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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.1
Chromosome location (bp)
43770184 - 43786487
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A2A2V4 [Direct mapping] Vascular endothelial growth factor A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
A0A0A0MR43 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
J3KPA4 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A0A0MRQ4 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
H3BLW8 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
A0A0A0MSI7 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A0A0MSH7 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
A0A0A0MSH5 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
A0A0A0MTB2 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
H0YBZ0 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
H0YBI8 [Direct mapping] Vascular endothelial growth factor A
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
P15692 [Direct mapping] Vascular endothelial growth factor A A0A024RD37 [Target identity:100%; Query identity:100%] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007165 [signal transduction] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
P15692 [Direct mapping] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
P15692 [Direct mapping] Vascular endothelial growth factor A A0A024RD33 [Target identity:100%; Query identity:100%] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007165 [signal transduction] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0042056 [chemoattractant activity] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin]
P15692 [Direct mapping] Vascular endothelial growth factor A A0A0Y0IMM4 [Target identity:100%; Query identity:100%] Vascular endothelial growth factor A
Show all
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001525 [angiogenesis] GO:0001541 [ovarian follicle development] GO:0001569 [branching involved in blood vessel morphogenesis] GO:0001570 [vasculogenesis] GO:0001666 [response to hypoxia] GO:0001701 [in utero embryonic development] GO:0001822 [kidney development] GO:0001934 [positive regulation of protein phosphorylation] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0001968 [fibronectin binding] GO:0002040 [sprouting angiogenesis] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002092 [positive regulation of receptor internalization] GO:0002575 [basophil chemotaxis] GO:0002576 [platelet degranulation] GO:0002687 [positive regulation of leukocyte migration] GO:0003007 [heart morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003169 [coronary vein morphogenesis] GO:0005125 [cytokine activity] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005172 [vascular endothelial growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005912 [adherens junction] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007165 [signal transduction] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0007498 [mesoderm development] GO:0007595 [lactation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell population proliferation] GO:0008360 [regulation of cell shape] GO:0009986 [cell surface] GO:0010595 [positive regulation of endothelial cell migration] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010749 [regulation of nitric oxide mediated signal transduction] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030141 [secretory granule] GO:0030154 [cell differentiation] GO:0030224 [monocyte differentiation] GO:0030225 [macrophage differentiation] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030855 [epithelial cell differentiation] GO:0031012 [extracellular matrix] GO:0031077 [post-embryonic camera-type eye development] GO:0031093 [platelet alpha granule lumen] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031954 [positive regulation of protein autophosphorylation] GO:0032147 [activation of protein kinase activity] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0035148 [tube formation] GO:0035767 [endothelial cell chemotaxis] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036303 [lymph vessel morphogenesis] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway] GO:0038084 [vascular endothelial growth factor signaling pathway] GO:0038089 [positive regulation of cell migration by vascular endothelial growth factor signaling pathway] GO:0038091 [positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway] GO:0038190 [VEGF-activated neuropilin signaling pathway] GO:0038191 [neuropilin binding] GO:0042056 [chemoattractant activity] GO:0042327 [positive regulation of phosphorylation] GO:0042462 [eye photoreceptor cell development] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043117 [positive regulation of vascular permeability] GO:0043129 [surfactant homeostasis] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043406 [positive regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043536 [positive regulation of blood vessel endothelial cell migration] GO:0045766 [positive regulation of angiogenesis] GO:0045785 [positive regulation of cell adhesion] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048018 [receptor ligand activity] GO:0048469 [cell maturation] GO:0048593 [camera-type eye morphogenesis] GO:0048739 [cardiac muscle fiber development] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048842 [positive regulation of axon extension involved in axon guidance] GO:0048844 [artery morphogenesis] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050840 [extracellular matrix binding] GO:0050918 [positive chemotaxis] GO:0050927 [positive regulation of positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051272 [positive regulation of cellular component movement] GO:0051781 [positive regulation of cell division] GO:0051894 [positive regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060319 [primitive erythrocyte differentiation] GO:0060749 [mammary gland alveolus development] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060948 [cardiac vascular smooth muscle cell development] GO:0060982 [coronary artery morphogenesis] GO:0061042 [vascular wound healing] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071456 [cellular response to hypoxia] GO:0071542 [dopaminergic neuron differentiation] GO:0071679 [commissural neuron axon guidance] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis] GO:0090190 [positive regulation of branching involved in ureteric bud morphogenesis] GO:0090259 [regulation of retinal ganglion cell axon guidance] GO:0097475 [motor neuron migration] GO:0097533 [cellular stress response to acid chemical] GO:0120162 [positive regulation of cold-induced thermogenesis] GO:1900086 [positive regulation of peptidyl-tyrosine autophosphorylation] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901165 [positive regulation of trophoblast cell migration] GO:1901727 [positive regulation of histone deacetylase activity] GO:1902336 [positive regulation of retinal ganglion cell axon guidance] GO:1902966 [positive regulation of protein localization to early endosome] GO:1903141 [negative regulation of establishment of endothelial barrier] GO:1903392 [negative regulation of adherens junction organization] GO:1903572 [positive regulation of protein kinase D signaling] GO:1903589 [positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1905278 [positive regulation of epithelial tube formation] GO:1905604 [negative regulation of blood-brain barrier permeability] GO:2000048 [negative regulation of cell-cell adhesion mediated by cadherin] GO:2000573 [positive regulation of DNA biosynthetic process]
A0A5F9ZH41 [Direct mapping] Vascular endothelial growth factor A
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MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Musculoskeletal diseases Skeletal diseases Nervous system diseases Eye disease Other nervous and sensory system diseases Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
