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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Disease related genes Human disease related genes Plasma proteins Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q32.2
Chromosome location (bp)
190908460 - 191020960
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0007259 [receptor signaling pathway via JAK-STAT] GO:0008015 [blood circulation] GO:0010742 [macrophage derived foam cell differentiation] GO:0016032 [viral process] GO:0016525 [negative regulation of angiogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032727 [positive regulation of interferon-alpha production] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034097 [response to cytokine] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0035456 [response to interferon-beta] GO:0035458 [cellular response to interferon-beta] GO:0038113 [interleukin-9-mediated signaling pathway] GO:0038114 [interleukin-21-mediated signaling pathway] GO:0042127 [regulation of cell population proliferation] GO:0042393 [histone binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434 [response to peptide hormone] GO:0044389 [ubiquitin-like protein ligase binding] GO:0045296 [cadherin binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0061326 [renal tubule development] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0070106 [interleukin-27-mediated signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070757 [interleukin-35-mediated signaling pathway] GO:0071346 [cellular response to interferon-gamma] GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162 [metanephric mesenchymal cell differentiation] GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:1990841 [promoter-specific chromatin binding]
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0007259 [receptor signaling pathway via JAK-STAT] GO:0008015 [blood circulation] GO:0010742 [macrophage derived foam cell differentiation] GO:0016032 [viral process] GO:0016525 [negative regulation of angiogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032727 [positive regulation of interferon-alpha production] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034097 [response to cytokine] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0035456 [response to interferon-beta] GO:0035458 [cellular response to interferon-beta] GO:0038113 [interleukin-9-mediated signaling pathway] GO:0038114 [interleukin-21-mediated signaling pathway] GO:0042127 [regulation of cell population proliferation] GO:0042393 [histone binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434 [response to peptide hormone] GO:0044389 [ubiquitin-like protein ligase binding] GO:0045296 [cadherin binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0061326 [renal tubule development] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0070106 [interleukin-27-mediated signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070757 [interleukin-35-mediated signaling pathway] GO:0071346 [cellular response to interferon-gamma] GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162 [metanephric mesenchymal cell differentiation] GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:1990841 [promoter-specific chromatin binding]
J3KPM9 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0007259 [receptor signaling pathway via JAK-STAT] GO:0008015 [blood circulation] GO:0010742 [macrophage derived foam cell differentiation] GO:0016032 [viral process] GO:0016525 [negative regulation of angiogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032727 [positive regulation of interferon-alpha production] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034097 [response to cytokine] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0035456 [response to interferon-beta] GO:0035458 [cellular response to interferon-beta] GO:0038113 [interleukin-9-mediated signaling pathway] GO:0038114 [interleukin-21-mediated signaling pathway] GO:0042127 [regulation of cell population proliferation] GO:0042393 [histone binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434 [response to peptide hormone] GO:0044389 [ubiquitin-like protein ligase binding] GO:0045296 [cadherin binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0061326 [renal tubule development] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0070106 [interleukin-27-mediated signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070757 [interleukin-35-mediated signaling pathway] GO:0071346 [cellular response to interferon-gamma] GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162 [metanephric mesenchymal cell differentiation] GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:1990841 [promoter-specific chromatin binding]
E7EPD2 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
E9PH66 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
E7ENM1 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0007259 [receptor signaling pathway via JAK-STAT] GO:0008015 [blood circulation] GO:0010742 [macrophage derived foam cell differentiation] GO:0016032 [viral process] GO:0016525 [negative regulation of angiogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032727 [positive regulation of interferon-alpha production] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034097 [response to cytokine] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0035456 [response to interferon-beta] GO:0035458 [cellular response to interferon-beta] GO:0038113 [interleukin-9-mediated signaling pathway] GO:0038114 [interleukin-21-mediated signaling pathway] GO:0042127 [regulation of cell population proliferation] GO:0042393 [histone binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434 [response to peptide hormone] GO:0044389 [ubiquitin-like protein ligase binding] GO:0045296 [cadherin binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0061326 [renal tubule development] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0070106 [interleukin-27-mediated signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070757 [interleukin-35-mediated signaling pathway] GO:0071346 [cellular response to interferon-gamma] GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162 [metanephric mesenchymal cell differentiation] GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:1990841 [promoter-specific chromatin binding]
A0A669KB68 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
A0A669KB56 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
P42224 [Direct mapping] Signal transducer and activator of transcription 1-alpha/beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Immunoglobulin fold Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001937 [negative regulation of endothelial cell proliferation] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002230 [positive regulation of defense response to virus by host] GO:0003340 [negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006952 [defense response] GO:0007165 [signal transduction] GO:0007221 [positive regulation of transcription of Notch receptor target] GO:0007259 [receptor signaling pathway via JAK-STAT] GO:0008015 [blood circulation] GO:0010742 [macrophage derived foam cell differentiation] GO:0016032 [viral process] GO:0016525 [negative regulation of angiogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0019899 [enzyme binding] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032727 [positive regulation of interferon-alpha production] GO:0032991 [protein-containing complex] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0034097 [response to cytokine] GO:0035035 [histone acetyltransferase binding] GO:0035257 [nuclear hormone receptor binding] GO:0035456 [response to interferon-beta] GO:0035458 [cellular response to interferon-beta] GO:0038113 [interleukin-9-mediated signaling pathway] GO:0038114 [interleukin-21-mediated signaling pathway] GO:0042127 [regulation of cell population proliferation] GO:0042393 [histone binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043434 [response to peptide hormone] GO:0044389 [ubiquitin-like protein ligase binding] GO:0045296 [cadherin binding] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046725 [negative regulation by virus of viral protein levels in host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051591 [response to cAMP] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0061326 [renal tubule development] GO:0070102 [interleukin-6-mediated signaling pathway] GO:0070106 [interleukin-27-mediated signaling pathway] GO:0070491 [repressing transcription factor binding] GO:0070757 [interleukin-35-mediated signaling pathway] GO:0071346 [cellular response to interferon-gamma] GO:0072136 [metanephric mesenchymal cell proliferation involved in metanephros development] GO:0072162 [metanephric mesenchymal cell differentiation] GO:0072308 [negative regulation of metanephric nephron tubule epithelial cell differentiation] GO:1990841 [promoter-specific chromatin binding]
A0A669KBA4 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
A0A669KB68 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
A0A669KB53 [Direct mapping] Signal transducer and activator of transcription
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Other immune system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0007259 [receptor signaling pathway via JAK-STAT] GO:0007584 [response to nutrient] GO:0008015 [blood circulation] GO:0008284 [positive regulation of cell population proliferation] GO:0009612 [response to mechanical stimulus] GO:0014070 [response to organic cyclic compound] GO:0030424 [axon] GO:0030425 [dendrite] GO:0031730 [CCR5 chemokine receptor binding] GO:0032869 [cellular response to insulin stimulus] GO:0034097 [response to cytokine] GO:0042493 [response to drug] GO:0042542 [response to hydrogen peroxide] GO:0043434 [response to peptide hormone] GO:0043565 [sequence-specific DNA binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0051591 [response to cAMP] GO:0051721 [protein phosphatase 2A binding] GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process] GO:0071345 [cellular response to cytokine stimulus] GO:0071407 [cellular response to organic cyclic compound]
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