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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:58.6 nTPM
HPA:58.6 nTPM
GTEx:76.9 nTPM
FANTOM5:20.6 Scaled Tags Per Million
Pig:79.8 nTPM
Mouse:85.9 nTPM
Allen mouse:0.4 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 58.6
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 54.0
2411 Female, age 72, unknown 57.3
1870 Female, age 42, unknown 57.1
2019 Male, age 18, unknown 55.0
1833 Male, age 53, unknown 54.9
1827 Male, age 72, unknown 54.8
2219 Male, age 76, both hemispheres 53.5
1830 Male, age 51, unknown 53.3
2666 Male, age 74, left hemisphere 52.8
2828 Female, age 72, unknown 51.0
2586 Male, age 75, left hemisphere 50.6
Dorsal raphe nucleus
nTPM: 57.2
1828 Male, age 53, unknown 59.9
2298 Female, age 72, unknown 58.2
2047 Male, age 72, unknown 57.7
2016 Female, age 72, unknown 55.5
2750 Male, age 76, both hemispheres 54.6
Inferior colliculus
nTPM: 55.3
1848 Female, age 42, unknown 56.7
2097 Female, age 72, unknown 56.2
1890 Male, age 53, unknown 55.3
2849 Male, age 72, unknown 53.0
Median raphe nucleus
nTPM: 56.2
2220 Male, age 76, midline 56.2
Pedunculopontine tegmental nucleus
nTPM: 56.9
2334 Male, age 80, both hemispheres 59.4
1921 Female, age 85, both hemispheres 57.6
2338 Male, age 61, both hemispheres 53.7
Periaquaductal grey, anterior
nTPM: 55.7
1947 Male, age 18, unknown 57.8
2502 Female, age 75, unknown 56.0
1795 Male, age 51, unknown 53.4
Periaquaductal grey, dorsal
nTPM: 54.2
1840 Male, age 53, unknown 55.0
2850 Male, age 76, both hemispheres 54.7
1831 Male, age 72, unknown 54.0
2464 Female, age 72, unknown 53.2
Periaquaductal grey, lateral
nTPM: 54.2
2272 Male, age 74, both hemispheres 55.7
2053 Male, age 18, unknown 54.1
2140 Male, age 76, both hemispheres 52.7
Pretectal area
nTPM: 54.3
2224 Female, age 72, unknown 58.4
2273 Male, age 74, both hemispheres 55.8
2667 Female, age 75, unknown 55.6
2007 Male, age 72, unknown 55.1
1944 Female, age 72, unknown 54.8
1816 Male, age 51, unknown 54.3
2825 Male, age 18, unknown 53.9
1817 Female, age 42, unknown 53.8
1815 Male, age 53, unknown 52.9
2316 Male, age 76, right hemisphere 52.3
2407 Male, age 75, both hemispheres 50.0
Red nucleus
nTPM: 53.3
1821 Female, age 72, unknown 59.5
1954 Female, age 42, unknown 54.7
2823 Male, age 76, right hemisphere 53.8
2725 Female, age 75, unknown 53.7
2503 Female, age 72, unknown 53.0
1865 Male, age 51, unknown 52.9
1904 Male, age 53, unknown 52.8
2227 Male, age 72, unknown 52.7
2769 Male, age 72, unknown 52.6
2584 Male, age 75, left hemisphere 52.2
2785 Male, age 18, unknown 51.2
2588 Male, age 74, left hemisphere 50.6
Substantia nigra
nTPM: 58.6
2241 Male, age 72, unknown 65.5
1916 Female, age 42, unknown 64.2
1851 Male, age 51, unknown 61.4
2699 Male, age 18, unknown 59.3
1889 Female, age 72, unknown 57.5
2409 Female, age 72, unknown 57.1
1941 Male, age 53, unknown 56.6
2665 Male, age 74, both hemispheres 56.3
2590 Female, age 75, unknown 55.6
2583 Male, age 75, right hemisphere 52.6
Superior colliculus
nTPM: 52.8
1895 Male, age 76, right hemisphere 56.4
2587 Male, age 74, left hemisphere 55.7
1839 Male, age 51, unknown 54.1
1796 Male, age 53, unknown 52.9
2668 Female, age 75, unknown 52.8
2087 Female, age 72, unknown 52.2
2664 Male, age 75, both hemispheres 52.0
2261 Male, age 18, unknown 51.6
1913 Female, age 42, unknown 50.9
1995 Male, age 72, unknown 49.7
Ventral tegmental area
nTPM: 58.0
1915 Female, age 42, unknown 61.9
2410 Female, age 72, unknown 60.9
2218 Male, age 76, both hemispheres 57.8
1942 Male, age 51, unknown 56.9
2021 Male, age 53, unknown 56.3
2223 Female, age 72, unknown 54.1

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 76.9
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 76.9
Samples: 139

Max nTPM: 159.6
Min nTPM: 41.3
Std nTPM: 21.7
Median nTPM: 74.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 159.6
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 137.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 137.2
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 120.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 120.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 115.1
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 114.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 114.1
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 112.0
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 110.8
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 109.9
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 109.4
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 107.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 107.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 105.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 105.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 103.9
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 101.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 100.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 99.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 98.4
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 98.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 97.5
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 97.2
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 96.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 95.2
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 94.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 94.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 94.4
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 94.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 94.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 93.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 93.2
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 93.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 92.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 92.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 90.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 90.7
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 90.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 89.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 87.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 86.9
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 86.5
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 85.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 85.0
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 84.7
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 82.8
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 82.6
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 82.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 81.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 81.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 81.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 80.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 79.7
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 79.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 79.3
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 79.1
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 78.8
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 78.7
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 78.2
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 76.9
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 76.8
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 76.8
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 76.8
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 76.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 76.5
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 76.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 75.7
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 75.0
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 74.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 74.8
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 74.3
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 74.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 73.9
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 72.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 72.0
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 71.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 71.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 71.8
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 71.7
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 70.6
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 70.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 70.1
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 70.0
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 68.8
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 67.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 66.8
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 66.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 66.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 66.0
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 65.6
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 65.5
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 65.4
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 65.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 64.2
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 63.6
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 63.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 63.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 62.4
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 62.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 62.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 61.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 60.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 60.8
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 60.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 60.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 59.5
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 58.3
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 57.6
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 57.5
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 57.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 56.9
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 56.6
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 55.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 55.7
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 55.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 54.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 54.5
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 53.6
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 53.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 52.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 52.0
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 52.0
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 50.7
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 50.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 50.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 49.7
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 49.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 49.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 49.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 48.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 47.3
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 47.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 46.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 44.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 42.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 41.9
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 41.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 41.3
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 20.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 20.6
FF:10158-103A5 76 years, female 20.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 79.8
Pig sample Sample description nTPM
Midbrain
nTPM: 73.9
Samples: 4

Max nTPM: 91.0
Min nTPM: 59.2
Sample A Female 91.0
Sample B Female 85.7
Sample C Male 59.2
Sample D Male 59.5
Periaqueductal gray
nTPM: 72.7
Samples: 3

Max nTPM: 80.1
Min nTPM: 68.4
Sample B Female 69.6
Sample C Male 80.1
Sample D Male 68.4
Substantia nigra
nTPM: 73.8
Samples: 4

Max nTPM: 100.9
Min nTPM: 47.7
Sample A Female 100.9
Sample B Female 67.5
Sample C Male 79.0
Sample D Male 47.7
Superior colliculi
nTPM: 79.8
Samples: 4

Max nTPM: 97.3
Min nTPM: 68.5
Sample A Female 97.3
Sample B Female 69.9
Sample C Male 83.4
Sample D Male 68.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 85.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 85.9
Samples: 4

Max nTPM: 98.8
Min nTPM: 79.9
Sample A Male 98.8
Sample B Male 81.3
Sample C Female 79.9
Sample D Female 83.6

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.4
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.4
68744773 Antisense, RP_050208_01_F04, Mouse strain C57BL/6J (56 days, male) 0.4

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