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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:60.5 nTPM
HPA:60.5 nTPM
GTEx:29.8 nTPM
FANTOM5:204.6 Scaled Tags Per Million
Pig:50.3 nTPM
Mouse:44.9 nTPM
Allen mouse:1.5 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 60.5
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 36.6
2586 Male, age 75, left hemisphere 59.8
2828 Female, age 72, unknown 50.5
2666 Male, age 74, left hemisphere 49.2
1827 Male, age 72, unknown 42.9
1870 Female, age 42, unknown 34.7
1830 Male, age 51, unknown 31.3
2411 Female, age 72, unknown 28.0
1833 Male, age 53, unknown 26.0
2019 Male, age 18, unknown 24.3
2219 Male, age 76, both hemispheres 19.8
Dorsal raphe nucleus
nTPM: 39.4
2016 Female, age 72, unknown 49.8
2047 Male, age 72, unknown 41.0
1828 Male, age 53, unknown 38.5
2298 Female, age 72, unknown 34.8
2750 Male, age 76, both hemispheres 32.9
Inferior colliculus
nTPM: 39.0
1848 Female, age 42, unknown 43.3
2097 Female, age 72, unknown 41.9
1890 Male, age 53, unknown 35.4
2849 Male, age 72, unknown 35.2
Median raphe nucleus
nTPM: 29.3
2220 Male, age 76, midline 29.3
Pedunculopontine tegmental nucleus
nTPM: 29.6
2334 Male, age 80, both hemispheres 32.0
1921 Female, age 85, both hemispheres 28.6
2338 Male, age 61, both hemispheres 28.4
Periaquaductal grey, anterior
nTPM: 60.5
1947 Male, age 18, unknown 76.4
2502 Female, age 75, unknown 54.0
1795 Male, age 51, unknown 50.9
Periaquaductal grey, dorsal
nTPM: 50.2
1831 Male, age 72, unknown 65.0
1840 Male, age 53, unknown 47.9
2850 Male, age 76, both hemispheres 47.4
2464 Female, age 72, unknown 40.2
Periaquaductal grey, lateral
nTPM: 48.5
2053 Male, age 18, unknown 56.4
2140 Male, age 76, both hemispheres 46.4
2272 Male, age 74, both hemispheres 42.7
Pretectal area
nTPM: 42.5
2273 Male, age 74, both hemispheres 57.3
1944 Female, age 72, unknown 52.5
1816 Male, age 51, unknown 47.0
2407 Male, age 75, both hemispheres 46.4
2825 Male, age 18, unknown 43.3
2667 Female, age 75, unknown 42.2
1815 Male, age 53, unknown 40.6
1817 Female, age 42, unknown 37.4
2316 Male, age 76, right hemisphere 36.6
2224 Female, age 72, unknown 33.9
2007 Male, age 72, unknown 30.7
Red nucleus
nTPM: 32.7
2725 Female, age 75, unknown 46.1
2503 Female, age 72, unknown 39.5
2584 Male, age 75, left hemisphere 39.0
2823 Male, age 76, right hemisphere 37.0
1954 Female, age 42, unknown 35.0
1865 Male, age 51, unknown 31.2
1821 Female, age 72, unknown 30.4
2588 Male, age 74, left hemisphere 28.9
2227 Male, age 72, unknown 27.7
1904 Male, age 53, unknown 26.9
2769 Male, age 72, unknown 26.9
2785 Male, age 18, unknown 24.3
Substantia nigra
nTPM: 38.3
1941 Male, age 53, unknown 69.9
2583 Male, age 75, right hemisphere 47.7
1889 Female, age 72, unknown 37.6
2699 Male, age 18, unknown 36.9
2590 Female, age 75, unknown 33.3
2665 Male, age 74, both hemispheres 32.7
2241 Male, age 72, unknown 32.3
1916 Female, age 42, unknown 32.0
1851 Male, age 51, unknown 31.5
2409 Female, age 72, unknown 29.3
Superior colliculus
nTPM: 47.9
2664 Male, age 75, both hemispheres 67.7
1995 Male, age 72, unknown 63.6
2261 Male, age 18, unknown 54.5
1913 Female, age 42, unknown 50.0
2087 Female, age 72, unknown 49.4
2587 Male, age 74, left hemisphere 44.4
1839 Male, age 51, unknown 44.0
1796 Male, age 53, unknown 41.0
2668 Female, age 75, unknown 40.1
1895 Male, age 76, right hemisphere 24.7
Ventral tegmental area
nTPM: 35.1
1942 Male, age 51, unknown 51.4
2021 Male, age 53, unknown 38.3
1915 Female, age 42, unknown 33.2
2218 Male, age 76, both hemispheres 30.9
2410 Female, age 72, unknown 28.7
2223 Female, age 72, unknown 28.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 29.8
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 29.8
Samples: 139

Max nTPM: 78.3
Min nTPM: 8.7
Std nTPM: 11.5
Median nTPM: 27.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 78.3
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 65.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 61.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 59.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 56.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 55.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 51.8
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 49.4
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 49.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 46.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 45.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 45.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 45.0
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 44.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 43.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 43.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 42.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 42.2
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 42.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 41.9
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 41.9
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 41.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 41.7
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 40.4
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 40.2
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 40.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 39.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 39.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 38.3
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 38.2
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 37.7
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 37.6
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 37.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 37.1
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 36.8
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 36.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 34.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 34.2
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 34.2
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 34.0
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 33.9
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 33.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 33.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 33.1
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 32.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 32.7
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 32.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 32.6
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 32.4
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 32.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 31.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 31.5
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 31.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 30.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 30.1
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 29.9
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 29.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 29.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 29.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 29.5
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 29.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 29.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 29.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 28.9
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 28.7
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 28.7
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 28.6
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 28.4
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 27.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 27.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 27.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 27.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 27.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 27.3
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 27.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 27.0
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 26.4
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 26.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 25.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 25.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 25.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 24.9
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 24.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 24.8
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 24.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 24.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 24.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 24.1
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 23.5
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 23.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 22.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 22.7
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 22.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 22.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 22.6
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 22.5
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 22.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 22.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 22.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 22.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 22.0
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 21.4
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 21.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 21.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 21.0
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 20.7
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 20.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 20.3
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 20.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 20.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 20.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 20.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 20.0
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 20.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 19.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 19.7
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 19.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 19.4
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 19.4
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 19.4
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 19.0
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 18.9
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 18.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 18.6
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 17.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 17.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 17.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 17.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 17.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 16.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 16.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 16.4
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 15.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 15.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 14.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 14.3
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 11.8
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 9.9
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 8.7
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 204.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 204.6
FF:10158-103A5 76 years, female 204.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 50.3
Pig sample Sample description nTPM
Midbrain
nTPM: 50.3
Samples: 4

Max nTPM: 107.0
Min nTPM: 30.3
Sample A Female 31.6
Sample B Female 30.3
Sample C Male 107.0
Sample D Male 32.1
Periaqueductal gray
nTPM: 29.3
Samples: 3

Max nTPM: 32.9
Min nTPM: 25.7
Sample B Female 29.3
Sample C Male 32.9
Sample D Male 25.7
Substantia nigra
nTPM: 28.3
Samples: 4

Max nTPM: 33.8
Min nTPM: 20.8
Sample A Female 33.8
Sample B Female 28.7
Sample C Male 29.9
Sample D Male 20.8
Superior colliculi
nTPM: 45.8
Samples: 4

Max nTPM: 78.8
Min nTPM: 30.8
Sample A Female 33.6
Sample B Female 30.8
Sample C Male 78.8
Sample D Male 39.9

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 44.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 44.9
Samples: 4

Max nTPM: 50.8
Min nTPM: 40.6
Sample A Male 40.6
Sample B Male 44.7
Sample C Female 50.8
Sample D Female 43.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 1.5
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 1.5
73818756 Antisense, RP_050921_02_B08, Mouse strain C57BL/6J (56 days, male) 1.5
71763534 Antisense, RP_050921_02_B08, Mouse strain C57BL/6J (56 days, male) 0.6

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