We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q23.3
Chromosome location (bp)
137867214 - 137883312
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
TNFAIP3-201
TNFAIP3-202
TNFAIP3-203
TNFAIP3-204
TNFAIP3-206
TNFAIP3-207
TNFAIP3-208
TNFAIP3-209
TNFAIP3-210
TNFAIP3-211
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001922 [B-1 B cell homeostasis] GO:0002020 [protease binding] GO:0002237 [response to molecule of bacterial origin] GO:0002634 [regulation of germinal center formation] GO:0003677 [DNA binding] GO:0003824 [catalytic activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0004843 [thiol-dependent ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007010 [cytoskeleton organization] GO:0008152 [metabolic process] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016477 [cell migration] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016740 [transferase activity] GO:0016787 [hydrolase activity] GO:0018215 [protein phosphopantetheinylation] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0031397 [negative regulation of protein ubiquitination] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032703 [negative regulation of interleukin-2 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034140 [negative regulation of toll-like receptor 3 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0035523 [protein K29-linked deubiquitination] GO:0035871 [protein K11-linked deubiquitination] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043621 [protein self-association] GO:0045732 [positive regulation of protein catabolic process] GO:0045779 [negative regulation of bone resorption] GO:0045824 [negative regulation of innate immune response] GO:0046872 [metal ion binding] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050691 [regulation of defense response to virus by host] GO:0050728 [negative regulation of inflammatory response] GO:0050869 [negative regulation of B cell activation] GO:0061043 [regulation of vascular wound healing] GO:0061578 [Lys63-specific deubiquitinase activity] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding] GO:0070536 [protein K63-linked deubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0071108 [protein K48-linked deubiquitination] GO:0071222 [cellular response to lipopolysaccharide] GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0072573 [tolerance induction to lipopolysaccharide] GO:0090291 [negative regulation of osteoclast proliferation] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1990168 [protein K33-linked deubiquitination] GO:2000349 [negative regulation of CD40 signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q5VXR0 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Q5VXQ9 [Direct mapping] Tumor necrosis factor alpha-induced protein 3
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001922 [B-1 B cell homeostasis] GO:0002020 [protease binding] GO:0002237 [response to molecule of bacterial origin] GO:0002634 [regulation of germinal center formation] GO:0002677 [negative regulation of chronic inflammatory response] GO:0003677 [DNA binding] GO:0003824 [catalytic activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0004843 [thiol-dependent ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007010 [cytoskeleton organization] GO:0008022 [protein C-terminus binding] GO:0008152 [metabolic process] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016477 [cell migration] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016740 [transferase activity] GO:0016787 [hydrolase activity] GO:0018215 [protein phosphopantetheinylation] GO:0019900 [kinase binding] GO:0030177 [positive regulation of Wnt signaling pathway] GO:0031397 [negative regulation of protein ubiquitination] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0032495 [response to muramyl dipeptide] GO:0032691 [negative regulation of interleukin-1 beta production] GO:0032703 [negative regulation of interleukin-2 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034140 [negative regulation of toll-like receptor 3 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034148 [negative regulation of toll-like receptor 5 signaling pathway] GO:0035523 [protein K29-linked deubiquitination] GO:0035871 [protein K11-linked deubiquitination] GO:0042802 [identical protein binding] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043621 [protein self-association] GO:0045732 [positive regulation of protein catabolic process] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045779 [negative regulation of bone resorption] GO:0045824 [negative regulation of innate immune response] GO:0046872 [metal ion binding] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050691 [regulation of defense response to virus by host] GO:0050728 [negative regulation of inflammatory response] GO:0050869 [negative regulation of B cell activation] GO:0060548 [negative regulation of cell death] GO:0061043 [regulation of vascular wound healing] GO:0061578 [Lys63-specific deubiquitinase activity] GO:0070062 [extracellular exosome] GO:0070301 [cellular response to hydrogen peroxide] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0070429 [negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway] GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0070530 [K63-linked polyubiquitin modification-dependent protein binding] GO:0070536 [protein K63-linked deubiquitination] GO:0070936 [protein K48-linked ubiquitination] GO:0071108 [protein K48-linked deubiquitination] GO:0071222 [cellular response to lipopolysaccharide] GO:0071947 [protein deubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0072573 [tolerance induction to lipopolysaccharide] GO:0072666 [establishment of protein localization to vacuole] GO:0090291 [negative regulation of osteoclast proliferation] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1903364 [positive regulation of cellular protein catabolic process] GO:1990168 [protein K33-linked deubiquitination] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2000349 [negative regulation of CD40 signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Large Deletions COSMIC Frameshift Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
