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FGF8
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  • FGF8
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FGF8
Synonyms AIGF
Gene descriptioni

Full gene name according to HGNC.

Fibroblast growth factor 8
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Human disease related genes
RAS pathway related proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 10
Cytoband q24.32
Chromosome location (bp) 101770130 - 101780369
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000107831 (version 103.38)
Entrez gene 2253
HGNC HGNC:3686
UniProt P55075 (UniProt - Evidence at protein level)
neXtProt NX_P55075
Antibodypedia FGF8 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 5      # Population variants: 147

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
FGF8-201
FGF8-202
FGF8-203
FGF8-204
FGF8-207


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FGF8-201
ENSP00000321797
ENST00000320185
P55075 [Direct mapping]
Fibroblast growth factor 8
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Hypothalamus and pituitary gland diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000165 [MAPK cascade]
GO:0001569 [branching involved in blood vessel morphogenesis]
GO:0001656 [metanephros development]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001759 [organ induction]
GO:0001822 [kidney development]
GO:0001823 [mesonephros development]
GO:0001839 [neural plate morphogenesis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001947 [heart looping]
GO:0001974 [blood vessel remodeling]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003151 [outflow tract morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005111 [type 2 fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0006979 [response to oxidative stress]
GO:0007275 [multicellular organism development]
GO:0007368 [determination of left/right symmetry]
GO:0007369 [gastrulation]
GO:0007507 [heart development]
GO:0008045 [motor neuron axon guidance]
GO:0008078 [mesodermal cell migration]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008406 [gonad development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0009887 [animal organ morphogenesis]
GO:0009897 [external side of plasma membrane]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010628 [positive regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0021537 [telencephalon development]
GO:0021543 [pallium development]
GO:0021544 [subpallium development]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0021846 [cell proliferation in forebrain]
GO:0021884 [forebrain neuron development]
GO:0021954 [central nervous system neuron development]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030324 [lung development]
GO:0030334 [regulation of cell migration]
GO:0030539 [male genitalia development]
GO:0030878 [thyroid gland development]
GO:0030916 [otic vesicle formation]
GO:0030917 [midbrain-hindbrain boundary development]
GO:0033563 [dorsal/ventral axon guidance]
GO:0035050 [embryonic heart tube development]
GO:0035108 [limb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0035909 [aorta morphogenesis]
GO:0042056 [chemoattractant activity]
GO:0042472 [inner ear morphogenesis]
GO:0042476 [odontogenesis]
GO:0042487 [regulation of odontogenesis of dentin-containing tooth]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045165 [cell fate commitment]
GO:0045597 [positive regulation of cell differentiation]
GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0046622 [positive regulation of organ growth]
GO:0048699 [generation of neurons]
GO:0048702 [embryonic neurocranium morphogenesis]
GO:0048853 [forebrain morphogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050918 [positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055026 [negative regulation of cardiac muscle tissue development]
GO:0060037 [pharyngeal system development]
GO:0060128 [corticotropin hormone secreting cell differentiation]
GO:0060129 [thyroid-stimulating hormone-secreting cell differentiation]
GO:0060348 [bone development]
GO:0060425 [lung morphogenesis]
GO:0060445 [branching involved in salivary gland morphogenesis]
GO:0060563 [neuroepithelial cell differentiation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071542 [dopaminergic neuron differentiation]
GO:0090134 [cell migration involved in mesendoderm migration]
GO:0120223 [larynx morphogenesis]
Show all
244 aa
27.7 kDa
Yes 0
FGF8-202
ENSP00000340039
ENST00000344255
P55075 [Direct mapping]
Fibroblast growth factor 8
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Hypothalamus and pituitary gland diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000165 [MAPK cascade]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005111 [type 2 fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organism development]
GO:0007369 [gastrulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008406 [gonad development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [animal organ morphogenesis]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030334 [regulation of cell migration]
GO:0035050 [embryonic heart tube development]
GO:0035108 [limb morphogenesis]
GO:0042476 [odontogenesis]
GO:0045597 [positive regulation of cell differentiation]
GO:0050918 [positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055026 [negative regulation of cardiac muscle tissue development]
GO:0060348 [bone development]
GO:0060563 [neuroepithelial cell differentiation]
GO:0071542 [dopaminergic neuron differentiation]
Show all
233 aa
26.5 kDa
Yes 0
FGF8-203
ENSP00000344306
ENST00000346714
P55075 [Direct mapping]
Fibroblast growth factor 8
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Hypothalamus and pituitary gland diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000165 [MAPK cascade]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005111 [type 2 fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organism development]
GO:0007369 [gastrulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008406 [gonad development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [animal organ morphogenesis]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030334 [regulation of cell migration]
GO:0035050 [embryonic heart tube development]
GO:0035108 [limb morphogenesis]
GO:0042476 [odontogenesis]
GO:0045597 [positive regulation of cell differentiation]
GO:0050918 [positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055026 [negative regulation of cardiac muscle tissue development]
GO:0060348 [bone development]
GO:0060563 [neuroepithelial cell differentiation]
GO:0071542 [dopaminergic neuron differentiation]
Show all
204 aa
23.5 kDa
Yes 0
FGF8-204
ENSP00000321945
ENST00000347978
P55075 [Direct mapping]
Fibroblast growth factor 8
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Hypothalamus and pituitary gland diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000165 [MAPK cascade]
GO:0001656 [metanephros development]
GO:0001823 [mesonephros development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003007 [heart morphogenesis]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005105 [type 1 fibroblast growth factor receptor binding]
GO:0005111 [type 2 fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organism development]
GO:0007369 [gastrulation]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008406 [gonad development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0009887 [animal organ morphogenesis]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030334 [regulation of cell migration]
GO:0035050 [embryonic heart tube development]
GO:0035108 [limb morphogenesis]
GO:0042476 [odontogenesis]
GO:0045597 [positive regulation of cell differentiation]
GO:0050918 [positive chemotaxis]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055026 [negative regulation of cardiac muscle tissue development]
GO:0060348 [bone development]
GO:0060563 [neuroepithelial cell differentiation]
GO:0071542 [dopaminergic neuron differentiation]
Show all
215 aa
24.7 kDa
Yes 0
FGF8-207
ENSP00000484420
ENST00000618991
A0A087X1S5 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
RAS pathway related proteins
Human disease related genes
   Endocrine and metabolic diseases
   Hypothalamus and pituitary gland diseases
Show all
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005576 [extracellular region]
GO:0008083 [growth factor activity]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
Show all
140 aa
16.3 kDa
No 0

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The Human Protein Atlas project is funded
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