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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
AND
VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:216.9 nTPM
HPA:216.9 nTPM
GTEx:230.7 nTPM
FANTOM5:182.4 Scaled Tags Per Million
Pig:58.1 nTPM
Mouse:46.3 nTPM
Allen mouse:0.6 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 216.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 195.6
2586 Male, age 75, left hemisphere 233.9
2666 Male, age 74, left hemisphere 221.7
1830 Male, age 51, unknown 201.7
2828 Female, age 72, unknown 197.9
1833 Male, age 53, unknown 197.8
1870 Female, age 42, unknown 192.5
2411 Female, age 72, unknown 187.0
2019 Male, age 18, unknown 185.4
1827 Male, age 72, unknown 172.6
2219 Male, age 76, both hemispheres 165.1
Dorsal raphe nucleus
nTPM: 173.0
2750 Male, age 76, both hemispheres 191.1
2016 Female, age 72, unknown 182.9
1828 Male, age 53, unknown 171.6
2047 Male, age 72, unknown 171.2
2298 Female, age 72, unknown 148.0
Inferior colliculus
nTPM: 171.4
2849 Male, age 72, unknown 181.4
1848 Female, age 42, unknown 178.0
1890 Male, age 53, unknown 173.0
2097 Female, age 72, unknown 153.1
Median raphe nucleus
nTPM: 151.8
2220 Male, age 76, midline 151.8
Pedunculopontine tegmental nucleus
nTPM: 172.4
2334 Male, age 80, both hemispheres 177.4
2338 Male, age 61, both hemispheres 176.7
1921 Female, age 85, both hemispheres 163.1
Periaquaductal grey, anterior
nTPM: 173.5
2502 Female, age 75, unknown 180.7
1947 Male, age 18, unknown 177.2
1795 Male, age 51, unknown 162.7
Periaquaductal grey, dorsal
nTPM: 161.1
2464 Female, age 72, unknown 173.6
1831 Male, age 72, unknown 159.2
2850 Male, age 76, both hemispheres 156.7
1840 Male, age 53, unknown 155.0
Periaquaductal grey, lateral
nTPM: 163.9
2053 Male, age 18, unknown 177.3
2272 Male, age 74, both hemispheres 158.2
2140 Male, age 76, both hemispheres 156.1
Pretectal area
nTPM: 166.5
2407 Male, age 75, both hemispheres 180.4
2316 Male, age 76, right hemisphere 179.4
1815 Male, age 53, unknown 178.6
1817 Female, age 42, unknown 178.1
2825 Male, age 18, unknown 174.2
2007 Male, age 72, unknown 172.4
1944 Female, age 72, unknown 156.4
2667 Female, age 75, unknown 156.0
1816 Male, age 51, unknown 155.3
2224 Female, age 72, unknown 151.4
2273 Male, age 74, both hemispheres 149.5
Red nucleus
nTPM: 216.9
2588 Male, age 74, left hemisphere 260.7
1865 Male, age 51, unknown 228.5
1904 Male, age 53, unknown 227.4
2503 Female, age 72, unknown 226.0
2227 Male, age 72, unknown 221.9
2769 Male, age 72, unknown 219.4
1954 Female, age 42, unknown 207.0
1821 Female, age 72, unknown 206.3
2584 Male, age 75, left hemisphere 204.4
2823 Male, age 76, right hemisphere 204.1
2725 Female, age 75, unknown 201.5
2785 Male, age 18, unknown 195.5
Substantia nigra
nTPM: 177.5
2665 Male, age 74, both hemispheres 198.1
2590 Female, age 75, unknown 188.9
2583 Male, age 75, right hemisphere 187.0
1851 Male, age 51, unknown 180.6
2699 Male, age 18, unknown 178.9
1889 Female, age 72, unknown 176.6
2409 Female, age 72, unknown 174.8
1941 Male, age 53, unknown 171.5
1916 Female, age 42, unknown 161.2
2241 Male, age 72, unknown 157.1
Superior colliculus
nTPM: 182.8
1995 Male, age 72, unknown 204.2
2587 Male, age 74, left hemisphere 196.4
2664 Male, age 75, both hemispheres 191.9
1839 Male, age 51, unknown 188.6
2668 Female, age 75, unknown 184.6
1913 Female, age 42, unknown 181.8
1895 Male, age 76, right hemisphere 180.5
1796 Male, age 53, unknown 171.1
2261 Male, age 18, unknown 170.9
2087 Female, age 72, unknown 158.3
Ventral tegmental area
nTPM: 172.9
2410 Female, age 72, unknown 186.9
2223 Female, age 72, unknown 184.1
1942 Male, age 51, unknown 172.6
1915 Female, age 42, unknown 169.5
2021 Male, age 53, unknown 167.8
2218 Male, age 76, both hemispheres 156.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 230.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 230.7
Samples: 139

Max nTPM: 753.5
Min nTPM: 54.2
Std nTPM: 129.9
Median nTPM: 189.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 753.5
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 703.6
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 687.4
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 629.4
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 499.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 482.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 467.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 463.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 460.4
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 438.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 433.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 431.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 426.6
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 414.8
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 382.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 376.6
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 375.3
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 363.1
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 347.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 342.1
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 340.8
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 337.5
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 336.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 334.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 333.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 330.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 326.5
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 325.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 323.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 320.8
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 318.3
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 318.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 316.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 310.5
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 308.5
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 301.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 295.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 294.3
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 288.1
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 287.6
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 284.9
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 280.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 279.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 269.6
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 266.9
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 260.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 260.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 249.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 245.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 244.1
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 242.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 240.1
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 232.7
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 225.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 224.5
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 216.3
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 215.3
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 214.7
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 210.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 208.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 203.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 203.3
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 201.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 201.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 200.7
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 200.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 199.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 196.6
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 195.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 189.3
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 189.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 188.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 185.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 184.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 183.1
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 176.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 174.3
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 173.5
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 170.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 170.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 169.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 168.2
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 168.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 167.6
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 166.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 166.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 165.6
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 163.7
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 160.6
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 159.2
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 158.4
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 158.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 155.6
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 154.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 154.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 152.6
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 148.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 148.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 148.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 145.1
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 144.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 143.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 142.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 142.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 139.1
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 138.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 137.7
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 137.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 137.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 137.4
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 136.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 134.7
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 131.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 128.9
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 128.3
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 127.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 123.6
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 122.3
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 120.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 117.6
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 116.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 115.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 111.9
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 108.3
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 105.6
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 105.2
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 102.8
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 100.4
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 97.3
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 96.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 96.3
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 95.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 91.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 84.6
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 80.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 58.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 58.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 57.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 54.2
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 182.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 182.4
FF:10158-103A5 76 years, female 182.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 58.1
Pig sample Sample description nTPM
Midbrain
nTPM: 58.1
Samples: 4

Max nTPM: 125.4
Min nTPM: 28.3
Sample A Female 125.4
Sample B Female 46.4
Sample C Male 28.3
Sample D Male 32.2
Periaqueductal gray
nTPM: 32.6
Samples: 3

Max nTPM: 35.8
Min nTPM: 28.7
Sample B Female 35.8
Sample C Male 28.7
Sample D Male 33.4
Substantia nigra
nTPM: 50.0
Samples: 4

Max nTPM: 70.5
Min nTPM: 38.3
Sample A Female 50.4
Sample B Female 38.3
Sample C Male 40.9
Sample D Male 70.5
Superior colliculi
nTPM: 43.3
Samples: 4

Max nTPM: 51.6
Min nTPM: 38.0
Sample A Female 44.9
Sample B Female 38.6
Sample C Male 38.0
Sample D Male 51.6

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 46.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 46.3
Samples: 4

Max nTPM: 52.7
Min nTPM: 39.8
Sample A Male 52.7
Sample B Male 46.2
Sample C Female 39.8
Sample D Female 46.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.6
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.6
69735765 Antisense, RP_050503_03_E03, Mouse strain C57BL/6J (56 days, male) 0.6

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