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PLAGL1
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  • PLAGL1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

PLAGL1
Synonyms LOT1, ZAC
Gene descriptioni

Full gene name according to HGNC.

PLAG1 like zinc finger 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Human disease related genes
Transcription factors
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 6
Cytoband q24.2
Chromosome location (bp) 143940300 - 144064599
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

22
Ensembl ENSG00000118495 (version 103.38)
Entrez gene 5325
HGNC HGNC:9046
UniProt Q9UM63 (UniProt - Evidence at protein level)
neXtProt NX_Q9UM63
Antibodypedia PLAGL1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 0

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
«
PLAGL1-201
PLAGL1-202
PLAGL1-203
PLAGL1-204
PLAGL1-205
PLAGL1-206
PLAGL1-207
PLAGL1-208
PLAGL1-209
PLAGL1-211
PLAGL1-213
PLAGL1-214
PLAGL1-215
PLAGL1-216
PLAGL1-219
PLAGL1-220
PLAGL1-223
PLAGL1-224
PLAGL1-225
PLAGL1-226
PLAGL1-227
PLAGL1-228
»


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
PLAGL1-201
ENSP00000346810
ENST00000354765
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-202
ENSP00000353734
ENST00000360537
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-203
ENSP00000356543
ENST00000367571
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-204
ENSP00000356544
ENST00000367572
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
411 aa
44.7 kDa
No 0
PLAGL1-205
ENSP00000376124
ENST00000392307
Q68DN7 [Direct mapping]
Zinc finger protein PLAGL1
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
252 aa
26.4 kDa
No 0
PLAGL1-206
ENSP00000400060
ENST00000416623
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-207
ENSP00000395960
ENST00000417959
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
411 aa
44.7 kDa
No 0
PLAGL1-208
ENSP00000392418
ENST00000437412
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
411 aa
44.7 kDa
No 0
PLAGL1-209
ENSP00000400929
ENST00000444202
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-211
ENSP00000486355
ENST00000625622
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-213
ENSP00000487447
ENST00000626294
A0A0D9SGF7 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
80 aa
8.9 kDa
No 0
PLAGL1-214
ENSP00000486711
ENST00000626373
A1YLA2 [Direct mapping]
Pleiomorphic adenoma gene-like protein 1; Pleomorphic adenoma gene-like 1; Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
12 aa
1.4 kDa
No 0
PLAGL1-215
ENSP00000486752
ENST00000626462
A0A0D9SFM8 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
74 aa
8.3 kDa
No 0
PLAGL1-216
ENSP00000485907
ENST00000627449
A0A0D9SEQ4 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
73 aa
8.2 kDa
No 0
PLAGL1-219
ENSP00000486632
ENST00000628651
A0A0D9SFI7 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
102 aa
11.3 kDa
No 0
PLAGL1-220
ENSP00000486763
ENST00000629195
A1YLA1 [Direct mapping]
Pleiomorphic adenoma gene-like protein 1; Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
64 aa
7.5 kDa
No 0
PLAGL1-223
ENSP00000496815
ENST00000647880
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
411 aa
44.7 kDa
No 0
PLAGL1-224
ENSP00000496874
ENST00000647988
A0A3B3IRN7 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
173 aa
19.9 kDa
No 0
PLAGL1-225
ENSP00000497492
ENST00000649211
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-226
ENSP00000496979
ENST00000649307
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-227
ENSP00000497363
ENST00000650125
Q9UM63 [Direct mapping]
Zinc finger protein PLAGL1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0016604 [nuclear body]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046872 [metal ion binding]
Show all
463 aa
50.8 kDa
No 0
PLAGL1-228
ENSP00000501459
ENST00000674357
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Endocrine and metabolic diseases
   Diabetes
Show all
GO:0000977 [RNA polymerase II transcription regulatory region sequence-specific DNA binding]
GO:0006357 [regulation of transcription by RNA polymerase II]
Show all
463 aa
50.8 kDa
No 0

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