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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:316.2 nTPM
HPA:316.2 nTPM
GTEx:270.7 nTPM
FANTOM5:387.2 Scaled Tags Per Million
Pig:90.5 nTPM
Mouse:69.7 nTPM
Allen mouse:7.0 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 316.2
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 250.0
2828 Female, age 72, unknown 371.9
2586 Male, age 75, left hemisphere 360.6
2219 Male, age 76, both hemispheres 308.8
2666 Male, age 74, left hemisphere 284.6
1827 Male, age 72, unknown 229.7
1833 Male, age 53, unknown 207.8
1870 Female, age 42, unknown 205.7
1830 Male, age 51, unknown 190.9
2019 Male, age 18, unknown 185.0
2411 Female, age 72, unknown 154.8
Dorsal raphe nucleus
nTPM: 241.7
2016 Female, age 72, unknown 313.0
1828 Male, age 53, unknown 274.4
2047 Male, age 72, unknown 239.6
2298 Female, age 72, unknown 198.9
2750 Male, age 76, both hemispheres 182.7
Inferior colliculus
nTPM: 219.0
2849 Male, age 72, unknown 272.4
1848 Female, age 42, unknown 226.8
1890 Male, age 53, unknown 214.7
2097 Female, age 72, unknown 162.2
Median raphe nucleus
nTPM: 188.7
2220 Male, age 76, midline 188.7
Pedunculopontine tegmental nucleus
nTPM: 192.3
2334 Male, age 80, both hemispheres 221.3
1921 Female, age 85, both hemispheres 199.0
2338 Male, age 61, both hemispheres 156.7
Periaquaductal grey, anterior
nTPM: 264.3
1795 Male, age 51, unknown 327.4
2502 Female, age 75, unknown 275.7
1947 Male, age 18, unknown 189.6
Periaquaductal grey, dorsal
nTPM: 299.6
2850 Male, age 76, both hemispheres 381.9
1831 Male, age 72, unknown 325.9
1840 Male, age 53, unknown 283.7
2464 Female, age 72, unknown 206.7
Periaquaductal grey, lateral
nTPM: 316.2
2053 Male, age 18, unknown 356.7
2140 Male, age 76, both hemispheres 343.2
2272 Male, age 74, both hemispheres 248.7
Pretectal area
nTPM: 270.2
2407 Male, age 75, both hemispheres 314.1
2316 Male, age 76, right hemisphere 306.1
2825 Male, age 18, unknown 291.1
2667 Female, age 75, unknown 288.1
1944 Female, age 72, unknown 274.2
1815 Male, age 53, unknown 273.1
1816 Male, age 51, unknown 262.6
2273 Male, age 74, both hemispheres 261.1
2224 Female, age 72, unknown 248.5
1817 Female, age 42, unknown 236.9
2007 Male, age 72, unknown 216.7
Red nucleus
nTPM: 232.5
2503 Female, age 72, unknown 262.6
2769 Male, age 72, unknown 261.5
2584 Male, age 75, left hemisphere 247.7
2823 Male, age 76, right hemisphere 240.6
2588 Male, age 74, left hemisphere 239.9
2227 Male, age 72, unknown 238.8
1904 Male, age 53, unknown 233.8
1865 Male, age 51, unknown 230.2
2785 Male, age 18, unknown 222.3
1954 Female, age 42, unknown 210.7
2725 Female, age 75, unknown 206.7
1821 Female, age 72, unknown 195.1
Substantia nigra
nTPM: 249.3
2699 Male, age 18, unknown 417.0
2665 Male, age 74, both hemispheres 323.0
2583 Male, age 75, right hemisphere 297.3
1916 Female, age 42, unknown 244.6
1851 Male, age 51, unknown 241.1
2590 Female, age 75, unknown 223.4
1889 Female, age 72, unknown 211.3
1941 Male, age 53, unknown 204.5
2409 Female, age 72, unknown 182.1
2241 Male, age 72, unknown 148.6
Superior colliculus
nTPM: 275.4
2664 Male, age 75, both hemispheres 398.7
1995 Male, age 72, unknown 337.1
1913 Female, age 42, unknown 296.0
2668 Female, age 75, unknown 281.8
1796 Male, age 53, unknown 276.5
2587 Male, age 74, left hemisphere 260.8
2087 Female, age 72, unknown 258.2
1839 Male, age 51, unknown 257.5
2261 Male, age 18, unknown 227.9
1895 Male, age 76, right hemisphere 159.2
Ventral tegmental area
nTPM: 243.2
2021 Male, age 53, unknown 278.5
1942 Male, age 51, unknown 256.4
1915 Female, age 42, unknown 246.7
2218 Male, age 76, both hemispheres 231.5
2223 Female, age 72, unknown 229.2
2410 Female, age 72, unknown 216.9

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 270.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 270.7
Samples: 139

Max nTPM: 494.1
Min nTPM: 71.0
Std nTPM: 91.9
Median nTPM: 260.0
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 494.1
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 489.8
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 484.7
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 484.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 447.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 435.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 434.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 428.6
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 427.4
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 425.9
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 417.4
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 416.0
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 412.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 405.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 398.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 398.2
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 396.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 392.6
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 386.6
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 386.5
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 378.3
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 378.2
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 371.2
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 361.5
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 356.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 354.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 352.6
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 349.8
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 346.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 344.7
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 344.4
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 342.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 340.2
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 338.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 337.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 336.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 336.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 333.8
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 331.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 330.8
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 324.8
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 323.2
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 318.2
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 308.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 308.7
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 308.4
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 308.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 305.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 297.2
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 296.6
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 293.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 286.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 284.8
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 281.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 278.8
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 277.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 277.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 276.1
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 275.5
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 273.0
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 272.5
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 269.8
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 265.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 264.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 264.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 264.0
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 261.4
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 261.1
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 260.4
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 260.0
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 258.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 256.5
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 254.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 253.1
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 252.2
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 251.4
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 247.2
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 244.4
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 244.0
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 241.6
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 241.3
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 241.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 238.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 237.9
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 236.8
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 235.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 234.3
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 232.9
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 232.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 230.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 229.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 228.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 223.4
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 220.6
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 218.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 217.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 217.1
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 215.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 214.7
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 211.2
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 208.7
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 206.3
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 206.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 206.2
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 201.2
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 197.6
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 194.5
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 193.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 192.9
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 190.1
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 188.1
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 187.4
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 186.9
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 185.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 183.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 183.0
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 182.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 181.7
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 180.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 179.2
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 176.1
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 174.9
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 171.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 171.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 168.7
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 167.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 164.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 161.8
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 150.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 145.8
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 140.6
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 139.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 117.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 117.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 115.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 110.4
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 108.5
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 85.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 71.0
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 387.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 387.2
FF:10158-103A5 76 years, female 387.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 90.5
Pig sample Sample description nTPM
Midbrain
nTPM: 85.6
Samples: 4

Max nTPM: 90.5
Min nTPM: 81.5
Sample A Female 81.5
Sample B Female 85.6
Sample C Male 90.5
Sample D Male 84.9
Periaqueductal gray
nTPM: 87.3
Samples: 3

Max nTPM: 92.7
Min nTPM: 80.5
Sample B Female 88.7
Sample C Male 92.7
Sample D Male 80.5
Substantia nigra
nTPM: 90.5
Samples: 4

Max nTPM: 100.7
Min nTPM: 73.3
Sample A Female 88.2
Sample B Female 73.3
Sample C Male 100.7
Sample D Male 99.7
Superior colliculi
nTPM: 80.9
Samples: 4

Max nTPM: 98.5
Min nTPM: 48.8
Sample A Female 89.5
Sample B Female 48.8
Sample C Male 86.8
Sample D Male 98.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 69.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 69.7
Samples: 4

Max nTPM: 81.0
Min nTPM: 63.9
Sample A Male 81.0
Sample B Male 64.0
Sample C Female 63.9
Sample D Female 70.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 7.0
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 7.0
69816494 Antisense, RP_050510_01_C01, Mouse strain C57BL/6J (56 days, male) 7.1
77332715 Antisense, RP_070116_02_B11, Mouse strain C57BL/6J (56 days, male) 6.9

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