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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:27.0 nTPM
HPA:27.0 nTPM
GTEx:31.6 nTPM
FANTOM5:165.0 Scaled Tags Per Million
Pig:84.3 nTPM
Mouse:81.3 nTPM
Allen mouse:7.2 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 27.0
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 22.0
2019 Male, age 18, unknown 26.9
2666 Male, age 74, left hemisphere 26.6
2586 Male, age 75, left hemisphere 24.2
2219 Male, age 76, both hemispheres 21.4
2828 Female, age 72, unknown 21.1
1833 Male, age 53, unknown 20.9
1830 Male, age 51, unknown 20.7
1827 Male, age 72, unknown 20.0
2411 Female, age 72, unknown 19.8
1870 Female, age 42, unknown 18.6
Dorsal raphe nucleus
nTPM: 19.9
2047 Male, age 72, unknown 21.6
2750 Male, age 76, both hemispheres 21.0
2298 Female, age 72, unknown 19.3
1828 Male, age 53, unknown 18.8
2016 Female, age 72, unknown 18.7
Inferior colliculus
nTPM: 19.6
2849 Male, age 72, unknown 23.8
1848 Female, age 42, unknown 19.1
2097 Female, age 72, unknown 18.2
1890 Male, age 53, unknown 17.2
Median raphe nucleus
nTPM: 27.0
2220 Male, age 76, midline 27.0
Pedunculopontine tegmental nucleus
nTPM: 22.3
2334 Male, age 80, both hemispheres 23.6
2338 Male, age 61, both hemispheres 22.5
1921 Female, age 85, both hemispheres 20.8
Periaquaductal grey, anterior
nTPM: 19.7
1795 Male, age 51, unknown 21.6
1947 Male, age 18, unknown 18.8
2502 Female, age 75, unknown 18.5
Periaquaductal grey, dorsal
nTPM: 20.2
2850 Male, age 76, both hemispheres 26.1
1831 Male, age 72, unknown 21.3
1840 Male, age 53, unknown 17.5
2464 Female, age 72, unknown 15.9
Periaquaductal grey, lateral
nTPM: 19.9
2272 Male, age 74, both hemispheres 23.5
2140 Male, age 76, both hemispheres 19.8
2053 Male, age 18, unknown 16.3
Pretectal area
nTPM: 26.0
1817 Female, age 42, unknown 38.0
1816 Male, age 51, unknown 36.5
2007 Male, age 72, unknown 31.8
1815 Male, age 53, unknown 29.9
1944 Female, age 72, unknown 29.2
2667 Female, age 75, unknown 27.1
2224 Female, age 72, unknown 19.7
2273 Male, age 74, both hemispheres 19.3
2407 Male, age 75, both hemispheres 18.3
2825 Male, age 18, unknown 18.2
2316 Male, age 76, right hemisphere 17.4
Red nucleus
nTPM: 20.2
2785 Male, age 18, unknown 26.3
2725 Female, age 75, unknown 21.7
1821 Female, age 72, unknown 21.4
2588 Male, age 74, left hemisphere 20.5
2823 Male, age 76, right hemisphere 20.5
2503 Female, age 72, unknown 20.0
2227 Male, age 72, unknown 19.6
1865 Male, age 51, unknown 19.1
2584 Male, age 75, left hemisphere 18.9
2769 Male, age 72, unknown 18.4
1904 Male, age 53, unknown 18.3
1954 Female, age 42, unknown 17.5
Substantia nigra
nTPM: 23.2
1889 Female, age 72, unknown 29.1
2665 Male, age 74, both hemispheres 29.0
1941 Male, age 53, unknown 25.8
2409 Female, age 72, unknown 23.9
1916 Female, age 42, unknown 23.6
2583 Male, age 75, right hemisphere 22.9
1851 Male, age 51, unknown 21.8
2699 Male, age 18, unknown 21.2
2590 Female, age 75, unknown 17.9
2241 Male, age 72, unknown 16.7
Superior colliculus
nTPM: 22.6
2668 Female, age 75, unknown 25.8
2261 Male, age 18, unknown 25.6
1796 Male, age 53, unknown 24.8
1913 Female, age 42, unknown 24.1
2087 Female, age 72, unknown 24.0
2587 Male, age 74, left hemisphere 22.8
1995 Male, age 72, unknown 20.6
1839 Male, age 51, unknown 20.1
1895 Male, age 76, right hemisphere 19.1
2664 Male, age 75, both hemispheres 18.9
Ventral tegmental area
nTPM: 21.6
2218 Male, age 76, both hemispheres 25.0
2223 Female, age 72, unknown 23.2
2410 Female, age 72, unknown 22.7
2021 Male, age 53, unknown 22.0
1915 Female, age 42, unknown 20.1
1942 Male, age 51, unknown 16.7

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 31.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 31.6
Samples: 139

Max nTPM: 53.7
Min nTPM: 23.0
Std nTPM: 4.4
Median nTPM: 31.3
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 53.7
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 46.8
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 43.3
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 40.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 40.5
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 40.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 39.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 38.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 38.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 38.5
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 38.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 37.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 37.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 37.0
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 36.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 36.6
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 36.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 36.0
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 35.9
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 35.8
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 35.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 35.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 34.9
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 34.8
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 34.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 34.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 34.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 34.2
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 34.2
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 34.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 34.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 34.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 33.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 33.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 33.7
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 33.3
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 33.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 33.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 33.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 33.0
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 33.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 32.9
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 32.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 32.9
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 32.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 32.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 32.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 32.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 32.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 32.3
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 32.3
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 32.2
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 32.2
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 32.0
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 31.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 31.9
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 31.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 31.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 31.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 31.5
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 31.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 31.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 31.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 31.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 31.4
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 31.3
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 31.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 31.3
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 31.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 31.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 31.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 31.2
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 31.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 31.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 31.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 31.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 30.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 30.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 30.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 30.8
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 30.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 30.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 30.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 30.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 30.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 30.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 30.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 30.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 30.1
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 29.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 29.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 29.7
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 29.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 29.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 29.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 29.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 29.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 29.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 29.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 29.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 29.2
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 29.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 29.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 29.0
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 29.0
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 28.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 28.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 28.8
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 28.8
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 28.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 28.5
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 28.5
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 28.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 28.3
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 28.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 28.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 27.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 27.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 27.5
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 27.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 27.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 27.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 27.2
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 27.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 26.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 26.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 26.3
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 26.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 25.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 25.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 25.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 25.1
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 24.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 24.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 24.5
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 24.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 24.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 23.0
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 23.0
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 165.0
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 165.0
FF:10158-103A5 76 years, female 165.0

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 84.3
Pig sample Sample description nTPM
Midbrain
nTPM: 84.3
Samples: 4

Max nTPM: 96.9
Min nTPM: 69.7
Sample A Female 86.3
Sample B Female 69.7
Sample C Male 96.9
Sample D Male 84.4
Periaqueductal gray
nTPM: 68.6
Samples: 3

Max nTPM: 74.7
Min nTPM: 62.6
Sample B Female 62.6
Sample C Male 74.7
Sample D Male 68.4
Substantia nigra
nTPM: 73.7
Samples: 4

Max nTPM: 88.3
Min nTPM: 64.0
Sample A Female 88.3
Sample B Female 65.6
Sample C Male 77.0
Sample D Male 64.0
Superior colliculi
nTPM: 82.7
Samples: 4

Max nTPM: 96.1
Min nTPM: 63.0
Sample A Female 89.3
Sample B Female 63.0
Sample C Male 96.1
Sample D Male 82.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 81.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 81.3
Samples: 4

Max nTPM: 84.5
Min nTPM: 78.9
Sample A Male 78.9
Sample B Male 84.5
Sample C Female 82.6
Sample D Female 79.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 7.2
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 7.2
68445113 Antisense, RP_050111_02_G10, Mouse strain C57BL/6J (56 days, male) 13.9
881 Antisense, RP_Baylor_102992, Mouse strain C57BL/6J (56 days, male) 0.5

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