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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:26.4 nTPM
HPA:26.4 nTPM
GTEx:13.1 nTPM
FANTOM5:11.0 Scaled Tags Per Million
Pig:77.9 nTPM
Mouse:57.2 nTPM
Allen mouse:0.7 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 26.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 23.4
2586 Male, age 75, left hemisphere 29.0
1827 Male, age 72, unknown 24.7
2019 Male, age 18, unknown 24.7
2828 Female, age 72, unknown 23.9
2411 Female, age 72, unknown 22.8
1833 Male, age 53, unknown 22.2
1870 Female, age 42, unknown 22.0
2666 Male, age 74, left hemisphere 21.8
2219 Male, age 76, both hemispheres 21.6
1830 Male, age 51, unknown 20.9
Dorsal raphe nucleus
nTPM: 20.5
1828 Male, age 53, unknown 21.3
2298 Female, age 72, unknown 20.7
2750 Male, age 76, both hemispheres 20.5
2016 Female, age 72, unknown 20.1
2047 Male, age 72, unknown 19.7
Inferior colliculus
nTPM: 23.7
2097 Female, age 72, unknown 26.3
1890 Male, age 53, unknown 23.8
1848 Female, age 42, unknown 23.0
2849 Male, age 72, unknown 21.6
Median raphe nucleus
nTPM: 19.7
2220 Male, age 76, midline 19.7
Pedunculopontine tegmental nucleus
nTPM: 21.5
1921 Female, age 85, both hemispheres 25.2
2334 Male, age 80, both hemispheres 20.8
2338 Male, age 61, both hemispheres 18.4
Periaquaductal grey, anterior
nTPM: 23.9
1795 Male, age 51, unknown 25.0
2502 Female, age 75, unknown 23.9
1947 Male, age 18, unknown 23.0
Periaquaductal grey, dorsal
nTPM: 22.2
1831 Male, age 72, unknown 24.2
1840 Male, age 53, unknown 22.9
2464 Female, age 72, unknown 21.9
2850 Male, age 76, both hemispheres 19.9
Periaquaductal grey, lateral
nTPM: 21.6
2053 Male, age 18, unknown 23.7
2140 Male, age 76, both hemispheres 20.6
2272 Male, age 74, both hemispheres 20.6
Pretectal area
nTPM: 26.4
2007 Male, age 72, unknown 32.7
1816 Male, age 51, unknown 32.6
1817 Female, age 42, unknown 30.5
1944 Female, age 72, unknown 30.2
1815 Male, age 53, unknown 28.4
2407 Male, age 75, both hemispheres 25.5
2667 Female, age 75, unknown 24.7
2273 Male, age 74, both hemispheres 22.9
2825 Male, age 18, unknown 21.2
2316 Male, age 76, right hemisphere 20.8
2224 Female, age 72, unknown 20.3
Red nucleus
nTPM: 22.9
2785 Male, age 18, unknown 24.6
1821 Female, age 72, unknown 23.8
2588 Male, age 74, left hemisphere 23.4
2725 Female, age 75, unknown 23.4
1904 Male, age 53, unknown 23.2
2503 Female, age 72, unknown 23.0
2584 Male, age 75, left hemisphere 23.0
2823 Male, age 76, right hemisphere 22.9
1865 Male, age 51, unknown 22.3
1954 Female, age 42, unknown 22.2
2227 Male, age 72, unknown 21.6
2769 Male, age 72, unknown 21.5
Substantia nigra
nTPM: 22.5
1889 Female, age 72, unknown 29.0
2583 Male, age 75, right hemisphere 24.9
2590 Female, age 75, unknown 22.7
2409 Female, age 72, unknown 22.6
2665 Male, age 74, both hemispheres 22.0
1851 Male, age 51, unknown 21.9
1916 Female, age 42, unknown 21.7
1941 Male, age 53, unknown 20.8
2241 Male, age 72, unknown 20.2
2699 Male, age 18, unknown 19.4
Superior colliculus
nTPM: 24.9
2261 Male, age 18, unknown 29.3
2087 Female, age 72, unknown 27.7
2664 Male, age 75, both hemispheres 26.6
1995 Male, age 72, unknown 24.8
2668 Female, age 75, unknown 24.7
1796 Male, age 53, unknown 24.4
1895 Male, age 76, right hemisphere 24.1
1913 Female, age 42, unknown 24.0
1839 Male, age 51, unknown 22.5
2587 Male, age 74, left hemisphere 21.2
Ventral tegmental area
nTPM: 21.2
2410 Female, age 72, unknown 23.1
2218 Male, age 76, both hemispheres 21.7
1942 Male, age 51, unknown 21.2
2223 Female, age 72, unknown 21.0
1915 Female, age 42, unknown 20.4
2021 Male, age 53, unknown 20.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 13.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 13.1
Samples: 139

Max nTPM: 24.3
Min nTPM: 7.6
Std nTPM: 2.5
Median nTPM: 12.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 24.3
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 20.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 19.3
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 18.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 18.0
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 18.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 17.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 17.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 17.1
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 16.9
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 16.7
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 16.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 16.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 16.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 16.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 16.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 16.0
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 15.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 15.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 15.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 15.7
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 15.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 15.2
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 15.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 15.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 15.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 15.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 15.1
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 15.0
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 14.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 14.9
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 14.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 14.8
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 14.7
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 14.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 14.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 14.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 14.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 14.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 14.4
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 14.4
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 14.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 14.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 14.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 14.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 14.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 14.0
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 13.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 13.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 13.8
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 13.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 13.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 13.7
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 13.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 13.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 13.6
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 13.5
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 13.5
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 13.4
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 13.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 13.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 13.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 13.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 13.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 13.2
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 13.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 13.1
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 13.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 13.1
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 12.9
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 12.9
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 12.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 12.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 12.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 12.8
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 12.8
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 12.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 12.6
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 12.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 12.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 12.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 12.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 12.4
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 12.4
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 12.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 12.2
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 12.2
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 12.2
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 12.1
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 12.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 12.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 12.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 12.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 12.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 12.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 12.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 12.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 11.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 11.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 11.7
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 11.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 11.6
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 11.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 11.5
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 11.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 11.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 11.3
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 11.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 11.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 11.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 11.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 11.0
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 11.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 10.9
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 10.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 10.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 10.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 10.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 10.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 10.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 10.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 10.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 10.3
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 10.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 10.1
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 10.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 9.8
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 9.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 9.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 9.5
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 9.5
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 9.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 9.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 9.0
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 8.9
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 8.7
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 7.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 7.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 7.6
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 11.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 11.0
FF:10158-103A5 76 years, female 11.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 77.9
Pig sample Sample description nTPM
Midbrain
nTPM: 78.0
Samples: 4

Max nTPM: 133.8
Min nTPM: 53.8
Sample A Female 133.8
Sample B Female 68.9
Sample C Male 55.3
Sample D Male 53.8
Periaqueductal gray
nTPM: 48.8
Samples: 3

Max nTPM: 55.7
Min nTPM: 45.1
Sample B Female 55.7
Sample C Male 45.1
Sample D Male 45.5
Substantia nigra
nTPM: 67.1
Samples: 4

Max nTPM: 81.0
Min nTPM: 42.4
Sample A Female 79.9
Sample B Female 42.4
Sample C Male 65.0
Sample D Male 81.0
Superior colliculi
nTPM: 60.1
Samples: 4

Max nTPM: 74.7
Min nTPM: 35.3
Sample A Female 74.7
Sample B Female 35.3
Sample C Male 61.2
Sample D Male 69.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 57.2
Mouse sample Sample description nTPM
Midbrain
nTPM: 57.2
Samples: 4

Max nTPM: 58.6
Min nTPM: 55.1
Sample A Male 57.5
Sample B Male 57.7
Sample C Female 55.1
Sample D Female 58.6

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.7
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.7
74657931 Antisense, RP_060220_02_F10, Mouse strain C57BL/6J (56 days, male) 1.1
68919018 Antisense, RP_050301_02_D06, Mouse strain C57BL/6J (56 days, male) 0.2

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