We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.23
Chromosome location (bp)
7954291 - 7985505
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PARK7-201
PARK7-202
PARK7-203
PARK7-204
PARK7-207
PARK7-208
PARK7-209
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0001963 [synaptic transmission, dopaminergic] GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005102 [signaling receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0005759 [mitochondrial matrix] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006281 [DNA repair] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0008344 [adult locomotory behavior] GO:0009438 [methylglyoxal metabolic process] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016570 [histone modification] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0016787 [hydrolase activity] GO:0019249 [lactate biosynthetic process] GO:0019826 [oxygen sensor activity] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030073 [insulin secretion] GO:0030424 [axon] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033182 [regulation of histone ubiquitination] GO:0033234 [negative regulation of protein sumoylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034599 [cellular response to oxidative stress] GO:0034614 [cellular response to reactive oxygen species] GO:0035065 [regulation of histone acetylation] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0036524 [protein deglycase activity] GO:0036526 [peptidyl-cysteine deglycation] GO:0036527 [peptidyl-arginine deglycation] GO:0036528 [peptidyl-lysine deglycation] GO:0036529 [protein deglycation, glyoxal removal] GO:0036530 [protein deglycation, methylglyoxal removal] GO:0036531 [glutathione deglycation] GO:0042177 [negative regulation of protein catabolic process] GO:0042542 [response to hydrogen peroxide] GO:0042593 [glucose homeostasis] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043005 [neuron projection] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044297 [cell body] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0045296 [cadherin binding] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0048471 [perinuclear region of cytoplasm] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051583 [dopamine uptake involved in synaptic transmission] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0051899 [membrane depolarization] GO:0051920 [peroxiredoxin activity] GO:0060081 [membrane hyperpolarization] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061727 [methylglyoxal catabolic process to lactate] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0070994 [detection of oxidative stress] GO:0097110 [scaffold protein binding] GO:0098793 [presynapse] GO:0098869 [cellular oxidant detoxification] GO:0106044 [guanine deglycation] GO:0106045 [guanine deglycation, methylglyoxal removal] GO:0106046 [guanine deglycation, glyoxal removal] GO:0110095 [cellular detoxification of aldehyde] GO:0140041 [cellular detoxification of methylglyoxal] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902177 [positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of supramolecular fiber organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903189 [glyoxal metabolic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903204 [negative regulation of oxidative stress-induced neuron death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903428 [positive regulation of reactive oxygen species biosynthetic process] GO:1903599 [positive regulation of autophagy of mitochondrion] GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000277 [positive regulation of oxidative phosphorylation uncoupler activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005102 [signaling receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006281 [DNA repair] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0009438 [methylglyoxal metabolic process] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016570 [histone modification] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0016787 [hydrolase activity] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030073 [insulin secretion] GO:0030424 [axon] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033182 [regulation of histone ubiquitination] GO:0033234 [negative regulation of protein sumoylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034599 [cellular response to oxidative stress] GO:0035065 [regulation of histone acetylation] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0036524 [protein deglycase activity] GO:0036526 [peptidyl-cysteine deglycation] GO:0036527 [peptidyl-arginine deglycation] GO:0036528 [peptidyl-lysine deglycation] GO:0036529 [protein deglycation, glyoxal removal] GO:0036530 [protein deglycation, methylglyoxal removal] GO:0036531 [glutathione deglycation] GO:0042593 [glucose homeostasis] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0045296 [cadherin binding] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0048471 [perinuclear region of cytoplasm] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061727 [methylglyoxal catabolic process to lactate] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0097110 [scaffold protein binding] GO:0098793 [presynapse] GO:0098869 [cellular oxidant detoxification] GO:0106044 [guanine deglycation] GO:0106045 [guanine deglycation, methylglyoxal removal] GO:0106046 [guanine deglycation, glyoxal removal] GO:0110095 [cellular detoxification of aldehyde] GO:0140041 [cellular detoxification of methylglyoxal] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of supramolecular fiber organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903189 [glyoxal metabolic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903599 [positive regulation of autophagy of mitochondrion] GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005102 [signaling receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006281 [DNA repair] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0009438 [methylglyoxal metabolic process] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016570 [histone modification] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0016787 [hydrolase activity] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030073 [insulin secretion] GO:0030424 [axon] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033182 [regulation of histone ubiquitination] GO:0033234 [negative regulation of protein sumoylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034599 [cellular response to oxidative stress] GO:0035065 [regulation of histone acetylation] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0036524 [protein deglycase activity] GO:0036526 [peptidyl-cysteine deglycation] GO:0036527 [peptidyl-arginine deglycation] GO:0036528 [peptidyl-lysine deglycation] GO:0036529 [protein deglycation, glyoxal removal] GO:0036530 [protein deglycation, methylglyoxal removal] GO:0036531 [glutathione deglycation] GO:0042593 [glucose homeostasis] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0045296 [cadherin binding] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0048471 [perinuclear region of cytoplasm] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061727 [methylglyoxal catabolic process to lactate] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0097110 [scaffold protein binding] GO:0098793 [presynapse] GO:0098869 [cellular oxidant detoxification] GO:0106044 [guanine deglycation] GO:0106045 [guanine deglycation, methylglyoxal removal] GO:0106046 [guanine deglycation, glyoxal removal] GO:0110095 [cellular detoxification of aldehyde] GO:0140041 [cellular detoxification of methylglyoxal] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of supramolecular fiber organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903189 [glyoxal metabolic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903599 [positive regulation of autophagy of mitochondrion] GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
K7ELW0 [Direct mapping] Parkinson disease protein 7
Show all
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Neurodegenerative diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005102 [signaling receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006281 [DNA repair] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0009438 [methylglyoxal metabolic process] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016570 [histone modification] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0016787 [hydrolase activity] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030073 [insulin secretion] GO:0030424 [axon] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033182 [regulation of histone ubiquitination] GO:0033234 [negative regulation of protein sumoylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034599 [cellular response to oxidative stress] GO:0035065 [regulation of histone acetylation] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0036524 [protein deglycase activity] GO:0036526 [peptidyl-cysteine deglycation] GO:0036527 [peptidyl-arginine deglycation] GO:0036528 [peptidyl-lysine deglycation] GO:0036529 [protein deglycation, glyoxal removal] GO:0036530 [protein deglycation, methylglyoxal removal] GO:0036531 [glutathione deglycation] GO:0042593 [glucose homeostasis] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0045296 [cadherin binding] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0048471 [perinuclear region of cytoplasm] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061727 [methylglyoxal catabolic process to lactate] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0097110 [scaffold protein binding] GO:0098793 [presynapse] GO:0098869 [cellular oxidant detoxification] GO:0106044 [guanine deglycation] GO:0106045 [guanine deglycation, methylglyoxal removal] GO:0106046 [guanine deglycation, glyoxal removal] GO:0110095 [cellular detoxification of aldehyde] GO:0140041 [cellular detoxification of methylglyoxal] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of supramolecular fiber organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903189 [glyoxal metabolic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903599 [positive regulation of autophagy of mitochondrion] GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin] GO:0001933 [negative regulation of protein phosphorylation] GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus] GO:0003713 [transcription coactivator activity] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005102 [signaling receptor binding] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005912 [adherens junction] GO:0006281 [DNA repair] GO:0006469 [negative regulation of protein kinase activity] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0006914 [autophagy] GO:0006954 [inflammatory response] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007265 [Ras protein signal transduction] GO:0007338 [single fertilization] GO:0008134 [transcription factor binding] GO:0008233 [peptidase activity] GO:0009438 [methylglyoxal metabolic process] GO:0010273 [detoxification of copper ion] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0016532 [superoxide dismutase copper chaperone activity] GO:0016570 [histone modification] GO:0016605 [PML body] GO:0016684 [oxidoreductase activity, acting on peroxide as acceptor] GO:0016787 [hydrolase activity] GO:0019249 [lactate biosynthetic process] GO:0019899 [enzyme binding] GO:0019900 [kinase binding] GO:0019955 [cytokine binding] GO:0030073 [insulin secretion] GO:0030424 [axon] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031397 [negative regulation of protein ubiquitination] GO:0032091 [negative regulation of protein binding] GO:0032148 [activation of protein kinase B activity] GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032757 [positive regulation of interleukin-8 production] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0033182 [regulation of histone ubiquitination] GO:0033234 [negative regulation of protein sumoylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0034599 [cellular response to oxidative stress] GO:0035065 [regulation of histone acetylation] GO:0036470 [tyrosine 3-monooxygenase activator activity] GO:0036471 [cellular response to glyoxal] GO:0036478 [L-dopa decarboxylase activator activity] GO:0036524 [protein deglycase activity] GO:0036526 [peptidyl-cysteine deglycation] GO:0036527 [peptidyl-arginine deglycation] GO:0036528 [peptidyl-lysine deglycation] GO:0036529 [protein deglycation, glyoxal removal] GO:0036530 [protein deglycation, methylglyoxal removal] GO:0036531 [glutathione deglycation] GO:0042593 [glucose homeostasis] GO:0042743 [hydrogen peroxide metabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043523 [regulation of neuron apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0044388 [small protein activating enzyme binding] GO:0044390 [ubiquitin-like protein conjugating enzyme binding] GO:0044877 [protein-containing complex binding] GO:0045121 [membrane raft] GO:0045202 [synapse] GO:0045296 [cadherin binding] GO:0045340 [mercury ion binding] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046295 [glycolate biosynthetic process] GO:0046826 [negative regulation of protein export from nucleus] GO:0048471 [perinuclear region of cytoplasm] GO:0050681 [androgen receptor binding] GO:0050727 [regulation of inflammatory response] GO:0050787 [detoxification of mercury ion] GO:0050821 [protein stabilization] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051444 [negative regulation of ubiquitin-protein transferase activity] GO:0051881 [regulation of mitochondrial membrane potential] GO:0051897 [positive regulation of protein kinase B signaling] GO:0060548 [negative regulation of cell death] GO:0060765 [regulation of androgen receptor signaling pathway] GO:0061727 [methylglyoxal catabolic process to lactate] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070491 [repressing transcription factor binding] GO:0097110 [scaffold protein binding] GO:0098793 [presynapse] GO:0098869 [cellular oxidant detoxification] GO:0106044 [guanine deglycation] GO:0106045 [guanine deglycation, methylglyoxal removal] GO:0106046 [guanine deglycation, glyoxal removal] GO:0110095 [cellular detoxification of aldehyde] GO:0140041 [cellular detoxification of methylglyoxal] GO:1900182 [positive regulation of protein localization to nucleus] GO:1901215 [negative regulation of neuron death] GO:1901671 [positive regulation of superoxide dismutase activity] GO:1901984 [negative regulation of protein acetylation] GO:1902236 [negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1902903 [regulation of supramolecular fiber organization] GO:1902958 [positive regulation of mitochondrial electron transport, NADH to ubiquinone] GO:1903073 [negative regulation of death-inducing signaling complex assembly] GO:1903094 [negative regulation of protein K48-linked deubiquitination] GO:1903122 [negative regulation of TRAIL-activated apoptotic signaling pathway] GO:1903135 [cupric ion binding] GO:1903136 [cuprous ion binding] GO:1903168 [positive regulation of pyrroline-5-carboxylate reductase activity] GO:1903178 [positive regulation of tyrosine 3-monooxygenase activity] GO:1903181 [positive regulation of dopamine biosynthetic process] GO:1903189 [glyoxal metabolic process] GO:1903190 [glyoxal catabolic process] GO:1903197 [positive regulation of L-dopa biosynthetic process] GO:1903200 [positive regulation of L-dopa decarboxylase activity] GO:1903202 [negative regulation of oxidative stress-induced cell death] GO:1903206 [negative regulation of hydrogen peroxide-induced cell death] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903377 [negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway] GO:1903384 [negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway] GO:1903427 [negative regulation of reactive oxygen species biosynthetic process] GO:1903599 [positive regulation of autophagy of mitochondrion] GO:1905259 [negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway] GO:1990381 [ubiquitin-specific protease binding] GO:1990422 [glyoxalase (glycolic acid-forming) activity] GO:2000157 [negative regulation of ubiquitin-specific protease activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding] GO:2000825 [positive regulation of androgen receptor activity] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway]