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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q12
Chromosome location (bp)
39404285 - 39451272
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MED1-201
MED1-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q15648 [Direct mapping] Mediator of RNA polymerase II transcription subunit 1
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000151 [ubiquitin ligase complex] GO:0000785 [chromatin] GO:0000902 [cell morphogenesis] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001525 [angiogenesis] GO:0001701 [in utero embryonic development] GO:0001889 [liver development] GO:0001892 [embryonic placenta development] GO:0002088 [lens development in camera-type eye] GO:0002154 [thyroid hormone mediated signaling pathway] GO:0003222 [ventricular trabecula myocardium morphogenesis] GO:0003406 [retinal pigment epithelium development] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription coregulator activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006590 [thyroid hormone generation] GO:0006606 [protein import into nucleus] GO:0006702 [androgen biosynthetic process] GO:0007275 [multicellular organism development] GO:0007420 [brain development] GO:0007507 [heart development] GO:0007595 [lactation] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0009887 [animal organ morphogenesis] GO:0010628 [positive regulation of gene expression] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016567 [protein ubiquitination] GO:0016592 [mediator complex] GO:0016922 [nuclear receptor binding] GO:0019216 [regulation of lipid metabolic process] GO:0030216 [keratinocyte differentiation] GO:0030224 [monocyte differentiation] GO:0030331 [estrogen receptor binding] GO:0030374 [nuclear receptor transcription coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0031100 [animal organ regeneration] GO:0031490 [chromatin DNA binding] GO:0032993 [protein-DNA complex] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0033598 [mammary gland epithelial cell proliferation] GO:0035050 [embryonic heart tube development] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035162 [embryonic hemopoiesis] GO:0035257 [nuclear hormone receptor binding] GO:0035357 [peroxisome proliferator activated receptor signaling pathway] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0035855 [megakaryocyte development] GO:0042789 [mRNA transcription by RNA polymerase II] GO:0042809 [vitamin D receptor binding] GO:0042974 [retinoic acid receptor binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043010 [camera-type eye development] GO:0043066 [negative regulation of apoptotic process] GO:0044877 [protein-containing complex binding] GO:0045444 [fat cell differentiation] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045665 [negative regulation of neuron differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046966 [thyroid hormone receptor binding] GO:0048821 [erythrocyte development] GO:0048822 [enucleate erythrocyte development] GO:0050693 [LBD domain binding] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway] GO:0060744 [mammary gland branching involved in thelarche] GO:0060745 [mammary gland branching involved in pregnancy] GO:0060750 [epithelial cell proliferation involved in mammary gland duct elongation] GO:0061630 [ubiquitin protein ligase activity] GO:0070318 [positive regulation of G0 to G1 transition] GO:0070562 [regulation of vitamin D receptor signaling pathway] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071383 [cellular response to steroid hormone stimulus] GO:0097067 [cellular response to thyroid hormone stimulus] GO:1990841 [promoter-specific chromatin binding] GO:2000347 [positive regulation of hepatocyte proliferation] GO:2001141 [regulation of RNA biosynthetic process]
Q15648 [Direct mapping] Mediator of RNA polymerase II transcription subunit 1
Show all
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000902 [cell morphogenesis] GO:0001525 [angiogenesis] GO:0002088 [lens development in camera-type eye] GO:0002154 [thyroid hormone mediated signaling pathway] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003712 [transcription coregulator activity] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006702 [androgen biosynthetic process] GO:0008134 [transcription factor binding] GO:0010628 [positive regulation of gene expression] GO:0010839 [negative regulation of keratinocyte proliferation] GO:0016020 [membrane] GO:0016592 [mediator complex] GO:0016922 [nuclear receptor binding] GO:0019216 [regulation of lipid metabolic process] GO:0030216 [keratinocyte differentiation] GO:0030331 [estrogen receptor binding] GO:0030374 [nuclear receptor transcription coactivator activity] GO:0030518 [intracellular steroid hormone receptor signaling pathway] GO:0035257 [nuclear hormone receptor binding] GO:0035855 [megakaryocyte development] GO:0042789 [mRNA transcription by RNA polymerase II] GO:0042809 [vitamin D receptor binding] GO:0042974 [retinoic acid receptor binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0045444 [fat cell differentiation] GO:0045618 [positive regulation of keratinocyte differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045665 [negative regulation of neuron differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046966 [thyroid hormone receptor binding] GO:0048821 [erythrocyte development] GO:0050693 [LBD domain binding] GO:0060261 [positive regulation of transcription initiation from RNA polymerase II promoter] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071383 [cellular response to steroid hormone stimulus] GO:0097067 [cellular response to thyroid hormone stimulus] GO:2001141 [regulation of RNA biosynthetic process]