Protein structure - SCN1B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SCN1B
Synonyms
Gene descriptionⁱ Full gene name according to HGNC.	Sodium voltage-gated channel beta subunit 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes FDA approved drug targets Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Protein evidence	Evidence at protein level (all genes)

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	35030470 - 35040449
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7
Ensembl	ENSG00000105711 (version 103.38)
Entrez gene	6324
HGNC	HGNC:10586
UniProt	Q07699 (UniProt - Evidence at protein level)
neXtProt	NX_Q07699
Antibodypedia	SCN1B antibodies

PROTEIN STRUCTUREⁱ

Predicted

Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1 # Clinical variants: 13 # Population variants: 123

Antigens:

Off

Variants:

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Clinical

Population

Color scheme:

Confidence

Residue index

Chain name

Autorotate:

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PROTEIN BROWSERⁱ

SCN1B-201

SCN1B-202

SCN1B-203

SCN1B-204

SCN1B-206

SCN1B-208

SCN1B-209

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCN1B-201 ENSP00000262631 ENST00000262631	Q07699 [Direct mapping] Sodium channel subunit beta-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005244 [voltage-gated ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0010765 [positive regulation of sodium ion transport] GO:0010976 [positive regulation of neuron projection development] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0019227 [neuronal action potential propagation] GO:0019871 [sodium channel inhibitor activity] GO:0021966 [corticospinal neuron axon guidance] GO:0030315 [T-tubule] GO:0030424 [axon] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0040011 [locomotion] GO:0042995 [cell projection] GO:0043204 [perikaryon] GO:0044325 [ion channel binding] GO:0051899 [membrane depolarization] GO:0060048 [cardiac muscle contraction] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0061337 [cardiac conduction] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086047 [membrane depolarization during Purkinje myocyte cell action potential] GO:0086062 [voltage-gated sodium channel activity involved in Purkinje myocyte action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	218 aa 24.7 kDa	Yes	1
SCN1B-202 ENSP00000396915 ENST00000415950	Q07699 [Direct mapping] Sodium channel subunit beta-1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0002028 [regulation of sodium ion transport] GO:0005244 [voltage-gated ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0010765 [positive regulation of sodium ion transport] GO:0010976 [positive regulation of neuron projection development] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0019227 [neuronal action potential propagation] GO:0019871 [sodium channel inhibitor activity] GO:0021966 [corticospinal neuron axon guidance] GO:0030315 [T-tubule] GO:0030424 [axon] GO:0033268 [node of Ranvier] GO:0034706 [sodium channel complex] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0040011 [locomotion] GO:0042995 [cell projection] GO:0043204 [perikaryon] GO:0044325 [ion channel binding] GO:0046684 [response to pyrethroid] GO:0051899 [membrane depolarization] GO:0060048 [cardiac muscle contraction] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0061337 [cardiac conduction] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086047 [membrane depolarization during Purkinje myocyte cell action potential] GO:0086062 [voltage-gated sodium channel activity involved in Purkinje myocyte action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:1905150 [regulation of voltage-gated sodium channel activity] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	268 aa 30.4 kDa	Yes	0
SCN1B-203 ENSP00000468848 ENST00000595652	B4DI92 [Direct mapping] Sodium channel subunit beta-1; cDNA FLJ55064, moderately similar to Sodium channel beta-1 subunit Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] Show all	147 aa 16.2 kDa	Yes	1
SCN1B-204 ENSP00000492247 ENST00000596348	A0A1W2PR05 [Direct mapping] Sodium channel subunit beta-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005244 [voltage-gated ion channel activity] GO:0005272 [sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] Show all	185 aa 21.5 kDa	No	1
SCN1B-206 ENSP00000492022 ENST00000638536	Q07699 [Direct mapping] Sodium channel subunit beta-1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005244 [voltage-gated ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005272 [sodium channel activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0007155 [cell adhesion] GO:0007411 [axon guidance] GO:0010765 [positive regulation of sodium ion transport] GO:0010976 [positive regulation of neuron projection development] GO:0014704 [intercalated disc] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017080 [sodium channel regulator activity] GO:0019227 [neuronal action potential propagation] GO:0019871 [sodium channel inhibitor activity] GO:0021966 [corticospinal neuron axon guidance] GO:0030315 [T-tubule] GO:0030424 [axon] GO:0033268 [node of Ranvier] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0040011 [locomotion] GO:0042995 [cell projection] GO:0043204 [perikaryon] GO:0044325 [ion channel binding] GO:0051899 [membrane depolarization] GO:0060048 [cardiac muscle contraction] GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0061337 [cardiac conduction] GO:0086002 [cardiac muscle cell action potential involved in contraction] GO:0086006 [voltage-gated sodium channel activity involved in cardiac muscle cell action potential] GO:0086012 [membrane depolarization during cardiac muscle cell action potential] GO:0086047 [membrane depolarization during Purkinje myocyte cell action potential] GO:0086062 [voltage-gated sodium channel activity involved in Purkinje myocyte action potential] GO:0086091 [regulation of heart rate by cardiac conduction] GO:2000649 [regulation of sodium ion transmembrane transporter activity] Show all	218 aa 24.7 kDa	Yes	1
SCN1B-208 ENSP00000492655 ENST00000640135	A0A1W2PS68 [Direct mapping] Sodium channel subunit beta-1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0005244 [voltage-gated ion channel activity] GO:0005272 [sodium channel activity] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0016020 [membrane] GO:0017080 [sodium channel regulator activity] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] Show all	235 aa 27.2 kDa	No	0
SCN1B-209 ENSP00000502395 ENST00000675741		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Human disease related genes Cardiovascular diseases Cardiac diseases Nervous system diseases Epilepsy Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0006814 [sodium ion transport] GO:0017080 [sodium channel regulator activity] Show all	227 aa 26.4 kDa	No	1