We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
p15.2
Chromosome location (bp)
23755041 - 23904089
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PPARGC1A-201
PPARGC1A-206
PPARGC1A-216
PPARGC1A-217
PPARGC1A-218
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000302 [response to reactive oxygen species] GO:0000422 [autophagy of mitochondrion] GO:0000785 [chromatin] GO:0001659 [temperature homeostasis] GO:0001666 [response to hypoxia] GO:0001678 [cellular glucose homeostasis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002021 [response to dietary excess] GO:0002931 [response to ischemia] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription coregulator activity] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0005102 [signaling receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006012 [galactose metabolic process] GO:0006094 [gluconeogenesis] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006397 [mRNA processing] GO:0007005 [mitochondrion organization] GO:0007568 [aging] GO:0007586 [digestion] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0008209 [androgen metabolic process] GO:0008380 [RNA splicing] GO:0009409 [response to cold] GO:0009750 [response to fructose] GO:0010628 [positive regulation of gene expression] GO:0010822 [positive regulation of mitochondrion organization] GO:0014070 [response to organic cyclic compound] GO:0014732 [skeletal muscle atrophy] GO:0014823 [response to activity] GO:0014850 [response to muscle activity] GO:0014878 [response to electrical stimulus involved in regulation of muscle adaptation] GO:0014912 [negative regulation of smooth muscle cell migration] GO:0016605 [PML body] GO:0016922 [nuclear receptor binding] GO:0019395 [fatty acid oxidation] GO:0021549 [cerebellum development] GO:0022626 [cytosolic ribosome] GO:0022904 [respiratory electron transport chain] GO:0030331 [estrogen receptor binding] GO:0030374 [nuclear receptor transcription coactivator activity] GO:0030900 [forebrain development] GO:0031325 [positive regulation of cellular metabolic process] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0031667 [response to nutrient levels] GO:0032922 [circadian regulation of gene expression] GO:0034599 [cellular response to oxidative stress] GO:0035066 [positive regulation of histone acetylation] GO:0035865 [cellular response to potassium ion] GO:0042493 [response to drug] GO:0042594 [response to starvation] GO:0042752 [regulation of circadian rhythm] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043014 [alpha-tubulin binding] GO:0043025 [neuronal cell body] GO:0043201 [response to leucine] GO:0043231 [intracellular membrane-bounded organelle] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045333 [cellular respiration] GO:0045722 [positive regulation of gluconeogenesis] GO:0045820 [negative regulation of glycolytic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046321 [positive regulation of fatty acid oxidation] GO:0048511 [rhythmic process] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050821 [protein stabilization] GO:0050873 [brown fat cell differentiation] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051552 [flavone metabolic process] GO:0051602 [response to electrical stimulus] GO:0060612 [adipose tissue development] GO:0065003 [protein-containing complex assembly] GO:0071222 [cellular response to lipopolysaccharide] GO:0071250 [cellular response to nitrite] GO:0071313 [cellular response to caffeine] GO:0071332 [cellular response to fructose stimulus] GO:0071333 [cellular response to glucose stimulus] GO:0071354 [cellular response to interleukin-6] GO:0071356 [cellular response to tumor necrosis factor] GO:0071372 [cellular response to follicle-stimulating hormone stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0071398 [cellular response to fatty acid] GO:0071456 [cellular response to hypoxia] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0071871 [response to epinephrine] GO:0071873 [response to norepinephrine] GO:0090258 [negative regulation of mitochondrial fission] GO:0097009 [energy homeostasis] GO:0097066 [response to thyroid hormone] GO:0097067 [cellular response to thyroid hormone stimulus] GO:0097440 [apical dendrite] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1901215 [negative regulation of neuron death] GO:1901558 [response to metformin] GO:1901857 [positive regulation of cellular respiration] GO:1901860 [positive regulation of mitochondrial DNA metabolic process] GO:1901863 [positive regulation of muscle tissue development] GO:1904635 [positive regulation of glomerular visceral epithelial cell apoptotic process] GO:1904637 [cellular response to ionomycin] GO:1904639 [cellular response to resveratrol] GO:1904640 [response to methionine] GO:1990841 [promoter-specific chromatin binding] GO:1990843 [subsarcolemmal mitochondrion] GO:1990844 [interfibrillar mitochondrion] GO:1990845 [adaptive thermogenesis] GO:2000184 [positive regulation of progesterone biosynthetic process] GO:2000272 [negative regulation of signaling receptor activity] GO:2000310 [regulation of NMDA receptor activity] GO:2001171 [positive regulation of ATP biosynthetic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000785 [chromatin] GO:0001659 [temperature homeostasis] GO:0001678 [cellular glucose homeostasis] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003712 [transcription coregulator activity] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0005102 [signaling receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006094 [gluconeogenesis] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006397 [mRNA processing] GO:0007005 [mitochondrion organization] GO:0007586 [digestion] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0008380 [RNA splicing] GO:0010628 [positive regulation of gene expression] GO:0010822 [positive regulation of mitochondrion organization] GO:0014850 [response to muscle activity] GO:0016605 [PML body] GO:0016922 [nuclear receptor binding] GO:0019395 [fatty acid oxidation] GO:0022904 [respiratory electron transport chain] GO:0030374 [nuclear receptor transcription coactivator activity] GO:0031490 [chromatin DNA binding] GO:0031625 [ubiquitin protein ligase binding] GO:0032922 [circadian regulation of gene expression] GO:0034599 [cellular response to oxidative stress] GO:0035066 [positive regulation of histone acetylation] GO:0042594 [response to starvation] GO:0042752 [regulation of circadian rhythm] GO:0043231 [intracellular membrane-bounded organelle] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045333 [cellular respiration] GO:0045722 [positive regulation of gluconeogenesis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046321 [positive regulation of fatty acid oxidation] GO:0048511 [rhythmic process] GO:0050821 [protein stabilization] GO:0050873 [brown fat cell differentiation] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0065003 [protein-containing complex assembly] GO:0097009 [energy homeostasis] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1901215 [negative regulation of neuron death] GO:2001171 [positive regulation of ATP biosynthetic process]