We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
PTK2B
SECTIONS
  • TISSUE
  • BRAIN
  • SINGLE CELL TYPE
  • TISSUE CELL TYPE
  • PATHOLOGY
  • DISEASE
  • IMMUNE CELL
  • BLOOD PROTEIN
  • SUBCELLULAR
  • CELL LINE
  • STRUCTURE
  • METABOLIC
ABOUT
  • INTRODUCTION
  • HISTORY
  • ORGANIZATION
  • PUBLICATIONS
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • ACKNOWLEDGMENTS
  • CONTACT
NEWS
  • NEWS ARTICLES
  • PRESS ROOM
LEARN
  • DICTIONARY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
  • METHODS
  • EDUCATIONAL VIDEOS
DATA
  • DOWNLOADABLE DATA
  • PUBLICATION DATA
  • RELEASE HISTORY
  • SARS-COV-2
HELP
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • HELP & FAQ
  • PRIVACY STATEMENT
  • LICENCE & CITATION
Fields »
Search result

Field
Term
Gene name
Class
Subclass
Class
Keyword
Chromosome
External id
Tissue
Cell type
Expression
Patient ID
Tissue
Category
Cluster
Reliability
Brain region
Category
Brain region
Category
Brain region
Category
Reliability
Cell type
Category
Cluster
Tissue
Cell type
Enrichment
Cancer
Prognosis
Cancer
Category
Cell type
Category
Cell lineage
Category
Cluster
Annotation
Disease
Location
Searches
Location
Cell line
Type
Phase
Reliability
Cancer type
Category
Cluster
Pathway
Category
Score
Score
Score
Validation
Validation
Validation
Validation
Antibodies
Protein structure
In atlas
Column


  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

  • TISSUE CELL

  • PATHOLOGY

  • DISEASE

  • IMMUNE

  • BLOOD

  • SUBCELL

  • CELL LINE

  • STRUCTURE

  • METABOLIC

  • PTK2B
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

PTK2B
Synonyms CADTK, CAKB, FAK2, PTK, PYK2, RAFTK
Gene descriptioni

Full gene name according to HGNC.

Protein tyrosine kinase 2 beta
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 8
Cytoband p21.2
Chromosome location (bp) 27311482 - 27459391
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

9
Ensembl ENSG00000120899 (version 103.38)
Entrez gene 2185
HGNC HGNC:9612
UniProt Q14289 (UniProt - Evidence at protein level)
neXtProt NX_Q14289
Antibodypedia PTK2B antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 607

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PTK2B-201
PTK2B-203
PTK2B-204
PTK2B-205
PTK2B-210
PTK2B-211
PTK2B-214
PTK2B-216
PTK2B-217


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
PTK2B-201
ENSP00000332816
ENST00000346049
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0086100 [endothelin receptor signaling pathway]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
1009 aa
115.9 kDa
No 0
PTK2B-203
ENSP00000380638
ENST00000397501
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000166 [nucleotide binding]
GO:0000302 [response to reactive oxygen species]
GO:0001525 [angiogenesis]
GO:0001556 [oocyte maturation]
GO:0001666 [response to hypoxia]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0006970 [response to osmotic stress]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009612 [response to mechanical stimulus]
GO:0009725 [response to hormone]
GO:0009749 [response to glucose]
GO:0010226 [response to lithium ion]
GO:0010243 [response to organonitrogen compound]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010656 [negative regulation of muscle cell apoptotic process]
GO:0010752 [regulation of cGMP-mediated signaling]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014009 [glial cell proliferation]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030279 [negative regulation of ossification]
GO:0030307 [positive regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031175 [neuron projection development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035902 [response to immobilization stress]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042220 [response to cocaine]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043149 [stress fiber assembly]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043423 [3-phosphoinositide-dependent protein kinase binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043534 [blood vessel endothelial cell migration]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0044877 [protein-containing complex binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045428 [regulation of nitric oxide biosynthetic process]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045453 [bone resorption]
GO:0045471 [response to ethanol]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045727 [positive regulation of translation]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051000 [positive regulation of nitric-oxide synthase activity]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051591 [response to cAMP]
GO:0051592 [response to calcium ion]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0060292 [long-term synaptic depression]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0071498 [cellular response to fluid shear stress]
GO:0086100 [endothelin receptor signaling pathway]
GO:0090630 [activation of GTPase activity]
GO:0097440 [apical dendrite]
GO:0098794 [postsynapse]
GO:0098978 [glutamatergic synapse]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000060 [positive regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
GO:2000573 [positive regulation of DNA biosynthetic process]
Show all
1009 aa
115.9 kDa
No 0
PTK2B-204
ENSP00000416174
ENST00000412793
C9JHV9 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
213 aa
24.9 kDa
No 0
PTK2B-205
ENSP00000391995
ENST00000420218
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0086100 [endothelin receptor signaling pathway]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
967 aa
111.2 kDa
No 0
PTK2B-210
ENSP00000427931
ENST00000517339
Q14289 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002040 [sprouting angiogenesis]
GO:0002250 [adaptive immune response]
GO:0002315 [marginal zone B cell differentiation]
GO:0002376 [immune system process]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0004972 [NMDA glutamate receptor activity]
GO:0005102 [signaling receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008285 [negative regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010758 [regulation of macrophage chemotaxis]
GO:0010976 [positive regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0017146 [NMDA selective glutamate receptor complex]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030027 [lamellipodium]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030335 [positive regulation of cell migration]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030500 [regulation of bone mineralization]
GO:0030502 [negative regulation of bone mineralization]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032960 [regulation of inositol trisphosphate biosynthetic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038110 [interleukin-2-mediated signaling pathway]
GO:0042127 [regulation of cell population proliferation]
GO:0042976 [activation of Janus kinase activity]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043197 [dendritic spine]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044297 [cell body]
GO:0045087 [innate immune response]
GO:0045453 [bone resorption]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0060291 [long-term synaptic potentiation]
GO:0065003 [protein-containing complex assembly]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071300 [cellular response to retinoic acid]
GO:0086100 [endothelin receptor signaling pathway]
GO:0097440 [apical dendrite]
GO:2000058 [regulation of ubiquitin-dependent protein catabolic process]
GO:2000114 [regulation of establishment of cell polarity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000310 [regulation of NMDA receptor activity]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
GO:2000538 [positive regulation of B cell chemotaxis]
Show all
967 aa
111.2 kDa
No 0
PTK2B-211
ENSP00000428837
ENST00000519512
H0YB74 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
194 aa
21.7 kDa
No 0
PTK2B-214
ENSP00000430404
ENST00000521164
E5RK84 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
103 aa
11.6 kDa
No 0
PTK2B-216
ENSP00000429694
ENST00000522338
E5RHL2 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
68 aa
7.6 kDa
No 0
PTK2B-217
ENSP00000428271
ENST00000522517
E5RJ77 [Direct mapping]
Protein-tyrosine kinase 2-beta
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002688 [regulation of leukocyte chemotaxis]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030155 [regulation of cell adhesion]
GO:0030334 [regulation of cell migration]
GO:0030500 [regulation of bone mineralization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0042127 [regulation of cell population proliferation]
GO:0045765 [regulation of angiogenesis]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
184 aa
21.5 kDa
No 0

Contact

  • NEWS ARTICLES
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.