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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:182.2 nTPM
HPA:182.2 nTPM
GTEx:85.7 nTPM
FANTOM5:509.4 Scaled Tags Per Million
Pig:27.0 nTPM
Mouse:24.6 nTPM
Allen mouse:0.8 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 182.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 140.8
2411 Female, age 72, unknown 171.7
1830 Male, age 51, unknown 170.7
2019 Male, age 18, unknown 165.3
1833 Male, age 53, unknown 156.6
1870 Female, age 42, unknown 155.6
2828 Female, age 72, unknown 145.1
2586 Male, age 75, left hemisphere 119.4
2666 Male, age 74, left hemisphere 117.4
1827 Male, age 72, unknown 103.7
2219 Male, age 76, both hemispheres 102.1
Dorsal raphe nucleus
nTPM: 110.9
2750 Male, age 76, both hemispheres 175.7
2016 Female, age 72, unknown 115.4
1828 Male, age 53, unknown 104.1
2047 Male, age 72, unknown 83.1
2298 Female, age 72, unknown 76.3
Inferior colliculus
nTPM: 95.5
1848 Female, age 42, unknown 100.4
2849 Male, age 72, unknown 96.4
1890 Male, age 53, unknown 94.8
2097 Female, age 72, unknown 90.3
Median raphe nucleus
nTPM: 73.7
2220 Male, age 76, midline 73.7
Pedunculopontine tegmental nucleus
nTPM: 114.0
2334 Male, age 80, both hemispheres 135.9
1921 Female, age 85, both hemispheres 108.2
2338 Male, age 61, both hemispheres 98.1
Periaquaductal grey, anterior
nTPM: 106.2
2502 Female, age 75, unknown 117.9
1947 Male, age 18, unknown 111.0
1795 Male, age 51, unknown 89.8
Periaquaductal grey, dorsal
nTPM: 77.2
2464 Female, age 72, unknown 119.0
1831 Male, age 72, unknown 72.7
2850 Male, age 76, both hemispheres 63.5
1840 Male, age 53, unknown 53.5
Periaquaductal grey, lateral
nTPM: 97.2
2272 Male, age 74, both hemispheres 116.5
2053 Male, age 18, unknown 90.9
2140 Male, age 76, both hemispheres 84.2
Pretectal area
nTPM: 107.4
2316 Male, age 76, right hemisphere 165.4
2667 Female, age 75, unknown 125.8
1815 Male, age 53, unknown 123.6
2407 Male, age 75, both hemispheres 120.5
1817 Female, age 42, unknown 107.7
2007 Male, age 72, unknown 107.7
2825 Male, age 18, unknown 102.1
2273 Male, age 74, both hemispheres 98.3
2224 Female, age 72, unknown 87.1
1944 Female, age 72, unknown 71.9
1816 Male, age 51, unknown 71.5
Red nucleus
nTPM: 182.2
2227 Male, age 72, unknown 209.8
1904 Male, age 53, unknown 209.5
2769 Male, age 72, unknown 209.4
2785 Male, age 18, unknown 206.4
1865 Male, age 51, unknown 200.7
2503 Female, age 72, unknown 195.3
2823 Male, age 76, right hemisphere 185.8
1821 Female, age 72, unknown 179.7
1954 Female, age 42, unknown 163.1
2588 Male, age 74, left hemisphere 162.2
2725 Female, age 75, unknown 132.6
2584 Male, age 75, left hemisphere 132.0
Substantia nigra
nTPM: 105.4
1851 Male, age 51, unknown 125.1
2590 Female, age 75, unknown 121.7
2583 Male, age 75, right hemisphere 121.5
2409 Female, age 72, unknown 117.1
1941 Male, age 53, unknown 107.0
1889 Female, age 72, unknown 106.3
2699 Male, age 18, unknown 101.1
2241 Male, age 72, unknown 86.3
1916 Female, age 42, unknown 84.0
2665 Male, age 74, both hemispheres 83.5
Superior colliculus
nTPM: 123.8
1995 Male, age 72, unknown 176.4
1913 Female, age 42, unknown 174.8
1895 Male, age 76, right hemisphere 147.7
1839 Male, age 51, unknown 134.3
2587 Male, age 74, left hemisphere 126.1
1796 Male, age 53, unknown 110.6
2668 Female, age 75, unknown 102.7
2261 Male, age 18, unknown 92.7
2664 Male, age 75, both hemispheres 87.6
2087 Female, age 72, unknown 84.8
Ventral tegmental area
nTPM: 117.3
2410 Female, age 72, unknown 155.8
2223 Female, age 72, unknown 125.5
2021 Male, age 53, unknown 110.8
1915 Female, age 42, unknown 110.2
1942 Male, age 51, unknown 107.8
2218 Male, age 76, both hemispheres 93.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 85.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 85.7
Samples: 139

Max nTPM: 370.4
Min nTPM: 35.8
Std nTPM: 45.2
Median nTPM: 73.3
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 370.4
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 242.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 207.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 192.9
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 184.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 179.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 173.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 173.1
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 171.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 160.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 153.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 150.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 145.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 142.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 140.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 130.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 130.3
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 129.7
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 125.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 125.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 124.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 124.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 123.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 121.5
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 117.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 115.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 114.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 107.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 103.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 100.6
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 100.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 100.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 99.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 98.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 97.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 97.0
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 94.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 93.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 93.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 92.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 92.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 92.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 92.0
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 90.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 90.0
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 89.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 88.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 87.5
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 87.1
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 87.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 86.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 84.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 83.3
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 82.4
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 80.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 80.3
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 80.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 79.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 79.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 79.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 78.2
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 78.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 78.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 77.6
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 77.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 77.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 74.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 74.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 73.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 73.3
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 73.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 72.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 72.0
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 70.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 69.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 69.1
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 68.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 68.0
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 67.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 66.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 65.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 65.7
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 64.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 64.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 64.3
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 64.0
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 63.7
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 63.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 63.3
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 63.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 63.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 62.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 62.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 61.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 61.5
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 61.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 60.3
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 60.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 60.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 59.5
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 58.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 57.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 57.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 57.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 56.8
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 56.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 56.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 55.9
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 55.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 55.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 54.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 53.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 53.8
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 52.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 52.8
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 52.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 51.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 51.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 50.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 50.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 50.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 49.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 48.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 48.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 48.0
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 48.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 47.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 47.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 47.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 45.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 45.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 44.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 41.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 41.4
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 38.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 37.4
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 36.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 35.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 35.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 509.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 509.4
FF:10158-103A5 76 years, female 509.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 27.0
Pig sample Sample description nTPM
Midbrain
nTPM: 22.1
Samples: 4

Max nTPM: 32.5
Min nTPM: 16.6
Sample A Female 32.5
Sample B Female 21.9
Sample C Male 17.2
Sample D Male 16.6
Periaqueductal gray
nTPM: 19.7
Samples: 3

Max nTPM: 20.7
Min nTPM: 17.9
Sample B Female 20.5
Sample C Male 20.7
Sample D Male 17.9
Substantia nigra
nTPM: 27.0
Samples: 4

Max nTPM: 32.1
Min nTPM: 20.6
Sample A Female 24.5
Sample B Female 32.1
Sample C Male 20.6
Sample D Male 30.7
Superior colliculi
nTPM: 24.5
Samples: 4

Max nTPM: 29.8
Min nTPM: 19.5
Sample A Female 26.5
Sample B Female 29.8
Sample C Male 19.5
Sample D Male 22.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 24.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 24.7
Samples: 4

Max nTPM: 26.1
Min nTPM: 23.6
Sample A Male 26.1
Sample B Male 23.6
Sample C Female 25.0
Sample D Female 23.9

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.8
69527860 Antisense, RP_050421_02_F04, Mouse strain C57BL/6J (56 days, male) 1.2
74658032 Antisense, RP_060220_04_C05, Mouse strain C57BL/6J (56 days, male) 0.4

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