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RPS6KB1
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  • RPS6KB1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

RPS6KB1
Synonyms p70(S6K)-alpha, PS6K, S6K, S6K1, STK14A
Gene descriptioni

Full gene name according to HGNC.

Ribosomal protein S6 kinase B1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Enzymes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 17
Cytoband q23.1
Chromosome location (bp) 59893046 - 59950574
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000108443 (version 103.38)
Entrez gene 6198
HGNC HGNC:10436
UniProt P23443 (UniProt - Evidence at protein level)
neXtProt NX_P23443
Antibodypedia RPS6KB1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 118

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
RPS6KB1-201
RPS6KB1-202
RPS6KB1-203
RPS6KB1-204
RPS6KB1-212


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
RPS6KB1-201
ENSP00000225577
ENST00000225577
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0001662 [behavioral fear response]
GO:0003009 [skeletal muscle contraction]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007281 [germ cell development]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007616 [long-term memory]
GO:0009408 [response to heat]
GO:0009611 [response to wounding]
GO:0009612 [response to mechanical stimulus]
GO:0009636 [response to toxic substance]
GO:0009749 [response to glucose]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010243 [response to organonitrogen compound]
GO:0014070 [response to organic cyclic compound]
GO:0014732 [skeletal muscle atrophy]
GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030054 [cell junction]
GO:0030165 [PDZ domain binding]
GO:0031667 [response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0032496 [response to lipopolysaccharide]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0032870 [cellular response to hormone stimulus]
GO:0033574 [response to testosterone]
GO:0033762 [response to glucagon]
GO:0034612 [response to tumor necrosis factor]
GO:0042277 [peptide binding]
GO:0042493 [response to drug]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043200 [response to amino acid]
GO:0043201 [response to leucine]
GO:0043434 [response to peptide hormone]
GO:0043491 [protein kinase B signaling]
GO:0044539 [long-chain fatty acid import into cell]
GO:0045202 [synapse]
GO:0045471 [response to ethanol]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046324 [regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048633 [positive regulation of skeletal muscle tissue growth]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051384 [response to glucocorticoid]
GO:0051721 [protein phosphatase 2A binding]
GO:0071346 [cellular response to interferon-gamma]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0106310 []
GO:0106311 []
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
Show all
525 aa
59.1 kDa
No 0
RPS6KB1-202
ENSP00000376744
ENST00000393021
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030054 [cell junction]
GO:0031667 [response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0044539 [long-chain fatty acid import into cell]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071363 [cellular response to growth factor stimulus]
GO:0106310 []
GO:0106311 []
Show all
472 aa
53 kDa
No 0
RPS6KB1-203
ENSP00000384335
ENST00000406116
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030054 [cell junction]
GO:0031667 [response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0044539 [long-chain fatty acid import into cell]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071363 [cellular response to growth factor stimulus]
GO:0106310 []
GO:0106311 []
Show all
451 aa
51 kDa
No 0
RPS6KB1-204
ENSP00000441993
ENST00000443572
P23443 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004711 [ribosomal protein S6 kinase activity]
GO:0004712 [protein serine/threonine/tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030054 [cell junction]
GO:0031667 [response to nutrient levels]
GO:0031929 [TOR signaling]
GO:0032869 [cellular response to insulin stimulus]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0044539 [long-chain fatty acid import into cell]
GO:0045202 [synapse]
GO:0045727 [positive regulation of translation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045948 [positive regulation of translational initiation]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0071363 [cellular response to growth factor stimulus]
GO:0106310 []
GO:0106311 []
Show all
502 aa
56.6 kDa
No 0
RPS6KB1-212
ENSP00000464805
ENST00000592726
K7EIM2 [Direct mapping]
Ribosomal protein S6 kinase beta-1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
62 aa
6.9 kDa
No 0

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  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
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  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.