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TGFB1
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  • TGFB1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

TGFB1
Synonyms CED, DPD1, TGFB, TGFbeta
Gene descriptioni

Full gene name according to HGNC.

Transforming growth factor beta 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Human disease related genes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Secreted
Protein evidence Evidence at transcript level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 19
Cytoband q13.2
Chromosome location (bp) 41301587 - 41353922
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000105329 (version 103.38)
Entrez gene 7040
HGNC HGNC:11766
UniProt
neXtProt
Antibodypedia TGFB1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more


PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
TGFB1-201
TGFB1-204
TGFB1-205


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
TGFB1-201
ENSP00000221930
ENST00000221930
A0A499FJK2 [Direct mapping]
Transforming growth factor beta
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Immune system diseases
   Allergies and autoimmune diseases
   Musculoskeletal diseases
   Skeletal diseases
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000902 [cell morphogenesis]
GO:0001570 [vasculogenesis]
GO:0001657 [ureteric bud development]
GO:0001666 [response to hypoxia]
GO:0001763 [morphogenesis of a branching structure]
GO:0001775 [cell activation]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001843 [neural tube closure]
GO:0002028 [regulation of sodium ion transport]
GO:0002460 [adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains]
GO:0002513 [tolerance induction to self antigen]
GO:0003179 [heart valve morphogenesis]
GO:0003180 [aortic valve morphogenesis]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006954 [inflammatory response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007492 [endoderm development]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007568 [aging]
GO:0008083 [growth factor activity]
GO:0008283 [cell population proliferation]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008354 [germ cell migration]
GO:0009314 [response to radiation]
GO:0009749 [response to glucose]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010763 [positive regulation of fibroblast migration]
GO:0014003 [oligodendrocyte development]
GO:0014008 [positive regulation of microglia differentiation]
GO:0014070 [response to organic cyclic compound]
GO:0016202 [regulation of striated muscle tissue development]
GO:0021915 [neural tube development]
GO:0030141 [secretory granule]
GO:0030217 [T cell differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030308 [negative regulation of cell growth]
GO:0030316 [osteoclast differentiation]
GO:0030424 [axon]
GO:0030879 [mammary gland development]
GO:0031012 [extracellular matrix]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031100 [animal organ regeneration]
GO:0031536 [positive regulation of exit from mitosis]
GO:0032355 [response to estradiol]
GO:0032667 [regulation of interleukin-23 production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032943 [mononuclear cell proliferation]
GO:0032967 [positive regulation of collagen biosynthetic process]
GO:0033280 [response to vitamin D]
GO:0034616 [response to laminar fluid shear stress]
GO:0035066 [positive regulation of histone acetylation]
GO:0035902 [response to immobilization stress]
GO:0042060 [wound healing]
GO:0042110 [T cell activation]
GO:0042127 [regulation of cell population proliferation]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042306 [regulation of protein import into nucleus]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042482 [positive regulation of odontogenesis]
GO:0042493 [response to drug]
GO:0042552 [myelination]
GO:0042802 [identical protein binding]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043025 [neuronal cell body]
GO:0043029 [T cell homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043129 [surfactant homeostasis]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044877 [protein-containing complex binding]
GO:0045066 [regulatory T cell differentiation]
GO:0045589 [regulation of regulatory T cell differentiation]
GO:0045591 [positive regulation of regulatory T cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046716 [muscle cell cellular homeostasis]
GO:0047485 [protein N-terminus binding]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048286 [lung alveolus development]
GO:0048535 [lymph node development]
GO:0048565 [digestive tract development]
GO:0048839 [inner ear development]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050765 [negative regulation of phagocytosis]
GO:0050777 [negative regulation of immune response]
GO:0050868 [negative regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051098 [regulation of binding]
GO:0051101 [regulation of DNA binding]
GO:0051152 [positive regulation of smooth muscle cell differentiation]
GO:0051280 [negative regulation of release of sequestered calcium ion into cytosol]
GO:0051781 [positive regulation of cell division]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055091 [phospholipid homeostasis]
GO:0060325 [face morphogenesis]
GO:0060364 [frontal suture morphogenesis]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060435 [bronchiole development]
GO:0060744 [mammary gland branching involved in thelarche]
GO:0060751 [branch elongation involved in mammary gland duct branching]
GO:0060762 [regulation of branching involved in mammary gland duct morphogenesis]
GO:0061035 [regulation of cartilage development]
GO:0061448 [connective tissue development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070168 [negative regulation of biomineral tissue development]
GO:0070306 [lens fiber cell differentiation]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071479 [cellular response to ionizing radiation]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071677 [positive regulation of mononuclear cell migration]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0085029 [extracellular matrix assembly]
GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis]
GO:0097421 [liver regeneration]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902074 [response to salt]
GO:1903911 [positive regulation of receptor clustering]
GO:1905313 [transforming growth factor beta receptor signaling pathway involved in heart development]
GO:1990314 [cellular response to insulin-like growth factor stimulus]
GO:1990402 [embryonic liver development]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
390 aa
44.3 kDa
Yes 0
TGFB1-204
ENSP00000504008
ENST00000600196
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Immune system diseases
   Allergies and autoimmune diseases
   Musculoskeletal diseases
   Skeletal diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
Show all
370 aa
40.9 kDa
Yes 0
TGFB1-205
ENSP00000504769
ENST00000677934
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Immune system diseases
   Allergies and autoimmune diseases
   Musculoskeletal diseases
   Skeletal diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
Show all
306 aa
34.2 kDa
Yes 0

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The Human Protein Atlas

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  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.