5
Pedunculopontine tegmental nucleus
nTPM: 81.8
1921 Female, age 85, both hemispheres 85.7
2334 Male, age 80, both hemispheres 83.3
2338 Male, age 61, both hemispheres 76.4
Periaquaductal grey, anterior
nTPM: 103.6
1795 Male, age 51, unknown 112.9
1947 Male, age 18, unknown 101.1
2502 Female, age 75, unknown 97.0
Periaquaductal grey, dorsal
nTPM: 95.4
2850 Male, age 76, both hemispheres 102.0
1840 Male, age 53, unknown 98.5
1831 Male, age 72, unknown 91.5
2464 Female, age 72, unknown 89.5
Periaquaductal grey, lateral
nTPM: 94.6
2140 Male, age 76, both hemispheres 103.2
2053 Male, age 18, unknown 92.6
2272 Male, age 74, both hemispheres 88.2
Pretectal area
nTPM: 94.8
1816 Male, age 51, unknown 105.6
2825 Male, age 18, unknown 101.0
2407 Male, age 75, both hemispheres 100.9
1944 Female, age 72, unknown 99.8
1817 Female, age 42, unknown 95.2
2007 Male, age 72, unknown 94.7
2667 Female, age 75, unknown 91.9
1815 Male, age 53, unknown 91.2
2316 Male, age 76, right hemisphere 89.8
2224 Female, age 72, unknown 88.1
2273 Male, age 74, both hemispheres 84.8
Red nucleus
nTPM: 86.9
2584 Male, age 75, left hemisphere 106.1
2588 Male, age 74, left hemisphere 96.2
2769 Male, age 72, unknown 93.3
2227 Male, age 72, unknown 92.4
2725 Female, age 75, unknown 89.4
2503 Female, age 72, unknown 87.0
2823 Male, age 76, right hemisphere 84.2
2785 Male, age 18, unknown 83.4
1954 Female, age 42, unknown 79.3
1904 Male, age 53, unknown 79.0
1821 Female, age 72, unknown 76.5
1865 Male, age 51, unknown 76.2
Substantia nigra
nTPM: 93.2
2665 Male, age 74, both hemispheres 111.2
2583 Male, age 75, right hemisphere 108.5
1916 Female, age 42, unknown 102.2
2699 Male, age 18, unknown 99.1
1851 Male, age 51, unknown 97.7
2590 Female, age 75, unknown 97.5
1941 Male, age 53, unknown 91.4
1889 Female, age 72, unknown 86.5
2241 Male, age 72, unknown 70.8
2409 Female, age 72, unknown 67.5
Superior colliculus
nTPM: 99.0
2664 Male, age 75, both hemispheres 145.4
1796 Male, age 53, unknown 109.2
2261 Male, age 18, unknown 107.6
2668 Female, age 75, unknown 95.5
1839 Male, age 51, unknown 95.3
2087 Female, age 72, unknown 91.8
1995 Male, age 72, unknown 90.6
2587 Male, age 74, left hemisphere 88.1
1913 Female, age 42, unknown 85.8
1895 Male, age 76, right hemisphere 80.4
Ventral tegmental area
nTPM: 94.3
2223 Female, age 72, unknown 107.1
1942 Male, age 51, unknown 99.1
2021 Male, age 53, unknown 98.0
1915 Female, age 42, unknown 97.1
2218 Male, age 76, both hemispheres 89.8
2410 Female, age 72, unknown 74.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 119.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 119.6
Samples: 139

Max nTPM: 291.4
Min nTPM: 46.1
Std nTPM: 40.4
Median nTPM: 111.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 291.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 281.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 213.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 206.2
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 206.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 196.2
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 186.2
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 184.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 177.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 174.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 174.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 174.2
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 174.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 172.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 172.5
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 171.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 169.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 169.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 169.1
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 165.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 165.0
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 163.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 160.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 160.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 155.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 154.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 151.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 150.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 147.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 147.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 147.1
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 146.8
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 144.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 144.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 143.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 140.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 139.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 136.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 134.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 134.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 133.2
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 133.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 131.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 130.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 128.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 128.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 128.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 127.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 127.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 127.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 126.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 125.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 124.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 124.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 123.3
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 123.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 121.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 121.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 119.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 119.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 119.3
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 119.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 116.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 116.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 116.4
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 116.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 113.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 113.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 112.7
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 111.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 111.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 111.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 111.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 108.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 108.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 108.1
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 107.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 107.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 107.2
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 106.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 106.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 105.1
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 105.0
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 104.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 104.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 104.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 102.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 102.0
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 100.6
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 99.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 98.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 97.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 97.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 96.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 96.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 96.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 95.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 94.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 94.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 94.5
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 94.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 94.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 91.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 91.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 90.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 90.4
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 90.3
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 90.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 89.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 89.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 87.2
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 86.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 83.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 83.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 83.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 83.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 81.8
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 81.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 81.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 81.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 81.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 80.9
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 79.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 78.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 75.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 74.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 74.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 72.9
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 72.8
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 72.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 72.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 69.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 69.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 66.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 65.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 60.1
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 54.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 47.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 46.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 45.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 45.9
FF:10158-103A5 76 years, female 45.9

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 38.5
Pig sample Sample description nTPM
Midbrain
nTPM: 38.5
Samples: 4

Max nTPM: 45.2
Min nTPM: 31.0
Sample A Female 41.0
Sample B Female 31.0
Sample C Male 36.6
Sample D Male 45.2
Periaqueductal gray
nTPM: 27.4
Samples: 3

Max nTPM: 33.4
Min nTPM: 22.7
Sample B Female 26.0
Sample C Male 33.4
Sample D Male 22.7
Substantia nigra
nTPM: 36.6
Samples: 4

Max nTPM: 44.5
Min nTPM: 28.8
Sample A Female 43.2
Sample B Female 29.9
Sample C Male 44.5
Sample D Male 28.8
Superior colliculi
nTPM: 35.8
Samples: 4

Max nTPM: 44.5
Min nTPM: 30.9
Sample A Female 44.5
Sample B Female 31.6
Sample C Male 30.9
Sample D Male 36.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 34.4
Mouse sample Sample description nTPM
Midbrain
nTPM: 34.4
Samples: 4

Max nTPM: 41.2
Min nTPM: 29.7
Sample A Male 41.2
Sample B Male 30.9
Sample C Female 29.7
Sample D Female 35.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 5.9
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 5.9
69059956 Antisense, RP_050317_04_G04, Mouse strain C57BL/6J (56 days, male) 5.9

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