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MAN2B1
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                                • SUMMARY

                                • TISSUE

                                • BRAIN

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                                • MAN2B1
                                SINGLE CELL TYPE HEART MUSCLE Show tissue menu
                                ADIPOSE TISSUE BONE MARROW BRAIN BREAST BRONCHUS COLON ENDOMETRIUM ESOPHAGUS EYE HEART MUSCLE
                                KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PBMC PLACENTA PROSTATE RECTUM
                                SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS THYMUS TONGUE VASCULAR
                                Cell type proteome
                                Endothelial cells
                                Muscle cells
                                Mesenchymal cells
                                HEART MUSCLEi

                                RNA expression in the single cell type clusters identified in this tissue visualized by a UMAP plot (top) and a bar chart (bottom).

                                - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart below. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single Cell Type section and 2) cluster color, which assigns a unique color to each cluster. Thre are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,โ‰ฅ75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon


                                - The BAR CHART shows RNA expression (nTPM) in each cell type cluster. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single Cell Type section and 2) cluster color, which assigns a unique color to each cluster.

                                Read more
                                Cell type color
                                Cluster color
                                Colored according to cell type group
                                Colored according to clusters
                                Intensity
                                Interval
                                Hexagon
                                Scatter plot, all cells color scale - % of max
                                Scatter plot, all cells color scale - fixed intervals
                                Hexagon, average of all cells
                                2345678910111213141516UMAP-2024681012UMAPc-0c-1c-2c-3c-4c-5c-6c-7c-8
                                Cluster Cell type Expression (nTPM)
                                0 10
                                c-0 Cardiomyocytes
                                c-1 Cardiomyocytes
                                c-2 Cardiomyocytes
                                c-3 Smooth muscle cells
                                c-4 Endothelial cells
                                c-5 Cardiomyocytes
                                c-6 Endothelial cells
                                c-7 Fibroblasts
                                c-8 Cardiomyocytes


                                CELL TYPE MARKERSi

                                The heatmap in this section shows expression of the currently selected gene (on top) and well-known cell type markers in the different single cell type clusters of this tissue. The panel on the left shows which cell type each marker is associated with. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

                                Hover the mouse-pointer over the individual data points (squares) to see nTPM level and Z-score. Clicking on a gene name redirects to the corresponding gene page.
                                Z-score is when you normalize a variable such that the standard deviation is 1 and the mean is 0. Thus, all the genes are easier to compare, as they have the same center and distribution.

                                Read more
                                Max-norm
                                Z-score
                                Fraction of highest expression
                                log(nTPM) z-score
                                MAN2B1CD19CR2MS4A1GZMBIL3RACEBPEHDCMS4A2CD163CD68MARCOMRC1MSR1FCGR3AKIR2DL4PIM2CD3ECD4CD8AFOXP3IL17ACD34PECAM1SELESLC2A1VWFMBPMPZS100BSOX10COL3A1FBN1LUMMYH7MYL2MYL7TTNACTA2ACTG2CNN1MYH11Cardiomyocytes c-0Cardiomyocytes c-1Cardiomyocytes c-2Smooth muscle cells c-3Endothelial cells c-4Cardiomyocytes c-5Endothelial cells c-6Fibroblasts c-7Cardiomyocytes c-8Current geneB-cellsDendritic cellsGranulocytesMacrophagesMonocytesNK-cellsPlasma cellsT-cellsEndothelial cellsSchwann cellsFibroblastsCardiomyocytesSmooth muscle cells00.250.50.751-4-2024

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