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XBP1
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  • XBP1
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

XBP1
Synonyms XBP2
Gene descriptioni

Full gene name according to HGNC.

X-box binding protein 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 22
Cytoband q12.1
Chromosome location (bp) 28794555 - 28800597
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000100219 (version 103.38)
Entrez gene 7494
HGNC HGNC:12801
UniProt P17861 (UniProt - Evidence at protein level)
neXtProt NX_P17861
Antibodypedia XBP1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 164

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
XBP1-201
XBP1-202
XBP1-203
XBP1-204
XBP1-207


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
XBP1-201
ENSP00000216037
ENST00000216037
P17861 [Direct mapping]
X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
A0A024R1F0 [Target identity:100%; Query identity:100%]
X-box binding protein 1, isoform CRA_b
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription by RNA polymerase II]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0006986 [response to unfolded protein]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0007275 [multicellular organism development]
GO:0007517 [muscle organ development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0010832 [negative regulation of myotube differentiation]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030335 [positive regulation of cell migration]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031490 [chromatin DNA binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031648 [protein destabilization]
GO:0031670 [cellular response to nutrient]
GO:0032008 [positive regulation of TOR signaling]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0034599 [cellular response to oxidative stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035470 [positive regulation of vascular wound healing]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042307 [positive regulation of protein import into nucleus]
GO:0042632 [cholesterol homeostasis]
GO:0043066 [negative regulation of apoptotic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048666 [neuron development]
GO:0055089 [fatty acid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060612 [adipose tissue development]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071332 [cellular response to fructose stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1900100 [positive regulation of plasma cell differentiation]
GO:1900102 [negative regulation of endoplasmic reticulum unfolded protein response]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903489 [positive regulation of lactation]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000347 [positive regulation of hepatocyte proliferation]
Show all
261 aa
28.7 kDa
No 0
XBP1-202
ENSP00000343155
ENST00000344347
P17861 [Direct mapping]
X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001558 [regulation of cell growth]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription by RNA polymerase II]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0006986 [response to unfolded protein]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organism development]
GO:0007517 [muscle organ development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0010508 [positive regulation of autophagy]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031062 [positive regulation of histone methylation]
GO:0031490 [chromatin DNA binding]
GO:0031648 [protein destabilization]
GO:0031670 [cellular response to nutrient]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035470 [positive regulation of vascular wound healing]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048666 [neuron development]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055089 [fatty acid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation]
GO:0060612 [adipose tissue development]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071073 [positive regulation of phospholipid biosynthetic process]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071332 [cellular response to fructose stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1900100 [positive regulation of plasma cell differentiation]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901985 [positive regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903489 [positive regulation of lactation]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1904754 [positive regulation of vascular associated smooth muscle cell migration]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
Show all
376 aa
40.1 kDa
No 0
XBP1-203
ENSP00000385162
ENST00000403532
B1AHH2 [Direct mapping]
X-box-binding protein 1
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
266 aa
29.3 kDa
No 0
XBP1-204
ENSP00000384295
ENST00000405219
B1AHH1 [Direct mapping]
X-box-binding protein 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [DNA-binding transcription factor activity]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
211 aa
24 kDa
No 1
XBP1-207
ENSP00000481170
ENST00000611155
P17861 [Direct mapping]
X-box-binding protein 1 X-box-binding protein 1, cytoplasmic form X-box-binding protein 1, luminal form
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001525 [angiogenesis]
GO:0001558 [regulation of cell growth]
GO:0001889 [liver development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002639 [positive regulation of immunoglobulin production]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription by RNA polymerase II]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0006986 [response to unfolded protein]
GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response]
GO:0006996 [organelle organization]
GO:0007275 [multicellular organism development]
GO:0007517 [muscle organ development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0010508 [positive regulation of autophagy]
GO:0010832 [negative regulation of myotube differentiation]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030331 [estrogen receptor binding]
GO:0030335 [positive regulation of cell migration]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031062 [positive regulation of histone methylation]
GO:0031490 [chromatin DNA binding]
GO:0031648 [protein destabilization]
GO:0031670 [cellular response to nutrient]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032869 [cellular response to insulin stimulus]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035356 [cellular triglyceride homeostasis]
GO:0035470 [positive regulation of vascular wound healing]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042149 [cellular response to glucose starvation]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045348 [positive regulation of MHC class II biosynthetic process]
GO:0045579 [positive regulation of B cell differentiation]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048666 [neuron development]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055089 [fatty acid homeostasis]
GO:0055092 [sterol homeostasis]
GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation]
GO:0060612 [adipose tissue development]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0071073 [positive regulation of phospholipid biosynthetic process]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071332 [cellular response to fructose stimulus]
GO:0071333 [cellular response to glucose stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071498 [cellular response to fluid shear stress]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:1900100 [positive regulation of plasma cell differentiation]
GO:1900103 [positive regulation of endoplasmic reticulum unfolded protein response]
GO:1901985 [positive regulation of protein acetylation]
GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903489 [positive regulation of lactation]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1904754 [positive regulation of vascular associated smooth muscle cell migration]
GO:1990418 [response to insulin-like growth factor stimulus]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000347 [positive regulation of hepatocyte proliferation]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
Show all
376 aa
40.1 kDa
No 0

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