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LRP1
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  • LRP1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

LRP1
Synonyms A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R1, LRP, LRP1A
Gene descriptioni

Full gene name according to HGNC.

LDL receptor related protein 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Candidate cardiovascular disease genes
CD markers
Disease related genes
Plasma proteins
Potential drug targets
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Membrane
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 12
Cytoband q13.3
Chromosome location (bp) 57128483 - 57213361
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

6
Ensembl ENSG00000123384 (version 103.38)
Entrez gene 4035
HGNC HGNC:6692
UniProt Q07954 (UniProt - Evidence at protein level)
neXtProt NX_Q07954
Antibodypedia LRP1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more


PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
LRP1-201
LRP1-202
LRP1-204
LRP1-206
LRP1-207
LRP1-208


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
LRP1-201
ENSP00000243077
ENST00000243077
Q07954 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1 Low-density lipoprotein receptor-related protein 1 85 kDa subunit Low-density lipoprotein receptor-related protein 1 515 kDa subunit Low-density lipoprotein receptor-related protein 1 intracellular domain
Show all
CD markers
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [amyloid-beta binding]
GO:0002020 [protease binding]
GO:0002265 [astrocyte activation involved in immune response]
GO:0003723 [RNA binding]
GO:0005041 [low-density lipoprotein particle receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0005925 [focal adhesion]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006909 [phagocytosis]
GO:0007041 [lysosomal transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007205 [protein kinase C-activating G protein-coupled receptor signaling pathway]
GO:0007275 [multicellular organism development]
GO:0007568 [aging]
GO:0008283 [cell population proliferation]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010942 [positive regulation of cell death]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016964 [alpha-2 macroglobulin receptor activity]
GO:0021987 [cerebral cortex development]
GO:0030054 [cell junction]
GO:0030136 [clathrin-coated vesicle]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030226 [apolipoprotein receptor activity]
GO:0030425 [dendrite]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0032050 [clathrin heavy chain binding]
GO:0032092 [positive regulation of protein binding]
GO:0032370 [positive regulation of lipid transport]
GO:0032374 [regulation of cholesterol transport]
GO:0032429 [regulation of phospholipase A2 activity]
GO:0032593 [insulin-responsive compartment]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034185 [apolipoprotein binding]
GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0035909 [aorta morphogenesis]
GO:0038023 [signaling receptor activity]
GO:0038024 [cargo receptor activity]
GO:0042157 [lipoprotein metabolic process]
GO:0042953 [lipoprotein transport]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0044242 [cellular lipid catabolic process]
GO:0044295 [axonal growth cone]
GO:0044877 [protein-containing complex binding]
GO:0045056 [transcytosis]
GO:0045177 [apical part of cell]
GO:0045202 [synapse]
GO:0045773 [positive regulation of axon extension]
GO:0045807 [positive regulation of endocytosis]
GO:0046872 [metal ion binding]
GO:0048691 [positive regulation of axon extension involved in regeneration]
GO:0048694 [positive regulation of collateral sprouting of injured axon]
GO:0050766 [positive regulation of phagocytosis]
GO:0051222 [positive regulation of protein transport]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0060548 [negative regulation of cell death]
GO:0061642 [chemoattraction of axon]
GO:0070325 [lipoprotein particle receptor binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0097242 [amyloid-beta clearance]
GO:0098797 [plasma membrane protein complex]
GO:0150051 [postsynaptic Golgi apparatus]
GO:0150093 [amyloid-beta clearance by transcytosis]
GO:0150094 [amyloid-beta clearance by cellular catabolic process]
GO:0150104 [transport across blood-brain barrier]
GO:1900149 [positive regulation of Schwann cell migration]
GO:1900223 [positive regulation of amyloid-beta clearance]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1904109 [positive regulation of cholesterol import]
GO:1904300 [positive regulation of transcytosis]
GO:1904646 [cellular response to amyloid-beta]
GO:1904754 [positive regulation of vascular associated smooth muscle cell migration]
GO:1905049 [negative regulation of metallopeptidase activity]
GO:1905167 [positive regulation of lysosomal protein catabolic process]
GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
4544 aa
504.6 kDa
Yes 1
LRP1-202
ENSP00000341264
ENST00000338962
Q07954 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1 Low-density lipoprotein receptor-related protein 1 85 kDa subunit Low-density lipoprotein receptor-related protein 1 515 kDa subunit Low-density lipoprotein receptor-related protein 1 intracellular domain
Show all
CD markers
Transporters
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Potential drug targets
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0001540 [amyloid-beta binding]
GO:0002265 [astrocyte activation involved in immune response]
GO:0003723 [RNA binding]
GO:0005041 [low-density lipoprotein particle receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [clathrin-coated pit]
GO:0005925 [focal adhesion]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0006909 [phagocytosis]
GO:0007041 [lysosomal transport]
GO:0007275 [multicellular organism development]
GO:0010715 [regulation of extracellular matrix disassembly]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010942 [positive regulation of cell death]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016964 [alpha-2 macroglobulin receptor activity]
GO:0030054 [cell junction]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030226 [apolipoprotein receptor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031623 [receptor internalization]
GO:0032050 [clathrin heavy chain binding]
GO:0032092 [positive regulation of protein binding]
GO:0032370 [positive regulation of lipid transport]
GO:0032374 [regulation of cholesterol transport]
GO:0032429 [regulation of phospholipase A2 activity]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034185 [apolipoprotein binding]
GO:0035909 [aorta morphogenesis]
GO:0038023 [signaling receptor activity]
GO:0038024 [cargo receptor activity]
GO:0042953 [lipoprotein transport]
GO:0043235 [receptor complex]
GO:0043277 [apoptotic cell clearance]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044877 [protein-containing complex binding]
GO:0045056 [transcytosis]
GO:0045202 [synapse]
GO:0045807 [positive regulation of endocytosis]
GO:0046872 [metal ion binding]
GO:0070325 [lipoprotein particle receptor binding]
GO:0097242 [amyloid-beta clearance]
GO:0098797 [plasma membrane protein complex]
GO:0150051 [postsynaptic Golgi apparatus]
GO:0150093 [amyloid-beta clearance by transcytosis]
GO:0150094 [amyloid-beta clearance by cellular catabolic process]
GO:0150104 [transport across blood-brain barrier]
GO:1900223 [positive regulation of amyloid-beta clearance]
GO:1903078 [positive regulation of protein localization to plasma membrane]
GO:1904300 [positive regulation of transcytosis]
GO:1904646 [cellular response to amyloid-beta]
GO:1905049 [negative regulation of metallopeptidase activity]
GO:1905167 [positive regulation of lysosomal protein catabolic process]
GO:2000587 [negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
Show all
292 aa
31.6 kDa
Yes 0
LRP1-204
ENSP00000451449
ENST00000553277
Q7Z7K9 [Direct mapping]
LRP1 protein; Prolow-density lipoprotein receptor-related protein 1
Show all
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
296 aa
32.2 kDa
Yes 0
LRP1-206
ENSP00000451622
ENST00000554118
H0YJI8 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
139 aa
15.4 kDa
No 0
LRP1-207
ENSP00000451737
ENST00000554174
Q6PJ72 [Direct mapping]
LRP1 protein; Prolow-density lipoprotein receptor-related protein 1
Show all
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006897 [endocytosis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
439 aa
48.2 kDa
Yes 0
LRP1-208
ENSP00000451012
ENST00000555124
H0YJ88 [Direct mapping]
Prolow-density lipoprotein receptor-related protein 1
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
183 aa
20.6 kDa
No 0

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