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AGO2
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  • AGO2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

AGO2
Synonyms CASC7, EIF2C2, hAGO2, LINC00980, Q10
Gene descriptioni

Full gene name according to HGNC.

Argonaute RISC catalytic component 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Enzymes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 8
Cytoband q24.3
Chromosome location (bp) 140520156 - 140635633
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000123908 (version 103.38)
Entrez gene 27161
HGNC HGNC:3263
UniProt Q9UKV8 (UniProt - Evidence at protein level)
neXtProt NX_Q9UKV8
Antibodypedia AGO2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 208

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
AGO2-201
AGO2-205
AGO2-210


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
AGO2-201
ENSP00000220592
ENST00000220592
Q9UKV8 [Direct mapping]
Protein argonaute-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000932 [P-body]
GO:0000993 [RNA polymerase II complex binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003729 [mRNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004521 [endoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0005845 [mRNA cap binding complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0008022 [protein C-terminus binding]
GO:0009791 [post-embryonic development]
GO:0010501 [RNA secondary structure unwinding]
GO:0010586 [miRNA metabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0016787 [hydrolase activity]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0030425 [dendrite]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035194 [post-transcriptional gene silencing by RNA]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035198 [miRNA binding]
GO:0035278 [miRNA mediated inhibition of translation]
GO:0035279 [mRNA cleavage involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045947 [negative regulation of translational initiation]
GO:0045975 [positive regulation of translation, ncRNA-mediated]
GO:0046872 [metal ion binding]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0060964 [regulation of gene silencing by miRNA]
GO:0070062 [extracellular exosome]
GO:0070551 [endoribonuclease activity, cleaving siRNA-paired mRNA]
GO:0070578 [RISC-loading complex]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:0090624 [endoribonuclease activity, cleaving miRNA-paired mRNA]
GO:0090625 [mRNA cleavage involved in gene silencing by siRNA]
GO:0098808 [mRNA cap binding]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1905618 [positive regulation of miRNA mediated inhibition of translation]
GO:1990904 [ribonucleoprotein complex]
Show all
859 aa
97.2 kDa
No 0
AGO2-205
ENSP00000430176
ENST00000519980
Q9UKV8 [Direct mapping]
Protein argonaute-2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000340 [RNA 7-methylguanosine cap binding]
GO:0000932 [P-body]
GO:0000993 [RNA polymerase II complex binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0004518 [nuclease activity]
GO:0004519 [endonuclease activity]
GO:0004521 [endoribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0005845 [mRNA cap binding complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0007223 [Wnt signaling pathway, calcium modulating pathway]
GO:0008022 [protein C-terminus binding]
GO:0010501 [RNA secondary structure unwinding]
GO:0010586 [miRNA metabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0016442 [RISC complex]
GO:0016787 [hydrolase activity]
GO:0016891 [endoribonuclease activity, producing 5'-phosphomonoesters]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031054 [pre-miRNA processing]
GO:0035087 [siRNA loading onto RISC involved in RNA interference]
GO:0035194 [post-transcriptional gene silencing by RNA]
GO:0035196 [production of miRNAs involved in gene silencing by miRNA]
GO:0035197 [siRNA binding]
GO:0035198 [miRNA binding]
GO:0035278 [miRNA mediated inhibition of translation]
GO:0035279 [mRNA cleavage involved in gene silencing by miRNA]
GO:0035280 [miRNA loading onto RISC involved in gene silencing by miRNA]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0045947 [negative regulation of translational initiation]
GO:0045975 [positive regulation of translation, ncRNA-mediated]
GO:0046872 [metal ion binding]
GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening]
GO:0060964 [regulation of gene silencing by miRNA]
GO:0070062 [extracellular exosome]
GO:0070551 [endoribonuclease activity, cleaving siRNA-paired mRNA]
GO:0070578 [RISC-loading complex]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:0090624 [endoribonuclease activity, cleaving miRNA-paired mRNA]
GO:0090625 [mRNA cleavage involved in gene silencing by siRNA]
GO:0098808 [mRNA cap binding]
GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:1901165 [positive regulation of trophoblast cell migration]
GO:1905618 [positive regulation of miRNA mediated inhibition of translation]
GO:1990904 [ribonucleoprotein complex]
Show all
825 aa
93.6 kDa
No 0
AGO2-210
ENSP00000431056
ENST00000524328
E5RJY2 [Direct mapping]
Protein argonaute-2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0031047 [gene silencing by RNA]
Show all
36 aa
4.5 kDa
No 0

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The Project

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The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.