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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Human disease related genes Metabolic proteins Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
14
Cytoband
q23.2
Chromosome location (bp)
61695513 - 61748259
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HIF1A-201
HIF1A-202
HIF1A-203
HIF1A-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species] GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001666 [response to hypoxia] GO:0001837 [epithelial to mesenchymal transition] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002039 [p53 binding] GO:0002248 [connective tissue replacement involved in inflammatory response wound healing] GO:0002534 [cytokine production involved in inflammatory response] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006110 [regulation of glycolytic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007165 [signal transduction] GO:0008134 [transcription factor binding] GO:0010039 [response to iron ion] GO:0010468 [regulation of gene expression] GO:0010573 [vascular endothelial growth factor production] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010634 [positive regulation of epithelial cell migration] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016607 [nuclear speck] GO:0019221 [cytokine-mediated signaling pathway] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031625 [ubiquitin protein ligase binding] GO:0032364 [oxygen homeostasis] GO:0032722 [positive regulation of chemokine production] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032963 [collagen metabolic process] GO:0032991 [protein-containing complex] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043565 [sequence-specific DNA binding] GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress] GO:0043687 [post-translational protein modification] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045821 [positive regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046886 [positive regulation of hormone biosynthetic process] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051541 [elastin metabolic process] GO:0051879 [Hsp90 protein binding] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070101 [positive regulation of chemokine-mediated signaling pathway] GO:0071347 [cellular response to interleukin-1] GO:0071456 [cellular response to hypoxia] GO:0090575 [RNA polymerase II transcription regulator complex] GO:0098586 [cellular response to virus] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1904115 [axon cytoplasm] GO:2000273 [positive regulation of signaling receptor activity] GO:2000434 [regulation of protein neddylation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species] GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001666 [response to hypoxia] GO:0001837 [epithelial to mesenchymal transition] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002039 [p53 binding] GO:0002248 [connective tissue replacement involved in inflammatory response wound healing] GO:0002534 [cytokine production involved in inflammatory response] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006110 [regulation of glycolytic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007165 [signal transduction] GO:0008134 [transcription factor binding] GO:0010039 [response to iron ion] GO:0010468 [regulation of gene expression] GO:0010573 [vascular endothelial growth factor production] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010634 [positive regulation of epithelial cell migration] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016607 [nuclear speck] GO:0019221 [cytokine-mediated signaling pathway] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031625 [ubiquitin protein ligase binding] GO:0032364 [oxygen homeostasis] GO:0032722 [positive regulation of chemokine production] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032963 [collagen metabolic process] GO:0032991 [protein-containing complex] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043565 [sequence-specific DNA binding] GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress] GO:0043687 [post-translational protein modification] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045821 [positive regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046886 [positive regulation of hormone biosynthetic process] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051541 [elastin metabolic process] GO:0051879 [Hsp90 protein binding] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070101 [positive regulation of chemokine-mediated signaling pathway] GO:0071347 [cellular response to interleukin-1] GO:0071456 [cellular response to hypoxia] GO:0090575 [RNA polymerase II transcription regulator complex] GO:0098586 [cellular response to virus] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1904115 [axon cytoplasm] GO:2000273 [positive regulation of signaling receptor activity] GO:2000434 [regulation of protein neddylation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Human disease related genes Cancers Head and neck cancers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302 [response to reactive oxygen species] GO:0000785 [chromatin] GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001525 [angiogenesis] GO:0001568 [blood vessel development] GO:0001666 [response to hypoxia] GO:0001755 [neural crest cell migration] GO:0001837 [epithelial to mesenchymal transition] GO:0001892 [embryonic placenta development] GO:0001922 [B-1 B cell homeostasis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001944 [vasculature development] GO:0001947 [heart looping] GO:0002039 [p53 binding] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002248 [connective tissue replacement involved in inflammatory response wound healing] GO:0002534 [cytokine production involved in inflammatory response] GO:0003151 [outflow tract morphogenesis] GO:0003208 [cardiac ventricle morphogenesis] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription regulator complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006089 [lactate metabolic process] GO:0006110 [regulation of glycolytic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006879 [cellular iron ion homeostasis] GO:0007165 [signal transduction] GO:0007595 [lactation] GO:0008134 [transcription factor binding] GO:0008542 [visual learning] GO:0010039 [response to iron ion] GO:0010468 [regulation of gene expression] GO:0010508 [positive regulation of autophagy] GO:0010573 [vascular endothelial growth factor production] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010634 [positive regulation of epithelial cell migration] GO:0014850 [response to muscle activity] GO:0016239 [positive regulation of macroautophagy] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016607 [nuclear speck] GO:0019221 [cytokine-mediated signaling pathway] GO:0019896 [axonal transport of mitochondrion] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0021502 [neural fold elevation formation] GO:0021987 [cerebral cortex development] GO:0030154 [cell differentiation] GO:0030279 [negative regulation of ossification] GO:0030502 [negative regulation of bone mineralization] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031514 [motile cilium] GO:0031625 [ubiquitin protein ligase binding] GO:0032007 [negative regulation of TOR signaling] GO:0032364 [oxygen homeostasis] GO:0032722 [positive regulation of chemokine production] GO:0032909 [regulation of transforming growth factor beta2 production] GO:0032963 [collagen metabolic process] GO:0032991 [protein-containing complex] GO:0035035 [histone acetyltransferase binding] GO:0035162 [embryonic hemopoiesis] GO:0035257 [nuclear hormone receptor binding] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042127 [regulation of cell population proliferation] GO:0042541 [hemoglobin biosynthetic process] GO:0042593 [glucose homeostasis] GO:0042826 [histone deacetylase binding] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0043565 [sequence-specific DNA binding] GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress] GO:0043687 [post-translational protein modification] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045766 [positive regulation of angiogenesis] GO:0045821 [positive regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045926 [negative regulation of growth] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046716 [muscle cell cellular homeostasis] GO:0046886 [positive regulation of hormone biosynthetic process] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048514 [blood vessel morphogenesis] GO:0048546 [digestive tract morphogenesis] GO:0048593 [camera-type eye morphogenesis] GO:0050790 [regulation of catalytic activity] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051216 [cartilage development] GO:0051541 [elastin metabolic process] GO:0051879 [Hsp90 protein binding] GO:0060574 [intestinal epithelial cell maturation] GO:0061030 [epithelial cell differentiation involved in mammary gland alveolus development] GO:0061072 [iris morphogenesis] GO:0061298 [retina vasculature development in camera-type eye] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070101 [positive regulation of chemokine-mediated signaling pathway] GO:0070243 [regulation of thymocyte apoptotic process] GO:0070244 [negative regulation of thymocyte apoptotic process] GO:0070888 [E-box binding] GO:0071347 [cellular response to interleukin-1] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0090575 [RNA polymerase II transcription regulator complex] GO:0097411 [hypoxia-inducible factor-1alpha signaling pathway] GO:0098586 [cellular response to virus] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903599 [positive regulation of autophagy of mitochondrion] GO:1903715 [regulation of aerobic respiration] GO:1904115 [axon cytoplasm] GO:2000273 [positive regulation of signaling receptor activity] GO:2000378 [negative regulation of reactive oxygen species metabolic process] GO:2000434 [regulation of protein neddylation] GO:2001054 [negative regulation of mesenchymal cell apoptotic process]
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