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GATA3
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  • GATA3
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

GATA3
Synonyms HDR
Gene descriptioni

Full gene name according to HGNC.

GATA binding protein 3
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 10
Cytoband p14
Chromosome location (bp) 8045378 - 8075198
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000107485 (version 103.38)
Entrez gene 2625
HGNC HGNC:4172
UniProt P23771 (UniProt - Evidence at protein level)
neXtProt NX_P23771
Antibodypedia GATA3 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 4      # Population variants: 268

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
GATA3-201
GATA3-202
GATA3-204
GATA3-205


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
GATA3-201
ENSP00000341619
ENST00000346208
P23771 [Direct mapping]
Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001709 [cell fate determination]
GO:0001817 [regulation of cytokine production]
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0002376 [immune system process]
GO:0002520 [immune system development]
GO:0003180 [aortic valve morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003281 [ventricular septum development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006952 [defense response]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008584 [male gonad development]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0009967 [positive regulation of signal transduction]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016579 [protein deubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030217 [T cell differentiation]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0031929 [TOR signaling]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033600 [negative regulation of mammary gland epithelial cell proliferation]
GO:0035457 [cellular response to interferon-alpha]
GO:0042421 [norepinephrine biosynthetic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043583 [ear development]
GO:0043627 [response to estrogen]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048485 [sympathetic nervous system development]
GO:0048568 [embryonic organ development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0050728 [negative regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060037 [pharyngeal system development]
GO:0060065 [uterus development]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060676 [ureteric bud formation]
GO:0061290 [canonical Wnt signaling pathway involved in metanephric kidney development]
GO:0070888 [E-box binding]
GO:0071353 [cellular response to interleukin-4]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071837 [HMG box domain binding]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0072178 [nephric duct morphogenesis]
GO:0072179 [nephric duct formation]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072676 [lymphocyte migration]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000146 [negative regulation of cell motility]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000607 [negative regulation of cell proliferation involved in mesonephros development]
GO:2000611 [positive regulation of thyroid hormone generation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000683 [regulation of cellular response to X-ray]
GO:2000703 [negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation]
GO:2000734 [negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation]
Show all
443 aa
47.9 kDa
No 0
GATA3-202
ENSP00000368632
ENST00000379328
P23771 [Direct mapping]
Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000902 [cell morphogenesis]
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001701 [in utero embryonic development]
GO:0001709 [cell fate determination]
GO:0001764 [neuron migration]
GO:0001775 [cell activation]
GO:0001806 [type IV hypersensitivity]
GO:0001817 [regulation of cytokine production]
GO:0001819 [positive regulation of cytokine production]
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0002088 [lens development in camera-type eye]
GO:0002376 [immune system process]
GO:0002520 [immune system development]
GO:0002572 [pro-T cell differentiation]
GO:0003180 [aortic valve morphogenesis]
GO:0003215 [cardiac right ventricle morphogenesis]
GO:0003281 [ventricular septum development]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005134 [interleukin-2 receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006952 [defense response]
GO:0006959 [humoral immune response]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008584 [male gonad development]
GO:0009615 [response to virus]
GO:0009653 [anatomical structure morphogenesis]
GO:0009791 [post-embryonic development]
GO:0009967 [positive regulation of signal transduction]
GO:0010332 [response to gamma radiation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010975 [regulation of neuron projection development]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016579 [protein deubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030182 [neuron differentiation]
GO:0030217 [T cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0030856 [regulation of epithelial cell differentiation]
GO:0031929 [TOR signaling]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032703 [negative regulation of interleukin-2 production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033077 [T cell differentiation in thymus]
GO:0033600 [negative regulation of mammary gland epithelial cell proliferation]
GO:0035162 [embryonic hemopoiesis]
GO:0035457 [cellular response to interferon-alpha]
GO:0035799 [ureter maturation]
GO:0035898 [parathyroid hormone secretion]
GO:0042421 [norepinephrine biosynthetic process]
GO:0042472 [inner ear morphogenesis]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043370 [regulation of CD4-positive, alpha-beta T cell differentiation]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043583 [ear development]
GO:0043627 [response to estrogen]
GO:0045061 [thymic T cell selection]
GO:0045064 [T-helper 2 cell differentiation]
GO:0045087 [innate immune response]
GO:0045165 [cell fate commitment]
GO:0045471 [response to ethanol]
GO:0045582 [positive regulation of T cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
GO:0048469 [cell maturation]
GO:0048485 [sympathetic nervous system development]
GO:0048538 [thymus development]
GO:0048568 [embryonic organ development]
GO:0048589 [developmental growth]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048872 [homeostasis of number of cells]
GO:0050728 [negative regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051569 [regulation of histone H3-K4 methylation]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060017 [parathyroid gland development]
GO:0060037 [pharyngeal system development]
GO:0060065 [uterus development]
GO:0060231 [mesenchymal to epithelial transition]
GO:0060374 [mast cell differentiation]
GO:0060676 [ureteric bud formation]
GO:0061085 [regulation of histone H3-K27 methylation]
GO:0061290 [canonical Wnt signaling pathway involved in metanephric kidney development]
GO:0070888 [E-box binding]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071353 [cellular response to interleukin-4]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071442 [positive regulation of histone H3-K14 acetylation]
GO:0071599 [otic vesicle development]
GO:0071773 [cellular response to BMP stimulus]
GO:0071837 [HMG box domain binding]
GO:0072107 [positive regulation of ureteric bud formation]
GO:0072178 [nephric duct morphogenesis]
GO:0072179 [nephric duct formation]
GO:0072182 [regulation of nephron tubule epithelial cell differentiation]
GO:0072197 [ureter morphogenesis]
GO:0072676 [lymphocyte migration]
GO:0090102 [cochlea development]
GO:1901536 [negative regulation of DNA demethylation]
GO:1902036 [regulation of hematopoietic stem cell differentiation]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1990837 [sequence-specific double-stranded DNA binding]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000146 [negative regulation of cell motility]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000553 [positive regulation of T-helper 2 cell cytokine production]
GO:2000607 [negative regulation of cell proliferation involved in mesonephros development]
GO:2000611 [positive regulation of thyroid hormone generation]
GO:2000617 [positive regulation of histone H3-K9 acetylation]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
GO:2000683 [regulation of cellular response to X-ray]
GO:2000703 [negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation]
GO:2000734 [negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation]
Show all
444 aa
48 kDa
No 0
GATA3-204
ENSP00000493486
ENST00000481743
A0A2R8Y2A9 [Direct mapping]
Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008270 [zinc ion binding]
GO:0045582 [positive regulation of T cell differentiation]
Show all
143 aa
15.5 kDa
No 0
GATA3-205
ENSP00000494284
ENST00000643001
A0A2R8Y4T2 [Direct mapping]
Trans-acting T-cell-specific transcription factor GATA-3
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Frameshift Mutations
Human disease related genes
   Congenital malformations
   Other congenital malformations
   Immune system diseases
   Allergies and autoimmune diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0008270 [zinc ion binding]
GO:0045582 [positive regulation of T cell differentiation]
Show all
80 aa
9.1 kDa
No 0

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.