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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q13.2
Chromosome location (bp)
41092592 - 41180077
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
EP300-201
EP300-203
EP300-212
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000123 [histone acetyltransferase complex] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0001666 [response to hypoxia] GO:0001756 [somitogenesis] GO:0001966 [thigmotaxis] GO:0002039 [p53 binding] GO:0002209 [behavioral defense response] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003684 [damaged DNA binding] GO:0003712 [transcription coregulator activity] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0004468 [lysine N-acetyltransferase activity, acting on acetyl phosphate as donor] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006110 [regulation of glycolytic process] GO:0006283 [transcription-coupled nucleotide-excision repair] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006473 [protein acetylation] GO:0006475 [internal protein amino acid acetylation] GO:0006915 [apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006990 [positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response] GO:0007049 [cell cycle] GO:0007219 [Notch signaling pathway] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0007399 [nervous system development] GO:0007507 [heart development] GO:0007519 [skeletal muscle tissue development] GO:0007611 [learning or memory] GO:0007623 [circadian rhythm] GO:0008013 [beta-catenin binding] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0009887 [animal organ morphogenesis] GO:0010506 [regulation of autophagy] GO:0010628 [positive regulation of gene expression] GO:0010742 [macrophage derived foam cell differentiation] GO:0010821 [regulation of mitochondrion organization] GO:0010976 [positive regulation of neuron projection development] GO:0016032 [viral process] GO:0016407 [acetyltransferase activity] GO:0016573 [histone acetylation] GO:0016579 [protein deubiquitination] GO:0016740 [transferase activity] GO:0016746 [transferase activity, transferring acyl groups] GO:0018076 [N-terminal peptidyl-lysine acetylation] GO:0018215 [protein phosphopantetheinylation] GO:0018393 [internal peptidyl-lysine acetylation] GO:0018394 [peptidyl-lysine acetylation] GO:0030183 [B cell differentiation] GO:0030220 [platelet formation] GO:0030324 [lung development] GO:0030511 [positive regulation of transforming growth factor beta receptor signaling pathway] GO:0031333 [negative regulation of protein-containing complex assembly] GO:0031490 [chromatin DNA binding] GO:0031648 [protein destabilization] GO:0032092 [positive regulation of protein binding] GO:0032481 [positive regulation of type I interferon production] GO:0032991 [protein-containing complex] GO:0032993 [protein-DNA complex] GO:0033613 [activating transcription factor binding] GO:0034644 [cellular response to UV] GO:0035257 [nuclear hormone receptor binding] GO:0035264 [multicellular organism growth] GO:0035855 [megakaryocyte development] GO:0036268 [swimming] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043627 [response to estrogen] GO:0043923 [positive regulation by host of viral transcription] GO:0043967 [histone H4 acetylation] GO:0043969 [histone H2B acetylation] GO:0045444 [fat cell differentiation] GO:0045652 [regulation of megakaryocyte differentiation] GO:0045721 [negative regulation of gluconeogenesis] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045815 [positive regulation of gene expression, epigenetic] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046872 [metal ion binding] GO:0048156 [tau protein binding] GO:0048511 [rhythmic process] GO:0050681 [androgen receptor binding] GO:0050821 [protein stabilization] GO:0051059 [NF-kappaB binding] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051726 [regulation of cell cycle] GO:0060325 [face morphogenesis] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061733 [peptide-lysine-N-acetyltransferase activity] GO:0061920 [protein propionyltransferase activity] GO:0061921 [peptidyl-lysine propionylation] GO:0090043 [regulation of tubulin deacetylation] GO:0097157 [pre-mRNA intronic binding] GO:0097677 [STAT family protein binding] GO:0140065 [peptide butyryltransferase activity] GO:0140066 [peptidyl-lysine crotonylation] GO:0140067 [peptidyl-lysine butyrylation] GO:0140068 [histone crotonyltransferase activity] GO:0140069 [histone butyryltransferase activity] GO:1900034 [regulation of cellular response to heat] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904837 [beta-catenin-TCF complex assembly] GO:1905636 [positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Congenital malformations Other congenital malformations Protein evidence (Ezkurdia et al 2014)