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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
q24.32
Chromosome location (bp)
101770130 - 101780369
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
FGF8-201
FGF8-202
FGF8-203
FGF8-204
FGF8-207
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000165 [MAPK cascade] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001656 [metanephros development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0001759 [organ induction] GO:0001822 [kidney development] GO:0001823 [mesonephros development] GO:0001839 [neural plate morphogenesis] GO:0001934 [positive regulation of protein phosphorylation] GO:0001947 [heart looping] GO:0001974 [blood vessel remodeling] GO:0003007 [heart morphogenesis] GO:0003148 [outflow tract septum morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation] GO:0005104 [fibroblast growth factor receptor binding] GO:0005105 [type 1 fibroblast growth factor receptor binding] GO:0005111 [type 2 fibroblast growth factor receptor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0006979 [response to oxidative stress] GO:0007275 [multicellular organism development] GO:0007368 [determination of left/right symmetry] GO:0007369 [gastrulation] GO:0007507 [heart development] GO:0008045 [motor neuron axon guidance] GO:0008078 [mesodermal cell migration] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell population proliferation] GO:0008406 [gonad development] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0009792 [embryo development ending in birth or egg hatching] GO:0009887 [animal organ morphogenesis] GO:0009897 [external side of plasma membrane] GO:0009953 [dorsal/ventral pattern formation] GO:0010628 [positive regulation of gene expression] GO:0014070 [response to organic cyclic compound] GO:0021537 [telencephalon development] GO:0021543 [pallium development] GO:0021544 [subpallium development] GO:0021798 [forebrain dorsal/ventral pattern formation] GO:0021846 [cell proliferation in forebrain] GO:0021884 [forebrain neuron development] GO:0021954 [central nervous system neuron development] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030154 [cell differentiation] GO:0030182 [neuron differentiation] GO:0030324 [lung development] GO:0030334 [regulation of cell migration] GO:0030539 [male genitalia development] GO:0030878 [thyroid gland development] GO:0030916 [otic vesicle formation] GO:0030917 [midbrain-hindbrain boundary development] GO:0033563 [dorsal/ventral axon guidance] GO:0035050 [embryonic heart tube development] GO:0035108 [limb morphogenesis] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035909 [aorta morphogenesis] GO:0042056 [chemoattractant activity] GO:0042472 [inner ear morphogenesis] GO:0042476 [odontogenesis] GO:0042487 [regulation of odontogenesis of dentin-containing tooth] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045165 [cell fate commitment] GO:0045597 [positive regulation of cell differentiation] GO:0045745 [positive regulation of G protein-coupled receptor signaling pathway] GO:0045840 [positive regulation of mitotic nuclear division] GO:0046622 [positive regulation of organ growth] GO:0048699 [generation of neurons] GO:0048702 [embryonic neurocranium morphogenesis] GO:0048853 [forebrain morphogenesis] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918 [positive chemotaxis] GO:0051781 [positive regulation of cell division] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055026 [negative regulation of cardiac muscle tissue development] GO:0060037 [pharyngeal system development] GO:0060128 [corticotropin hormone secreting cell differentiation] GO:0060129 [thyroid-stimulating hormone-secreting cell differentiation] GO:0060348 [bone development] GO:0060425 [lung morphogenesis] GO:0060445 [branching involved in salivary gland morphogenesis] GO:0060563 [neuroepithelial cell differentiation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071542 [dopaminergic neuron differentiation] GO:0090134 [cell migration involved in mesendoderm migration] GO:0120223 [larynx morphogenesis]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases Mapped to neXtProt neXtProt - Evidence at protein level
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Endocrine and metabolic diseases Hypothalamus and pituitary gland diseases