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BMP7
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  • BMP7
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

BMP7
Synonyms OP-1
Gene descriptioni

Full gene name according to HGNC.

Bone morphogenetic protein 7
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 20
Cytoband q13.31
Chromosome location (bp) 57168753 - 57266641
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000101144 (version 103.38)
Entrez gene 655
HGNC HGNC:1074
UniProt P18075 (UniProt - Evidence at protein level)
neXtProt NX_P18075
Antibodypedia BMP7 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 247

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BMP7-201
BMP7-202
BMP7-203
BMP7-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
BMP7-201
ENSP00000379204
ENST00000395863
P18075 [Direct mapping]
Bone morphogenetic protein 7
A8K571 [Target identity:100%; Query identity:100%]
Bone morphogenetic protein 7 (Osteogenic protein 1), isoform CRA_b; cDNA FLJ78019, highly similar to Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1), mRNA; cDNA, FLJ92758, Homo sapiens bone morphogenetic protein 7 (osteogenic protein 1)(BMP7), mRNA
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001654 [eye development]
GO:0001656 [metanephros development]
GO:0001657 [ureteric bud development]
GO:0001707 [mesoderm formation]
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0003272 [endocardial cushion formation]
GO:0003344 [pericardium morphogenesis]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007275 [multicellular organism development]
GO:0007389 [pattern specification process]
GO:0007411 [axon guidance]
GO:0007435 [salivary gland morphogenesis]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009880 [embryonic pattern specification]
GO:0009887 [animal organ morphogenesis]
GO:0010628 [positive regulation of gene expression]
GO:0010664 [negative regulation of striated muscle cell apoptotic process]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0010942 [positive regulation of cell death]
GO:0016358 [dendrite development]
GO:0021502 [neural fold elevation formation]
GO:0030154 [cell differentiation]
GO:0030326 [embryonic limb morphogenesis]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030855 [epithelial cell differentiation]
GO:0030902 [hindbrain development]
GO:0031982 [vesicle]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032355 [response to estradiol]
GO:0033280 [response to vitamin D]
GO:0034116 [positive regulation of heterotypic cell-cell adhesion]
GO:0034504 [protein localization to nucleus]
GO:0035239 [tube morphogenesis]
GO:0042325 [regulation of phosphorylation]
GO:0042326 [negative regulation of phosphorylation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043434 [response to peptide hormone]
GO:0045597 [positive regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0045786 [negative regulation of cell cycle]
GO:0045839 [negative regulation of mitotic nuclear division]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048468 [cell development]
GO:0048593 [camera-type eye morphogenesis]
GO:0048596 [embryonic camera-type eye morphogenesis]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048738 [cardiac muscle tissue development]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0048762 [mesenchymal cell differentiation]
GO:0048812 [neuron projection morphogenesis]
GO:0050768 [negative regulation of neurogenesis]
GO:0051216 [cartilage development]
GO:0060037 [pharyngeal system development]
GO:0060272 [embryonic skeletal joint morphogenesis]
GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060411 [cardiac septum morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060485 [mesenchyme development]
GO:0060548 [negative regulation of cell death]
GO:0060686 [negative regulation of prostatic bud formation]
GO:0060687 [regulation of branching involved in prostate gland morphogenesis]
GO:0060710 [chorio-allantoic fusion]
GO:0061384 [heart trabecula morphogenesis]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070487 [monocyte aggregation]
GO:0070700 [BMP receptor binding]
GO:0071456 [cellular response to hypoxia]
GO:0071773 [cellular response to BMP stimulus]
GO:0072040 [negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis]
GO:0072125 [negative regulation of glomerular mesangial cell proliferation]
GO:0072133 [metanephric mesenchyme morphogenesis]
GO:0072134 [nephrogenic mesenchyme morphogenesis]
GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development]
GO:0090336 [positive regulation of brown fat cell differentiation]
GO:1900006 [positive regulation of dendrite development]
GO:1900106 [positive regulation of hyaluranon cable assembly]
GO:1901223 [negative regulation of NIK/NF-kappaB signaling]
GO:1905069 [allantois development]
GO:1905312 [positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis]
GO:2000121 [regulation of removal of superoxide radicals]
Show all
431 aa
49.3 kDa
Yes 0
BMP7-202
ENSP00000379205
ENST00000395864
B1AKZ9 [Direct mapping]
Bone morphogenetic protein 7
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
Show all
365 aa
42 kDa
Yes 0
BMP7-203
ENSP00000390814
ENST00000433911
H0Y4B5 [Direct mapping]
Bone morphogenetic protein 7
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
Show all
297 aa
34.2 kDa
No 0
BMP7-204
ENSP00000398687
ENST00000450594
B1AL00 [Direct mapping]
Bone morphogenetic protein 7
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
Show all
412 aa
46.7 kDa
Yes 0

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The Human Protein Atlas

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.