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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:601.6 nTPM
HPA:601.6 nTPM
GTEx:171.8 nTPM
FANTOM5:321.0 Scaled Tags Per Million
Pig:85.7 nTPM
Mouse:74.5 nTPM
Allen mouse:10.3 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 601.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 601.6
2586 Male, age 75, left hemisphere 1206.0
2411 Female, age 72, unknown 717.0
2219 Male, age 76, both hemispheres 584.4
1870 Female, age 42, unknown 575.9
2666 Male, age 74, left hemisphere 575.8
2019 Male, age 18, unknown 553.0
1833 Male, age 53, unknown 517.7
1830 Male, age 51, unknown 481.1
2828 Female, age 72, unknown 464.6
1827 Male, age 72, unknown 340.7
Dorsal raphe nucleus
nTPM: 487.9
2750 Male, age 76, both hemispheres 722.7
2298 Female, age 72, unknown 445.8
2047 Male, age 72, unknown 442.1
2016 Female, age 72, unknown 416.5
1828 Male, age 53, unknown 412.3
Inferior colliculus
nTPM: 477.9
1890 Male, age 53, unknown 605.6
2849 Male, age 72, unknown 559.7
2097 Female, age 72, unknown 373.8
1848 Female, age 42, unknown 372.4
Median raphe nucleus
nTPM: 551.2
2220 Male, age 76, midline 551.2
Pedunculopontine tegmental nucleus
nTPM: 454.1
2334 Male, age 80, both hemispheres 565.4
2338 Male, age 61, both hemispheres 497.7
1921 Female, age 85, both hemispheres 299.1
Periaquaductal grey, anterior
nTPM: 562.6
2502 Female, age 75, unknown 901.6
1795 Male, age 51, unknown 538.9
1947 Male, age 18, unknown 247.4
Periaquaductal grey, dorsal
nTPM: 466.6
2464 Female, age 72, unknown 712.5
2850 Male, age 76, both hemispheres 510.9
1840 Male, age 53, unknown 453.8
1831 Male, age 72, unknown 189.3
Periaquaductal grey, lateral
nTPM: 339.6
2140 Male, age 76, both hemispheres 435.1
2053 Male, age 18, unknown 378.4
2272 Male, age 74, both hemispheres 205.3
Pretectal area
nTPM: 377.7
2007 Male, age 72, unknown 639.6
2224 Female, age 72, unknown 519.0
2667 Female, age 75, unknown 395.0
1817 Female, age 42, unknown 386.8
2825 Male, age 18, unknown 381.4
1816 Male, age 51, unknown 375.0
1815 Male, age 53, unknown 365.0
2316 Male, age 76, right hemisphere 311.4
2407 Male, age 75, both hemispheres 287.4
1944 Female, age 72, unknown 251.9
2273 Male, age 74, both hemispheres 242.7
Red nucleus
nTPM: 600.5
2503 Female, age 72, unknown 995.1
2769 Male, age 72, unknown 854.5
2227 Male, age 72, unknown 822.8
2588 Male, age 74, left hemisphere 721.4
2785 Male, age 18, unknown 673.8
1865 Male, age 51, unknown 652.1
1904 Male, age 53, unknown 575.8
2584 Male, age 75, left hemisphere 535.0
1954 Female, age 42, unknown 515.1
2823 Male, age 76, right hemisphere 302.4
2725 Female, age 75, unknown 296.7
1821 Female, age 72, unknown 261.6
Substantia nigra
nTPM: 353.5
1851 Male, age 51, unknown 479.6
2583 Male, age 75, right hemisphere 476.9
2699 Male, age 18, unknown 441.0
2665 Male, age 74, both hemispheres 422.3
2590 Female, age 75, unknown 409.2
1889 Female, age 72, unknown 338.3
1916 Female, age 42, unknown 305.8
2409 Female, age 72, unknown 255.3
1941 Male, age 53, unknown 254.4
2241 Male, age 72, unknown 152.5
Superior colliculus
nTPM: 484.4
2587 Male, age 74, left hemisphere 702.4
1995 Male, age 72, unknown 620.3
2664 Male, age 75, both hemispheres 567.4
2261 Male, age 18, unknown 545.7
1796 Male, age 53, unknown 503.5
1913 Female, age 42, unknown 477.9
1839 Male, age 51, unknown 399.9
2668 Female, age 75, unknown 374.9
2087 Female, age 72, unknown 357.6
1895 Male, age 76, right hemisphere 294.3
Ventral tegmental area
nTPM: 518.2
2223 Female, age 72, unknown 784.8
2021 Male, age 53, unknown 587.4
2218 Male, age 76, both hemispheres 504.7
1915 Female, age 42, unknown 461.1
1942 Male, age 51, unknown 429.4
2410 Female, age 72, unknown 342.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 171.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 171.8
Samples: 139

Max nTPM: 747.7
Min nTPM: 46.6
Std nTPM: 106.0
Median nTPM: 137.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 747.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 542.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 471.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 452.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 445.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 434.7
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 391.1
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 373.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 373.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 361.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 339.2
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 321.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 314.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 310.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 303.7
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 300.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 282.1
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 270.1
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 269.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 266.6
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 262.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 250.4
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 249.6
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 238.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 229.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 228.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 225.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 225.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 222.6
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 220.9
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 212.5
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 212.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 208.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 203.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 201.5
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 201.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 200.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 199.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 198.8
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 195.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 194.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 191.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 190.7
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 190.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 188.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 187.2
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 184.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 180.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 178.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 176.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 175.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 175.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 174.2
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 171.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 168.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 168.1
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 168.0
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 167.4
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 162.1
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 159.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 158.8
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 153.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 151.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 150.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 145.0
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 141.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 140.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 139.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 138.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 137.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 137.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 135.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 135.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 132.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 131.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 129.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 129.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 126.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 125.8
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 125.0
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 124.2
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 124.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 123.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 122.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 121.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 121.4
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 121.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 120.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 117.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 116.9
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 116.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 113.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 113.1
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 112.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 109.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 109.5
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 109.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 109.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 108.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 108.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 105.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 104.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 104.3
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 103.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 101.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 100.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 98.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 97.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 97.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 96.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 96.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 95.4
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 94.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 92.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 91.9
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 91.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 90.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 89.3
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 86.7
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 84.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 84.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 84.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 83.7
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 80.9
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 77.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 76.5
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 75.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 73.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 73.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 73.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 73.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 73.4
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 68.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 67.4
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 65.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 61.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 57.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 55.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 46.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 321.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 321.0
FF:10158-103A5 76 years, female 321.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 85.7
Pig sample Sample description nTPM
Midbrain
nTPM: 73.7
Samples: 4

Max nTPM: 103.0
Min nTPM: 51.1
Sample A Female 103.0
Sample B Female 87.1
Sample C Male 51.1
Sample D Male 53.7
Periaqueductal gray
nTPM: 60.3
Samples: 3

Max nTPM: 71.3
Min nTPM: 52.0
Sample B Female 71.3
Sample C Male 52.0
Sample D Male 57.6
Substantia nigra
nTPM: 85.7
Samples: 4

Max nTPM: 121.3
Min nTPM: 59.1
Sample A Female 92.3
Sample B Female 59.1
Sample C Male 69.9
Sample D Male 121.3
Superior colliculi
nTPM: 68.1
Samples: 4

Max nTPM: 87.0
Min nTPM: 31.5
Sample A Female 87.0
Sample B Female 31.5
Sample C Male 72.6
Sample D Male 81.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 74.5
Mouse sample Sample description nTPM
Midbrain
nTPM: 74.6
Samples: 4

Max nTPM: 82.8
Min nTPM: 66.2
Sample A Male 82.8
Sample B Male 71.7
Sample C Female 66.2
Sample D Female 77.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 10.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 10.3
1881 Antisense, RP_040604_01_D07, Mouse strain C57BL/6J (56 days, male) 10.3
1880 Antisense, RP_040604_01_D07, Mouse strain C57BL/6J (56 days, male) 7.7

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