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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q29
Chromosome location (bp)
194136148 - 194138732
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
HES1-201
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Basic domains Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001217 [DNA-binding transcription repressor activity] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0003143 [embryonic heart tube morphogenesis] GO:0003151 [outflow tract morphogenesis] GO:0003266 [regulation of secondary heart field cardioblast proliferation] GO:0003281 [ventricular septum development] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0007155 [cell adhesion] GO:0007219 [Notch signaling pathway] GO:0007224 [smoothened signaling pathway] GO:0007389 [pattern specification process] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0009952 [anterior/posterior pattern specification] GO:0016477 [cell migration] GO:0021537 [telencephalon development] GO:0021555 [midbrain-hindbrain boundary morphogenesis] GO:0021557 [oculomotor nerve development] GO:0021558 [trochlear nerve development] GO:0021575 [hindbrain morphogenesis] GO:0021861 [forebrain radial glial cell differentiation] GO:0021915 [neural tube development] GO:0021983 [pituitary gland development] GO:0021984 [adenohypophysis development] GO:0030324 [lung development] GO:0030513 [positive regulation of BMP signaling pathway] GO:0030901 [midbrain development] GO:0031016 [pancreas development] GO:0032991 [protein-containing complex] GO:0035019 [somatic stem cell population maintenance] GO:0035909 [aorta morphogenesis] GO:0035910 [ascending aorta morphogenesis] GO:0042102 [positive regulation of T cell proliferation] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043388 [positive regulation of DNA binding] GO:0043398 [HLH domain binding] GO:0043433 [negative regulation of DNA-binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0045165 [cell fate commitment] GO:0045596 [negative regulation of cell differentiation] GO:0045598 [regulation of fat cell differentiation] GO:0045608 [negative regulation of inner ear auditory receptor cell differentiation] GO:0045665 [negative regulation of neuron differentiation] GO:0045747 [positive regulation of Notch signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0045977 [positive regulation of mitotic cell cycle, embryonic] GO:0046331 [lateral inhibition] GO:0046425 [regulation of receptor signaling pathway via JAK-STAT] GO:0046427 [positive regulation of receptor signaling pathway via JAK-STAT] GO:0046983 [protein dimerization activity] GO:0048469 [cell maturation] GO:0048505 [regulation of timing of cell differentiation] GO:0048538 [thymus development] GO:0048667 [cell morphogenesis involved in neuron differentiation] GO:0048711 [positive regulation of astrocyte differentiation] GO:0048715 [negative regulation of oligodendrocyte differentiation] GO:0048844 [artery morphogenesis] GO:0050678 [regulation of epithelial cell proliferation] GO:0050767 [regulation of neurogenesis] GO:0051087 [chaperone binding] GO:0060122 [inner ear receptor cell stereocilium organization] GO:0060164 [regulation of timing of neuron differentiation] GO:0060253 [negative regulation of glial cell proliferation] GO:0060412 [ventricular septum morphogenesis] GO:0060675 [ureteric bud morphogenesis] GO:0060716 [labyrinthine layer blood vessel development] GO:0061009 [common bile duct development] GO:0061106 [negative regulation of stomach neuroendocrine cell differentiation] GO:0061309 [cardiac neural crest cell development involved in outflow tract morphogenesis] GO:0061626 [pharyngeal arch artery morphogenesis] GO:0065003 [protein-containing complex assembly] GO:0070888 [E-box binding] GO:0071820 [N-box binding] GO:0072012 [glomerulus vasculature development] GO:0072049 [comma-shaped body morphogenesis] GO:0072050 [S-shaped body morphogenesis] GO:0072141 [renal interstitial fibroblast development] GO:0072282 [metanephric nephron tubule morphogenesis] GO:0090102 [cochlea development] GO:0090162 [establishment of epithelial cell polarity] GO:0097084 [vascular associated smooth muscle cell development] GO:0097150 [neuronal stem cell population maintenance] GO:1905934 [negative regulation of cell fate determination] GO:1990837 [sequence-specific double-stranded DNA binding] GO:2000227 [negative regulation of pancreatic A cell differentiation] GO:2000737 [negative regulation of stem cell differentiation] GO:2000974 [negative regulation of pro-B cell differentiation] GO:2000978 [negative regulation of forebrain neuron differentiation] GO:2000981 [negative regulation of inner ear receptor cell differentiation]