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APOA1
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  • APOA1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

APOA1
Synonyms
Gene descriptioni

Full gene name according to HGNC.

Apolipoprotein A1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Human disease related genes
Metabolic proteins
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 11
Cytoband q23.3
Chromosome location (bp) 116835751 - 116837622
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

5
Ensembl ENSG00000118137 (version 103.38)
Entrez gene 335
HGNC HGNC:600
UniProt P02647 (UniProt - Evidence at protein level)
neXtProt NX_P02647
Antibodypedia APOA1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 22      # Population variants: 177

Experimental


Description: Solution structure of double super helix model (X-ray)

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
APOA1-201
APOA1-202
APOA1-203
APOA1-204
APOA1-205


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
APOA1-201
ENSP00000236850
ENST00000236850
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a; Epididymis secretory sperm binding protein
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Vascular diseases
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [amyloid-beta binding]
GO:0002576 [platelet degranulation]
GO:0002719 [negative regulation of cytokine production involved in immune response]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031072 [heat shock protein binding]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034371 [chylomicron remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034378 [chylomicron assembly]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0043691 [reverse cholesterol transport]
GO:0044267 [cellular protein metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902995 [positive regulation of phospholipid efflux]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-202
ENSP00000352471
ENST00000359492
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a; Epididymis secretory sperm binding protein
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Vascular diseases
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [amyloid-beta binding]
GO:0002576 [platelet degranulation]
GO:0002719 [negative regulation of cytokine production involved in immune response]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031072 [heat shock protein binding]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034371 [chylomicron remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034378 [chylomicron assembly]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0043691 [reverse cholesterol transport]
GO:0044267 [cellular protein metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902995 [positive regulation of phospholipid efflux]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-203
ENSP00000364469
ENST00000375320
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a; Epididymis secretory sperm binding protein
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Vascular diseases
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [amyloid-beta binding]
GO:0002576 [platelet degranulation]
GO:0002719 [negative regulation of cytokine production involved in immune response]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019899 [enzyme binding]
GO:0030139 [endocytic vesicle]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0031072 [heat shock protein binding]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034371 [chylomicron remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034378 [chylomicron assembly]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043687 [post-translational protein modification]
GO:0043691 [reverse cholesterol transport]
GO:0044267 [cellular protein metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902995 [positive regulation of phospholipid efflux]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-204
ENSP00000364472
ENST00000375323
P02647 [Direct mapping]
Apolipoprotein A-I Proapolipoprotein A-I Truncated apolipoprotein A-I
A0A024R3E3 [Target identity:100%; Query identity:100%]
Apolipoprotein A-I, isoform CRA_a; Epididymis secretory sperm binding protein
Show all
Metabolic proteins
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Human disease related genes
   Cardiovascular diseases
   Vascular diseases
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [amyloid-beta binding]
GO:0001932 [regulation of protein phosphorylation]
GO:0001935 [endothelial cell proliferation]
GO:0002576 [platelet degranulation]
GO:0002719 [negative regulation of cytokine production involved in immune response]
GO:0005102 [signaling receptor binding]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005769 [early endosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007584 [response to nutrient]
GO:0008035 [high-density lipoprotein particle binding]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008211 [glucocorticoid metabolic process]
GO:0008289 [lipid binding]
GO:0009986 [cell surface]
GO:0010804 [negative regulation of tumor necrosis factor-mediated signaling pathway]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010903 [negative regulation of very-low-density lipoprotein particle remodeling]
GO:0014012 [peripheral nervous system axon regeneration]
GO:0015485 [cholesterol binding]
GO:0015914 [phospholipid transport]
GO:0018158 [protein oxidation]
GO:0018206 [peptidyl-methionine modification]
GO:0019216 [regulation of lipid metabolic process]
GO:0019899 [enzyme binding]
GO:0019915 [lipid storage]
GO:0030139 [endocytic vesicle]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0030301 [cholesterol transport]
GO:0030325 [adrenal gland development]
GO:0031072 [heat shock protein binding]
GO:0031100 [animal organ regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0031410 [cytoplasmic vesicle]
GO:0032489 [regulation of Cdc42 protein signal transduction]
GO:0032691 [negative regulation of interleukin-1 beta production]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034190 [apolipoprotein receptor binding]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0034363 [intermediate-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034365 [discoidal high-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034371 [chylomicron remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034378 [chylomicron assembly]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0034774 [secretory granule lumen]
GO:0035025 [positive regulation of Rho protein signal transduction]
GO:0042157 [lipoprotein metabolic process]
GO:0042158 [lipoprotein biosynthetic process]
GO:0042493 [response to drug]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043627 [response to estrogen]
GO:0043687 [post-translational protein modification]
GO:0043691 [reverse cholesterol transport]
GO:0044267 [cellular protein metabolic process]
GO:0045499 [chemorepellent activity]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0050728 [negative regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050821 [protein stabilization]
GO:0050919 [negative chemotaxis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051180 [vitamin transport]
GO:0051345 [positive regulation of hydrolase activity]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0055085 [transmembrane transport]
GO:0055091 [phospholipid homeostasis]
GO:0055102 [lipase inhibitor activity]
GO:0060192 [negative regulation of lipase activity]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060354 [negative regulation of cell adhesion molecule production]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
GO:0070508 [cholesterol import]
GO:0070653 [high-density lipoprotein particle receptor binding]
GO:0071682 [endocytic vesicle lumen]
GO:0071813 [lipoprotein particle binding]
GO:0072562 [blood microparticle]
GO:0120009 [intermembrane lipid transfer]
GO:0120020 [cholesterol transfer activity]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1902995 [positive regulation of phospholipid efflux]
GO:1903561 [extracellular vesicle]
Show all
267 aa
30.8 kDa
Yes 0
APOA1-205
ENSP00000364478
ENST00000375329
F8W696 [Direct mapping]
Apolipoprotein A-I
Show all
Metabolic proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Cardiovascular diseases
   Vascular diseases
   Congenital disorders of metabolism
   Congenital disorders of lipid/glycolipid metabolism
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0034364 [high-density lipoprotein particle]
GO:0042157 [lipoprotein metabolic process]
Show all
245 aa
27.9 kDa
No 0

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