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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:45.4 nTPM
HPA:45.4 nTPM
GTEx:15.5 nTPM
FANTOM5:193.5 Scaled Tags Per Million
Pig:46.0 nTPM
Mouse:25.0 nTPM
Allen mouse:1.1 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 45.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 32.2
1830 Male, age 51, unknown 53.8
1833 Male, age 53, unknown 45.4
1870 Female, age 42, unknown 43.7
2411 Female, age 72, unknown 36.2
2019 Male, age 18, unknown 35.1
2666 Male, age 74, left hemisphere 29.5
2828 Female, age 72, unknown 24.8
2219 Male, age 76, both hemispheres 21.2
2586 Male, age 75, left hemisphere 17.5
1827 Male, age 72, unknown 15.1
Dorsal raphe nucleus
nTPM: 15.8
2750 Male, age 76, both hemispheres 34.6
2016 Female, age 72, unknown 20.6
1828 Male, age 53, unknown 17.2
2047 Male, age 72, unknown 5.7
2298 Female, age 72, unknown 0.8
Inferior colliculus
nTPM: 17.3
1890 Male, age 53, unknown 23.3
2849 Male, age 72, unknown 19.8
1848 Female, age 42, unknown 16.1
2097 Female, age 72, unknown 9.9
Median raphe nucleus
nTPM: 13.8
2220 Male, age 76, midline 13.8
Pedunculopontine tegmental nucleus
nTPM: 23.8
2334 Male, age 80, both hemispheres 28.1
2338 Male, age 61, both hemispheres 25.7
1921 Female, age 85, both hemispheres 17.7
Periaquaductal grey, anterior
nTPM: 11.1
2502 Female, age 75, unknown 17.4
1947 Male, age 18, unknown 14.9
1795 Male, age 51, unknown 0.9
Periaquaductal grey, dorsal
nTPM: 11.9
2464 Female, age 72, unknown 19.1
2850 Male, age 76, both hemispheres 15.7
1831 Male, age 72, unknown 11.3
1840 Male, age 53, unknown 1.3
Periaquaductal grey, lateral
nTPM: 14.0
2053 Male, age 18, unknown 16.6
2140 Male, age 76, both hemispheres 15.2
2272 Male, age 74, both hemispheres 10.1
Pretectal area
nTPM: 13.5
2316 Male, age 76, right hemisphere 25.3
1815 Male, age 53, unknown 23.9
2407 Male, age 75, both hemispheres 23.8
2825 Male, age 18, unknown 15.2
1817 Female, age 42, unknown 13.2
2007 Male, age 72, unknown 12.3
2667 Female, age 75, unknown 10.3
1944 Female, age 72, unknown 8.1
2273 Male, age 74, both hemispheres 7.7
2224 Female, age 72, unknown 7.6
1816 Male, age 51, unknown 1.3
Red nucleus
nTPM: 45.4
1865 Male, age 51, unknown 65.6
1904 Male, age 53, unknown 54.5
2503 Female, age 72, unknown 51.2
1821 Female, age 72, unknown 50.8
2769 Male, age 72, unknown 49.2
2227 Male, age 72, unknown 46.6
2785 Male, age 18, unknown 46.4
1954 Female, age 42, unknown 44.8
2823 Male, age 76, right hemisphere 42.0
2588 Male, age 74, left hemisphere 38.9
2725 Female, age 75, unknown 31.1
2584 Male, age 75, left hemisphere 23.4
Substantia nigra
nTPM: 23.5
2409 Female, age 72, unknown 40.5
2699 Male, age 18, unknown 33.9
2590 Female, age 75, unknown 27.4
2583 Male, age 75, right hemisphere 26.5
1851 Male, age 51, unknown 25.4
2241 Male, age 72, unknown 22.5
1889 Female, age 72, unknown 20.8
2665 Male, age 74, both hemispheres 16.1
1941 Male, age 53, unknown 13.2
1916 Female, age 42, unknown 8.4
Superior colliculus
nTPM: 25.6
1913 Female, age 42, unknown 56.8
1995 Male, age 72, unknown 48.6
1895 Male, age 76, right hemisphere 33.8
2587 Male, age 74, left hemisphere 28.5
1839 Male, age 51, unknown 27.4
2668 Female, age 75, unknown 23.9
1796 Male, age 53, unknown 12.3
2087 Female, age 72, unknown 11.9
2664 Male, age 75, both hemispheres 10.5
2261 Male, age 18, unknown 2.2
Ventral tegmental area
nTPM: 23.5
2223 Female, age 72, unknown 34.1
2410 Female, age 72, unknown 32.1
2218 Male, age 76, both hemispheres 20.6
2021 Male, age 53, unknown 20.5
1942 Male, age 51, unknown 18.0
1915 Female, age 42, unknown 15.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 15.5
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 15.5
Samples: 139

Max nTPM: 43.6
Min nTPM: 5.3
Std nTPM: 6.5
Median nTPM: 14.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 43.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 39.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 34.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 33.4
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 31.5
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 31.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 29.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 28.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 28.2
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 27.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 27.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 26.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 26.7
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 25.2
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 25.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 23.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 22.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 22.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 22.4
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 21.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 20.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 20.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 20.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 20.1
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 19.3
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 19.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 18.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 18.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 18.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 18.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 18.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 17.9
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 17.8
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 17.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 17.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 17.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 17.6
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 17.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 17.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 17.0
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 17.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 16.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 16.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 16.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 16.6
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 16.3
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 16.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 16.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 16.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 16.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 16.1
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 16.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 15.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 15.8
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 15.5
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 15.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 15.2
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 15.1
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 15.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 15.1
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 15.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 15.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 14.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 14.8
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 14.6
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 14.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 14.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 14.5
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 14.4
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 14.2
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 14.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 14.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 13.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 13.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 13.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 13.6
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 13.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 13.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 13.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 13.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 13.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 13.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 13.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 13.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 13.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 13.0
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 12.8
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 12.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 12.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 12.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 12.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 12.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 12.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 12.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 11.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 11.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 11.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 11.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 11.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 11.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 11.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 11.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 11.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 11.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 11.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 11.0
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 10.9
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 10.9
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 10.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 10.5
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 10.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 10.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 10.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 10.3
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 10.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 10.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 10.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 10.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 9.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 9.5
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 9.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 9.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 9.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 8.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 8.7
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 8.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 8.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 8.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 8.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 8.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 8.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 8.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 8.0
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 7.7
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 7.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 7.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 7.0
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 5.3
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 5.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 193.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 193.5
FF:10158-103A5 76 years, female 193.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 46.0
Pig sample Sample description nTPM
Midbrain
nTPM: 46.0
Samples: 4

Max nTPM: 83.1
Min nTPM: 27.4
Sample A Female 83.1
Sample B Female 44.7
Sample C Male 28.9
Sample D Male 27.4
Periaqueductal gray
nTPM: 33.0
Samples: 3

Max nTPM: 37.5
Min nTPM: 25.8
Sample B Female 37.5
Sample C Male 25.8
Sample D Male 35.7
Substantia nigra
nTPM: 44.0
Samples: 4

Max nTPM: 70.6
Min nTPM: 31.3
Sample A Female 36.3
Sample B Female 31.3
Sample C Male 37.7
Sample D Male 70.6
Superior colliculi
nTPM: 34.4
Samples: 4

Max nTPM: 42.8
Min nTPM: 23.0
Sample A Female 34.4
Sample B Female 23.0
Sample C Male 37.5
Sample D Male 42.8

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 25.0
Mouse sample Sample description nTPM
Midbrain
nTPM: 25.0
Samples: 4

Max nTPM: 26.2
Min nTPM: 23.4
Sample A Male 23.4
Sample B Male 25.7
Sample C Female 26.2
Sample D Female 24.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 1.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 1.1
71735832 Antisense, RP_051010_03_C06, Mouse strain C57BL/6J (56 days, male) 1.1

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