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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.31
Chromosome location (bp)
36027677 - 36111236
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MAPK14-201
MAPK14-202
MAPK14-203
MAPK14-204
MAPK14-205
MAPK14-210
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q16539 [Direct mapping] Mitogen-activated protein kinase 14 A0A024RD15 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase 14
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0032735 [positive regulation of interleukin-12 production] GO:0034774 [secretory granule lumen] GO:0035331 [negative regulation of hippo signaling] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038066 [p38MAPK cascade] GO:0042770 [signal transduction in response to DNA damage] GO:0043312 [neutrophil degranulation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048273 [mitogen-activated protein kinase p38 binding] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051525 [NFAT protein binding] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071479 [cellular response to ionizing radiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904813 [ficolin-1-rich granule lumen] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Q16539 [Direct mapping] Mitogen-activated protein kinase 14 L7RSM2 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase 14
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000077 [DNA damage checkpoint] GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0000902 [cell morphogenesis] GO:0000922 [spindle pole] GO:0001502 [cartilage condensation] GO:0001525 [angiogenesis] GO:0001890 [placenta development] GO:0002062 [chondrocyte differentiation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006006 [glucose metabolic process] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006935 [chemotaxis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007519 [skeletal muscle tissue development] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019395 [fatty acid oxidation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030278 [regulation of ossification] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032495 [response to muramyl dipeptide] GO:0032496 [response to lipopolysaccharide] GO:0032735 [positive regulation of interleukin-12 production] GO:0034774 [secretory granule lumen] GO:0035331 [negative regulation of hippo signaling] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0035994 [response to muscle stretch] GO:0038066 [p38MAPK cascade] GO:0042307 [positive regulation of protein import into nucleus] GO:0042770 [signal transduction in response to DNA damage] GO:0043312 [neutrophil degranulation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046326 [positive regulation of glucose import] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048273 [mitogen-activated protein kinase p38 binding] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051146 [striated muscle cell differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051525 [NFAT protein binding] GO:0060045 [positive regulation of cardiac muscle cell proliferation] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071356 [cellular response to tumor necrosis factor] GO:0071479 [cellular response to ionizing radiation] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090336 [positive regulation of brown fat cell differentiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:0098978 [glutamatergic synapse] GO:0099179 [regulation of synaptic membrane adhesion] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904813 [ficolin-1-rich granule lumen] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Q16539 [Direct mapping] Mitogen-activated protein kinase 14
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0000187 [activation of MAPK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0004708 [MAP kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010831 [positive regulation of myotube differentiation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016607 [nuclear speck] GO:0016740 [transferase activity] GO:0018105 [peptidyl-serine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030316 [osteoclast differentiation] GO:0031281 [positive regulation of cyclase activity] GO:0032735 [positive regulation of interleukin-12 production] GO:0034774 [secretory granule lumen] GO:0035331 [negative regulation of hippo signaling] GO:0035556 [intracellular signal transduction] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0038066 [p38MAPK cascade] GO:0042770 [signal transduction in response to DNA damage] GO:0043312 [neutrophil degranulation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048273 [mitogen-activated protein kinase p38 binding] GO:0051090 [regulation of DNA-binding transcription factor activity] GO:0051149 [positive regulation of muscle cell differentiation] GO:0051525 [NFAT protein binding] GO:0070935 [3'-UTR-mediated mRNA stabilization] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071479 [cellular response to ionizing radiation] GO:0090400 [stress-induced premature senescence] GO:0098586 [cellular response to virus] GO:1900015 [regulation of cytokine production involved in inflammatory response] GO:1901741 [positive regulation of myoblast fusion] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1904813 [ficolin-1-rich granule lumen] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
B4E0K5 [Direct mapping] Mitogen-activated protein kinase
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MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)