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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
p21.2
Chromosome location (bp)
36676460 - 36687337
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
CDKN1A-201
CDKN1A-202
CDKN1A-203
CDKN1A-204
CDKN1A-208
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Human disease related genes Cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007507 [heart development] GO:0008285 [negative regulation of cell population proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0030332 [cyclin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0032991 [protein-containing complex] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0044877 [protein-containing complex binding] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0140311 [protein sequestering activity] GO:1902806 [regulation of cell cycle G1/S phase transition] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179 [negative regulation of cardiac muscle tissue regeneration] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Human disease related genes Cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007507 [heart development] GO:0008285 [negative regulation of cell population proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0030332 [cyclin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0032991 [protein-containing complex] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0044877 [protein-containing complex binding] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0140311 [protein sequestering activity] GO:1902806 [regulation of cell cycle G1/S phase transition] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179 [negative regulation of cardiac muscle tissue regeneration] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Human disease related genes Cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006606 [protein import into nucleus] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007507 [heart development] GO:0008285 [negative regulation of cell population proliferation] GO:0009411 [response to UV] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010165 [response to X-ray] GO:0010243 [response to organonitrogen compound] GO:0010629 [negative regulation of gene expression] GO:0010942 [positive regulation of cell death] GO:0014070 [response to organic cyclic compound] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0030332 [cyclin binding] GO:0030890 [positive regulation of B cell proliferation] GO:0031100 [animal organ regeneration] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0032991 [protein-containing complex] GO:0034198 [cellular response to amino acid starvation] GO:0034605 [cellular response to heat] GO:0042060 [wound healing] GO:0042246 [tissue regeneration] GO:0042326 [negative regulation of phosphorylation] GO:0042493 [response to drug] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0043066 [negative regulation of apoptotic process] GO:0043068 [positive regulation of programmed cell death] GO:0044877 [protein-containing complex binding] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045860 [positive regulation of protein kinase activity] GO:0046685 [response to arsenic-containing substance] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048471 [perinuclear region of cytoplasm] GO:0050821 [protein stabilization] GO:0051384 [response to glucocorticoid] GO:0051412 [response to corticosterone] GO:0051726 [regulation of cell cycle] GO:0055093 [response to hyperoxia] GO:0060574 [intestinal epithelial cell maturation] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071480 [cellular response to gamma radiation] GO:0071493 [cellular response to UV-B] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090399 [replicative senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0140311 [protein sequestering activity] GO:1902806 [regulation of cell cycle G1/S phase transition] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179 [negative regulation of cardiac muscle tissue regeneration] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000278 [regulation of DNA biosynthetic process] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Human disease related genes Cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007507 [heart development] GO:0008285 [negative regulation of cell population proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0030332 [cyclin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0032991 [protein-containing complex] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0044877 [protein-containing complex binding] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0140311 [protein sequestering activity] GO:1902806 [regulation of cell cycle G1/S phase transition] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179 [negative regulation of cardiac muscle tissue regeneration] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes Human disease related genes Cancers Cancers of the breast and female genital organs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000307 [cyclin-dependent protein kinase holoenzyme complex] GO:0004860 [protein kinase inhibitor activity] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006974 [cellular response to DNA damage stimulus] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007049 [cell cycle] GO:0007050 [cell cycle arrest] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007265 [Ras protein signal transduction] GO:0007346 [regulation of mitotic cell cycle] GO:0007507 [heart development] GO:0008285 [negative regulation of cell population proliferation] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016604 [nuclear body] GO:0019221 [cytokine-mediated signaling pathway] GO:0019901 [protein kinase binding] GO:0019912 [cyclin-dependent protein kinase activating kinase activity] GO:0030308 [negative regulation of cell growth] GO:0030332 [cyclin binding] GO:0031625 [ubiquitin protein ligase binding] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0032991 [protein-containing complex] GO:0034198 [cellular response to amino acid starvation] GO:0042326 [negative regulation of phosphorylation] GO:0044877 [protein-containing complex binding] GO:0045860 [positive regulation of protein kinase activity] GO:0046872 [metal ion binding] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050821 [protein stabilization] GO:0070557 [PCNA-p21 complex] GO:0071479 [cellular response to ionizing radiation] GO:0071493 [cellular response to UV-B] GO:0071850 [mitotic cell cycle arrest] GO:0072331 [signal transduction by p53 class mediator] GO:0090398 [cellular senescence] GO:0090400 [stress-induced premature senescence] GO:0097193 [intrinsic apoptotic signaling pathway] GO:0140311 [protein sequestering activity] GO:1902806 [regulation of cell cycle G1/S phase transition] GO:1904030 [negative regulation of cyclin-dependent protein kinase activity] GO:1904031 [positive regulation of cyclin-dependent protein kinase activity] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1905179 [negative regulation of cardiac muscle tissue regeneration] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] GO:2000279 [negative regulation of DNA biosynthetic process] GO:2000379 [positive regulation of reactive oxygen species metabolic process]
The Human Protein Atlas project is funded
