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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Candidate cardiovascular disease genes FDA approved drug targets Human disease related genes Plasma proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q14.1
Chromosome location (bp)
112829751 - 112836816
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
IL1B-201
IL1B-202
IL1B-203
IL1B-204
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Transporters Transporter channels and pores Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes FDA approved drug targets Biotech drugs Small molecule drugs Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000187 [activation of MAPK activity] GO:0001660 [fever generation] GO:0001934 [positive regulation of protein phosphorylation] GO:0002711 [positive regulation of T cell mediated immunity] GO:0005125 [cytokine activity] GO:0005149 [interleukin-1 receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0007566 [embryo implantation] GO:0008284 [positive regulation of cell population proliferation] GO:0008285 [negative regulation of cell population proliferation] GO:0010573 [vascular endothelial growth factor production] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010628 [positive regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010829 [negative regulation of glucose transmembrane transport] GO:0014805 [smooth muscle adaptation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019904 [protein domain specific binding] GO:0030213 [hyaluronan biosynthetic process] GO:0030335 [positive regulation of cell migration] GO:0030730 [sequestering of triglyceride] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031394 [positive regulation of prostaglandin biosynthetic process] GO:0031622 [positive regulation of fever generation] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032308 [positive regulation of prostaglandin secretion] GO:0032496 [response to lipopolysaccharide] GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032743 [positive regulation of interleukin-2 production] GO:0032755 [positive regulation of interleukin-6 production] GO:0032757 [positive regulation of interleukin-8 production] GO:0033092 [positive regulation of immature T cell proliferation in thymus] GO:0033129 [positive regulation of histone phosphorylation] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0035066 [positive regulation of histone acetylation] GO:0035505 [positive regulation of myosin light chain kinase activity] GO:0035690 [cellular response to drug] GO:0042102 [positive regulation of T cell proliferation] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043407 [negative regulation of MAP kinase activity] GO:0043491 [protein kinase B signaling] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045833 [negative regulation of lipid metabolic process] GO:0045840 [positive regulation of mitotic nuclear division] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045917 [positive regulation of complement activation] GO:0046330 [positive regulation of JNK cascade] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0046827 [positive regulation of protein export from nucleus] GO:0050729 [positive regulation of inflammatory response] GO:0050766 [positive regulation of phagocytosis] GO:0050767 [regulation of neurogenesis] GO:0050768 [negative regulation of neurogenesis] GO:0050796 [regulation of insulin secretion] GO:0050805 [negative regulation of synaptic transmission] GO:0050995 [negative regulation of lipid catabolic process] GO:0050996 [positive regulation of lipid catabolic process] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051044 [positive regulation of membrane protein ectodomain proteolysis] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051781 [positive regulation of cell division] GO:0060252 [positive regulation of glial cell proliferation] GO:0060355 [positive regulation of cell adhesion molecule production] GO:0060559 [positive regulation of calcidiol 1-monooxygenase activity] GO:0070164 [negative regulation of adiponectin secretion] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070487 [monocyte aggregation] GO:0070498 [interleukin-1-mediated signaling pathway] GO:0070555 [response to interleukin-1] GO:0071222 [cellular response to lipopolysaccharide] GO:0071260 [cellular response to mechanical stimulus] GO:0071310 [cellular response to organic substance] GO:0071407 [cellular response to organic cyclic compound] GO:0071639 [positive regulation of monocyte chemotactic protein-1 production] GO:0150078 [positive regulation of neuroinflammatory response] GO:1900745 [positive regulation of p38MAPK cascade] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:1902680 [positive regulation of RNA biosynthetic process] GO:1903140 [regulation of establishment of endothelial barrier] GO:1903597 [negative regulation of gap junction assembly] GO:2000556 [positive regulation of T-helper 1 cell cytokine production] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Allergies and autoimmune diseases Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)