We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
CXCR4
SECTIONS
  • TISSUE
  • BRAIN
  • SINGLE CELL TYPE
  • TISSUE CELL TYPE
  • PATHOLOGY
  • DISEASE
  • IMMUNE CELL
  • BLOOD PROTEIN
  • SUBCELLULAR
  • CELL LINE
  • STRUCTURE
  • METABOLIC
ABOUT
  • INTRODUCTION
  • HISTORY
  • ORGANIZATION
  • PUBLICATIONS
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • ACKNOWLEDGMENTS
  • CONTACT
NEWS
  • NEWS ARTICLES
  • PRESS ROOM
LEARN
  • DICTIONARY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
  • METHODS
  • EDUCATIONAL VIDEOS
DATA
  • DOWNLOADABLE DATA
  • PUBLICATION DATA
  • RELEASE HISTORY
  • SARS-COV-2
HELP
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • HELP & FAQ
  • PRIVACY STATEMENT
  • LICENCE & CITATION
Fields »
Search result

Field
Term
Gene name
Class
Subclass
Class
Keyword
Chromosome
External id
Tissue
Cell type
Expression
Patient ID
Tissue
Category
Cluster
Reliability
Brain region
Category
Brain region
Category
Brain region
Category
Reliability
Cell type
Category
Cluster
Tissue
Cell type
Enrichment
Cancer
Prognosis
Cancer
Category
Cell type
Category
Cell lineage
Category
Cluster
Annotation
Disease
Location
Searches
Location
Cell line
Type
Phase
Reliability
Cancer type
Category
Cluster
Pathway
Category
Score
Score
Score
Validation
Validation
Validation
Validation
Antibodies
Protein structure
In atlas
Column


  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

  • TISSUE CELL

  • PATHOLOGY

  • DISEASE

  • IMMUNE

  • BLOOD

  • SUBCELL

  • CELL LINE

  • STRUCTURE

  • METABOLIC

  • CXCR4
PROTEIN STRUCTURE
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

CXCR4
Synonyms CD184, D2S201E, fusin, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R
Gene descriptioni

Full gene name according to HGNC.

C-X-C motif chemokine receptor 4
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
CD markers
Disease related genes
FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 2
Cytoband q22.1
Chromosome location (bp) 136114349 - 136118149
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
Ensembl ENSG00000121966 (version 103.38)
Entrez gene 7852
HGNC HGNC:2561
UniProt P61073 (UniProt - Evidence at protein level)
neXtProt NX_P61073
Antibodypedia CXCR4 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 141

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

Off
On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CXCR4-201
CXCR4-202


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
CXCR4-201
ENSP00000241393
ENST00000241393
P61073 [Direct mapping]
C-X-C chemokine receptor type 4
Show all
CD markers
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001618 [virus receptor activity]
GO:0001666 [response to hypoxia]
GO:0002407 [dendritic cell chemotaxis]
GO:0003779 [actin binding]
GO:0004930 [G protein-coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0009615 [response to virus]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016493 [C-C chemokine receptor activity]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019955 [cytokine binding]
GO:0019957 [C-C chemokine binding]
GO:0022008 [neurogenesis]
GO:0030054 [cell junction]
GO:0030155 [regulation of cell adhesion]
GO:0031252 [cell leading edge]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032027 [myosin light chain binding]
GO:0032991 [protein-containing complex]
GO:0038147 [C-X-C motif chemokine 12 receptor activity]
GO:0038160 [CXCL12-activated CXCR4 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043130 [ubiquitin binding]
GO:0043217 [myelin maintenance]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050920 [regulation of chemotaxis]
GO:0060326 [cell chemotaxis]
GO:0070062 [extracellular exosome]
GO:0071345 [cellular response to cytokine stimulus]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:2000448 [positive regulation of macrophage migration inhibitory factor signaling pathway]
Show all
352 aa
39.7 kDa
No 7
CXCR4-202
ENSP00000386884
ENST00000409817
P61073 [Direct mapping]
C-X-C chemokine receptor type 4
Show all
CD markers
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Immune system diseases
   Primary immunodeficiency
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001618 [virus receptor activity]
GO:0001666 [response to hypoxia]
GO:0001764 [neuron migration]
GO:0002064 [epithelial cell development]
GO:0002407 [dendritic cell chemotaxis]
GO:0003779 [actin binding]
GO:0004930 [G protein-coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G protein-coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0008038 [neuron recognition]
GO:0009615 [response to virus]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0014823 [response to activity]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0016477 [cell migration]
GO:0016493 [C-C chemokine receptor activity]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019064 [fusion of virus membrane with host plasma membrane]
GO:0019722 [calcium-mediated signaling]
GO:0019955 [cytokine binding]
GO:0019957 [C-C chemokine binding]
GO:0022008 [neurogenesis]
GO:0022029 [telencephalon cell migration]
GO:0030054 [cell junction]
GO:0030155 [regulation of cell adhesion]
GO:0030335 [positive regulation of cell migration]
GO:0031252 [cell leading edge]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032027 [myosin light chain binding]
GO:0032991 [protein-containing complex]
GO:0035470 [positive regulation of vascular wound healing]
GO:0035690 [cellular response to drug]
GO:0038147 [C-X-C motif chemokine 12 receptor activity]
GO:0038160 [CXCL12-activated CXCR4 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043067 [regulation of programmed cell death]
GO:0043130 [ubiquitin binding]
GO:0043217 [myelin maintenance]
GO:0043278 [response to morphine]
GO:0045446 [endothelial cell differentiation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0050769 [positive regulation of neurogenesis]
GO:0050792 [regulation of viral process]
GO:0050920 [regulation of chemotaxis]
GO:0050921 [positive regulation of chemotaxis]
GO:0050965 [detection of temperature stimulus involved in sensory perception of pain]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0051924 [regulation of calcium ion transport]
GO:0060048 [cardiac muscle contraction]
GO:0060326 [cell chemotaxis]
GO:0061154 [endothelial tube morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071345 [cellular response to cytokine stimulus]
GO:0120162 [positive regulation of cold-induced thermogenesis]
GO:1903861 [positive regulation of dendrite extension]
GO:1905322 [positive regulation of mesenchymal stem cell migration]
GO:1990478 [response to ultrasound]
GO:2000448 [positive regulation of macrophage migration inhibitory factor signaling pathway]
Show all
356 aa
40.2 kDa
No 7

Contact

  • NEWS ARTICLES
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.