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WNT5A
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  • WNT5A
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

WNT5A
Synonyms hWNT5A
Gene descriptioni

Full gene name according to HGNC.

Wnt family member 5A
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 3
Cytoband p14.3
Chromosome location (bp) 55465715 - 55490539
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

4
Ensembl ENSG00000114251 (version 103.38)
Entrez gene 7474
HGNC HGNC:12784
UniProt P41221 (UniProt - Evidence at protein level)
neXtProt NX_P41221
Antibodypedia WNT5A antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 4      # Population variants: 221

Antigens:

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On

Variants:

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Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
WNT5A-201
WNT5A-202
WNT5A-203
WNT5A-205


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
WNT5A-201
ENSP00000264634
ENST00000264634
P41221 [Direct mapping]
Protein Wnt-5a
A0A384N611 [Target identity:100%; Query identity:100%]
Protein Wnt
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0002720 [positive regulation of cytokine production involved in immune response]
GO:0003408 [optic cup formation involved in camera-type eye development]
GO:0005102 [signaling receptor binding]
GO:0005109 [frizzled binding]
GO:0005115 [receptor tyrosine kinase-like orphan receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007257 [activation of JUN kinase activity]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0008584 [male gonad development]
GO:0010033 [response to organic substance]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0016055 [Wnt signaling pathway]
GO:0021891 [olfactory bulb interneuron development]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032148 [activation of protein kinase B activity]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034613 [cellular protein localization]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042060 [wound healing]
GO:0043032 [positive regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045165 [cell fate commitment]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045778 [positive regulation of ossification]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048018 [receptor ligand activity]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048706 [embryonic skeletal system development]
GO:0048806 [genitalia development]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0050807 [regulation of synapse organization]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051216 [cartilage development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060324 [face development]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0060760 [positive regulation of response to cytokine stimulus]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0061024 [membrane organization]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071346 [cellular response to interferon-gamma]
GO:0071425 [hematopoietic stem cell proliferation]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099054 [presynapse assembly]
GO:0099068 [postsynapse assembly]
GO:0099175 [regulation of postsynapse organization]
GO:0099566 [regulation of postsynaptic cytosolic calcium ion concentration]
GO:0150012 [positive regulation of neuron projection arborization]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1904861 [excitatory synapse assembly]
GO:1904862 [inhibitory synapse assembly]
GO:1904934 [negative regulation of cell proliferation in midbrain]
GO:1904953 [Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1904955 [planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation]
Show all
380 aa
42.3 kDa
Yes 0
WNT5A-202
ENSP00000417310
ENST00000474267
P41221 [Direct mapping]
Protein Wnt-5a
A0A384N611 [Target identity:100%; Query identity:100%]
Protein Wnt
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001667 [ameboidal-type cell migration]
GO:0001736 [establishment of planar polarity]
GO:0001756 [somitogenesis]
GO:0001819 [positive regulation of cytokine production]
GO:0001822 [kidney development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001843 [neural tube closure]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001947 [heart looping]
GO:0002009 [morphogenesis of an epithelium]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0002720 [positive regulation of cytokine production involved in immune response]
GO:0003138 [primary heart field specification]
GO:0003139 [secondary heart field specification]
GO:0003281 [ventricular septum development]
GO:0003283 [atrial septum development]
GO:0003323 [type B pancreatic cell development]
GO:0003344 [pericardium morphogenesis]
GO:0003401 [axis elongation]
GO:0003402 [planar cell polarity pathway involved in axis elongation]
GO:0003408 [optic cup formation involved in camera-type eye development]
GO:0005102 [signaling receptor binding]
GO:0005109 [frizzled binding]
GO:0005115 [receptor tyrosine kinase-like orphan receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0007275 [multicellular organism development]
GO:0007368 [determination of left/right symmetry]
GO:0007409 [axonogenesis]
GO:0007411 [axon guidance]
GO:0007442 [hindgut morphogenesis]
GO:0007494 [midgut development]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008584 [male gonad development]
GO:0008595 [anterior/posterior axis specification, embryo]
GO:0009952 [anterior/posterior pattern specification]
GO:0009986 [cell surface]
GO:0010033 [response to organic substance]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010800 [positive regulation of peptidyl-threonine phosphorylation]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0016055 [Wnt signaling pathway]
GO:0016477 [cell migration]
GO:0019904 [protein domain specific binding]
GO:0021891 [olfactory bulb interneuron development]
GO:0021915 [neural tube development]
GO:0022008 [neurogenesis]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030324 [lung development]
GO:0030326 [embryonic limb morphogenesis]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0030901 [midbrain development]
GO:0031012 [extracellular matrix]
GO:0032092 [positive regulation of protein binding]
GO:0032148 [activation of protein kinase B activity]
GO:0032722 [positive regulation of chemokine production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0032880 [regulation of protein localization]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034613 [cellular protein localization]
GO:0035108 [limb morphogenesis]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0036342 [post-anal tail morphogenesis]
GO:0036517 [chemoattraction of serotonergic neuron axon]
GO:0036518 [chemorepulsion of dopaminergic neuron axon]
GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0042060 [wound healing]
GO:0042472 [inner ear morphogenesis]
GO:0042733 [embryonic digit morphogenesis]
GO:0043032 [positive regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045165 [cell fate commitment]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045778 [positive regulation of ossification]
GO:0045807 [positive regulation of endocytosis]
GO:0045836 [positive regulation of meiotic nuclear division]
GO:0045860 [positive regulation of protein kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046546 [development of primary male sexual characteristics]
GO:0048018 [receptor ligand activity]
GO:0048022 [negative regulation of melanin biosynthetic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048341 [paraxial mesoderm formation]
GO:0048546 [digestive tract morphogenesis]
GO:0048570 [notochord morphogenesis]
GO:0048706 [embryonic skeletal system development]
GO:0048806 [genitalia development]
GO:0048812 [neuron projection morphogenesis]
GO:0048843 [negative regulation of axon extension involved in axon guidance]
GO:0048850 [hypophysis morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0050807 [regulation of synapse organization]
GO:0050919 [negative chemotaxis]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051216 [cartilage development]
GO:0051885 [positive regulation of timing of anagen]
GO:0051964 [negative regulation of synapse assembly]
GO:0060026 [convergent extension]
GO:0060028 [convergent extension involved in axis elongation]
GO:0060029 [convergent extension involved in organogenesis]
GO:0060065 [uterus development]
GO:0060067 [cervix development]
GO:0060068 [vagina development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060157 [urinary bladder development]
GO:0060324 [face development]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0060599 [lateral sprouting involved in mammary gland duct morphogenesis]
GO:0060606 [tube closure]
GO:0060638 [mesenchymal-epithelial cell signaling]
GO:0060686 [negative regulation of prostatic bud formation]
GO:0060744 [mammary gland branching involved in thelarche]
GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation]
GO:0060760 [positive regulation of response to cytokine stimulus]
GO:0060762 [regulation of branching involved in mammary gland duct morphogenesis]
GO:0060775 [planar cell polarity pathway involved in gastrula mediolateral intercalation]
GO:0060809 [mesodermal to mesenchymal transition involved in gastrulation]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0061024 [membrane organization]
GO:0061036 [positive regulation of cartilage development]
GO:0061053 [somite development]
GO:0061347 [planar cell polarity pathway involved in outflow tract morphogenesis]
GO:0061348 [planar cell polarity pathway involved in ventricular septum morphogenesis]
GO:0061349 [planar cell polarity pathway involved in cardiac right atrium morphogenesis]
GO:0061350 [planar cell polarity pathway involved in cardiac muscle tissue morphogenesis]
GO:0061354 [planar cell polarity pathway involved in pericardium morphogenesis]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071219 [cellular response to molecule of bacterial origin]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071346 [cellular response to interferon-gamma]
GO:0071425 [hematopoietic stem cell proliferation]
GO:0071542 [dopaminergic neuron differentiation]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
GO:0090009 [primitive streak formation]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090082 [positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090103 [cochlea morphogenesis]
GO:0090179 [planar cell polarity pathway involved in neural tube closure]
GO:0090630 [activation of GTPase activity]
GO:0097325 [melanocyte proliferation]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099054 [presynapse assembly]
GO:0099068 [postsynapse assembly]
GO:0099175 [regulation of postsynapse organization]
GO:0099566 [regulation of postsynaptic cytosolic calcium ion concentration]
GO:0150012 [positive regulation of neuron projection arborization]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901216 [positive regulation of neuron death]
GO:1902379 [chemoattractant activity involved in axon guidance]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1903827 [regulation of cellular protein localization]
GO:1904861 [excitatory synapse assembly]
GO:1904862 [inhibitory synapse assembly]
GO:1904934 [negative regulation of cell proliferation in midbrain]
GO:1904938 [planar cell polarity pathway involved in axon guidance]
GO:1904948 [midbrain dopaminergic neuron differentiation]
GO:1904953 [Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1904955 [planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
GO:2000052 [positive regulation of non-canonical Wnt signaling pathway]
Show all
380 aa
42.3 kDa
Yes 0
WNT5A-203
ENSP00000418184
ENST00000482079
C9J8I8 [Direct mapping]
Protein Wnt
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [signaling receptor binding]
GO:0005576 [extracellular region]
GO:0007275 [multicellular organism development]
GO:0016055 [Wnt signaling pathway]
Show all
214 aa
24 kDa
Yes 0
WNT5A-205
ENSP00000420104
ENST00000497027
P41221 [Direct mapping]
Protein Wnt-5a
A0A024R316 [Target identity:100%; Query identity:100%]
Protein Wnt
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002088 [lens development in camera-type eye]
GO:0002720 [positive regulation of cytokine production involved in immune response]
GO:0003408 [optic cup formation involved in camera-type eye development]
GO:0005102 [signaling receptor binding]
GO:0005109 [frizzled binding]
GO:0005115 [receptor tyrosine kinase-like orphan receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005796 [Golgi lumen]
GO:0005886 [plasma membrane]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0007257 [activation of JUN kinase activity]
GO:0007275 [multicellular organism development]
GO:0007411 [axon guidance]
GO:0008584 [male gonad development]
GO:0010033 [response to organic substance]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010628 [positive regulation of gene expression]
GO:0010820 [positive regulation of T cell chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0016055 [Wnt signaling pathway]
GO:0021891 [olfactory bulb interneuron development]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032148 [activation of protein kinase B activity]
GO:0032722 [positive regulation of chemokine production]
GO:0032731 [positive regulation of interleukin-1 beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0034613 [cellular protein localization]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0042060 [wound healing]
GO:0043032 [positive regulation of macrophage activation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045165 [cell fate commitment]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045778 [positive regulation of ossification]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0048018 [receptor ligand activity]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048706 [embryonic skeletal system development]
GO:0048806 [genitalia development]
GO:0050727 [regulation of inflammatory response]
GO:0050729 [positive regulation of inflammatory response]
GO:0050807 [regulation of synapse organization]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051216 [cartilage development]
GO:0060070 [canonical Wnt signaling pathway]
GO:0060071 [Wnt signaling pathway, planar cell polarity pathway]
GO:0060324 [face development]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0060760 [positive regulation of response to cytokine stimulus]
GO:0060907 [positive regulation of macrophage cytokine production]
GO:0061024 [membrane organization]
GO:0062009 [secondary palate development]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071277 [cellular response to calcium ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071346 [cellular response to interferon-gamma]
GO:0071425 [hematopoietic stem cell proliferation]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
GO:0090037 [positive regulation of protein kinase C signaling]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:0099054 [presynapse assembly]
GO:0099068 [postsynapse assembly]
GO:0099175 [regulation of postsynapse organization]
GO:0099566 [regulation of postsynaptic cytosolic calcium ion concentration]
GO:0150012 [positive regulation of neuron projection arborization]
GO:1900020 [positive regulation of protein kinase C activity]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1904861 [excitatory synapse assembly]
GO:1904862 [inhibitory synapse assembly]
GO:1904934 [negative regulation of cell proliferation in midbrain]
GO:1904953 [Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation]
GO:1904955 [planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation]
Show all
365 aa
40.9 kDa
Yes 0

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