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PRKAA1
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  • PRKAA1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

PRKAA1
Synonyms AMPKa1
Gene descriptioni

Full gene name according to HGNC.

Protein kinase AMP-activated catalytic subunit alpha 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Enzymes
FDA approved drug targets
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 5
Cytoband p13.1
Chromosome location (bp) 40759379 - 40798374
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

3
Ensembl ENSG00000132356 (version 103.38)
Entrez gene 5562
HGNC HGNC:9376
UniProt Q13131 (UniProt - Evidence at protein level)
neXtProt NX_Q13131
Antibodypedia PRKAA1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 0      # Population variants: 211

Antigens:

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On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PRKAA1-201
PRKAA1-202
PRKAA1-204


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
PRKAA1-201
ENSP00000296800
ENST00000296800
Q96E92 [Direct mapping]
5'-AMP-activated protein kinase catalytic subunit alpha-1; PRKAA1 protein; Protein kinase, AMP-activated, alpha 1 catalytic subunit, isoform CRA_b
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
Show all
207 aa
23.6 kDa
No 0
PRKAA1-202
ENSP00000346148
ENST00000354209
Q13131 [Direct mapping]
5'-AMP-activated protein kinase catalytic subunit alpha-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0001666 [response to hypoxia]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004679 [AMP-activated protein kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006006 [glucose metabolic process]
GO:0006325 [chromatin organization]
GO:0006468 [protein phosphorylation]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006694 [steroid biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006914 [autophagy]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008610 [lipid biosynthetic process]
GO:0009411 [response to UV]
GO:0009631 [cold acclimation]
GO:0010332 [response to gamma radiation]
GO:0010468 [regulation of gene expression]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0014823 [response to activity]
GO:0015721 [bile acid and bile salt transport]
GO:0016055 [Wnt signaling pathway]
GO:0016126 [sterol biosynthetic process]
GO:0016236 [macroautophagy]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016324 [apical plasma membrane]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0019395 [fatty acid oxidation]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031000 [response to caffeine]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031669 [cellular response to nutrient levels]
GO:0032007 [negative regulation of TOR signaling]
GO:0032991 [protein-containing complex]
GO:0033135 [regulation of peptidyl-serine phosphorylation]
GO:0034599 [cellular response to oxidative stress]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035690 [cellular response to drug]
GO:0038183 [bile acid signaling pathway]
GO:0042149 [cellular response to glucose starvation]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0044877 [protein-containing complex binding]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0046318 [negative regulation of glucosylceramide biosynthetic process]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0047322 [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity]
GO:0048156 [tau protein binding]
GO:0048511 [rhythmic process]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0050321 [tau-protein kinase activity]
GO:0050405 [[acetyl-CoA carboxylase] kinase activity]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0055089 [fatty acid homeostasis]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0061744 [motor behavior]
GO:0061762 [CAMKK-AMPK signaling cascade]
GO:0062028 [regulation of stress granule assembly]
GO:0070050 [neuron cellular homeostasis]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071277 [cellular response to calcium ion]
GO:0071333 [cellular response to glucose stimulus]
GO:0071361 [cellular response to ethanol]
GO:0071380 [cellular response to prostaglandin E stimulus]
GO:0071417 [cellular response to organonitrogen compound]
GO:0071456 [cellular response to hypoxia]
GO:0097009 [energy homeostasis]
GO:0106310 []
GO:0106311 []
GO:0120188 [regulation of bile acid secretion]
GO:1901563 [response to camptothecin]
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1903109 [positive regulation of mitochondrial transcription]
GO:1903829 [positive regulation of cellular protein localization]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1904486 [response to 17alpha-ethynylestradiol]
GO:2000758 [positive regulation of peptidyl-lysine acetylation]
Show all
574 aa
65.5 kDa
No 0
PRKAA1-204
ENSP00000380317
ENST00000397128
Q13131 [Direct mapping]
5'-AMP-activated protein kinase catalytic subunit alpha-1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
FDA approved drug targets
   Small molecule drugs
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000187 [activation of MAPK activity]
GO:0001666 [response to hypoxia]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004679 [AMP-activated protein kinase activity]
GO:0004691 [cAMP-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006468 [protein phosphorylation]
GO:0006629 [lipid metabolic process]
GO:0006631 [fatty acid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0006694 [steroid biosynthetic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006914 [autophagy]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0008202 [steroid metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0010332 [response to gamma radiation]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016055 [Wnt signaling pathway]
GO:0016126 [sterol biosynthetic process]
GO:0016236 [macroautophagy]
GO:0016241 [regulation of macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016607 [nuclear speck]
GO:0016740 [transferase activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031669 [cellular response to nutrient levels]
GO:0032007 [negative regulation of TOR signaling]
GO:0034599 [cellular response to oxidative stress]
GO:0035174 [histone serine kinase activity]
GO:0035404 [histone-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0042149 [cellular response to glucose starvation]
GO:0042593 [glucose homeostasis]
GO:0042752 [regulation of circadian rhythm]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0046318 [negative regulation of glucosylceramide biosynthetic process]
GO:0046872 [metal ion binding]
GO:0047322 [[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity]
GO:0048156 [tau protein binding]
GO:0048511 [rhythmic process]
GO:0050321 [tau-protein kinase activity]
GO:0050405 [[acetyl-CoA carboxylase] kinase activity]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0055089 [fatty acid homeostasis]
GO:0061744 [motor behavior]
GO:0061762 [CAMKK-AMPK signaling cascade]
GO:0070050 [neuron cellular homeostasis]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071277 [cellular response to calcium ion]
GO:0071333 [cellular response to glucose stimulus]
GO:0097009 [energy homeostasis]
GO:0106310 []
GO:0106311 []
GO:1901796 [regulation of signal transduction by p53 class mediator]
GO:1903829 [positive regulation of cellular protein localization]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:2000758 [positive regulation of peptidyl-lysine acetylation]
Show all
559 aa
64 kDa
No 0

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  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
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  • PUBLICATIONS

The Human Protein Atlas

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  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.