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BMP2
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  • BMP2
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

BMP2
Synonyms BMP2A
Gene descriptioni

Full gene name according to HGNC.

Bone morphogenetic protein 2
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Human disease related genes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 20
Cytoband p12.3
Chromosome location (bp) 6767686 - 6780246
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

1
Ensembl ENSG00000125845 (version 103.38)
Entrez gene 650
HGNC HGNC:1069
UniProt P12643 (UniProt - Evidence at protein level)
neXtProt NX_P12643
Antibodypedia BMP2 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 224

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
BMP2-201


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
BMP2-201
ENSP00000368104
ENST00000378827
P12643 [Direct mapping]
Bone morphogenetic protein 2
C8C060 [Target identity:100%; Query identity:100%]
Bone morphogenetic protein 2
Show all
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000187 [activation of MAPK activity]
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001649 [osteoblast differentiation]
GO:0001658 [branching involved in ureteric bud morphogenesis]
GO:0001666 [response to hypoxia]
GO:0001701 [in utero embryonic development]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002062 [chondrocyte differentiation]
GO:0003130 [BMP signaling pathway involved in heart induction]
GO:0003176 [aortic valve development]
GO:0003181 [atrioventricular valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003210 [cardiac atrium formation]
GO:0003272 [endocardial cushion formation]
GO:0003308 [negative regulation of Wnt signaling pathway involved in heart development]
GO:0003331 [positive regulation of extracellular matrix constituent secretion]
GO:0004745 [retinol dehydrogenase activity]
GO:0005102 [signaling receptor binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006029 [proteoglycan metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007275 [multicellular organism development]
GO:0007507 [heart development]
GO:0008083 [growth factor activity]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009617 [response to bacterium]
GO:0009887 [animal organ morphogenesis]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0010894 [negative regulation of steroid biosynthetic process]
GO:0010922 [positive regulation of phosphatase activity]
GO:0019211 [phosphatase activator activity]
GO:0021537 [telencephalon development]
GO:0021978 [telencephalon regionalization]
GO:0030154 [cell differentiation]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0030335 [positive regulation of cell migration]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0031648 [protein destabilization]
GO:0032092 [positive regulation of protein binding]
GO:0032348 [negative regulation of aldosterone biosynthetic process]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0035051 [cardiocyte differentiation]
GO:0035054 [embryonic heart tube anterior/posterior pattern specification]
GO:0035630 [bone mineralization involved in bone maturation]
GO:0039706 [co-receptor binding]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042482 [positive regulation of odontogenesis]
GO:0042487 [regulation of odontogenesis of dentin-containing tooth]
GO:0043065 [positive regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043569 [negative regulation of insulin-like growth factor receptor signaling pathway]
GO:0045165 [cell fate commitment]
GO:0045597 [positive regulation of cell differentiation]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045778 [positive regulation of ossification]
GO:0045786 [negative regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0048762 [mesenchymal cell differentiation]
GO:0048839 [inner ear development]
GO:0051042 [negative regulation of calcium-independent cell-cell adhesion]
GO:0051216 [cartilage development]
GO:0055007 [cardiac muscle cell differentiation]
GO:0055008 [cardiac muscle tissue morphogenesis]
GO:0055114 [oxidation-reduction process]
GO:0060039 [pericardium development]
GO:0060128 [corticotropin hormone secreting cell differentiation]
GO:0060129 [thyroid-stimulating hormone-secreting cell differentiation]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060395 [SMAD protein signal transduction]
GO:0060485 [mesenchyme development]
GO:0060804 [positive regulation of Wnt signaling pathway by BMP signaling pathway]
GO:0061036 [positive regulation of cartilage development]
GO:0061312 [BMP signaling pathway involved in heart development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070700 [BMP receptor binding]
GO:0070724 [BMP receptor complex]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071773 [cellular response to BMP stimulus]
GO:0072138 [mesenchymal cell proliferation involved in ureteric bud development]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1901522 [positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus]
GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II]
GO:1905072 [cardiac jelly development]
GO:1905222 [atrioventricular canal morphogenesis]
GO:2000065 [negative regulation of cortisol biosynthetic process]
GO:2000726 [negative regulation of cardiac muscle cell differentiation]
Show all
396 aa
44.7 kDa
Yes 0

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The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS

The Human Protein Atlas

  • DOWNLOADABLE DATA
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.