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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:112.8 nTPM
HPA:112.8 nTPM
GTEx:210.1 nTPM
FANTOM5:203.4 Scaled Tags Per Million
Pig:0.5 nTPM
Mouse:25.8 nTPM
Allen mouse:0.1 Expression energy

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 112.8
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 76.5
2586 Male, age 75, left hemisphere 167.3
2019 Male, age 18, unknown 83.7
2828 Female, age 72, unknown 81.7
2666 Male, age 74, left hemisphere 73.3
1833 Male, age 53, unknown 63.8
1870 Female, age 42, unknown 63.1
1827 Male, age 72, unknown 62.4
1830 Male, age 51, unknown 61.0
2411 Female, age 72, unknown 56.3
2219 Male, age 76, both hemispheres 52.8
Dorsal raphe nucleus
nTPM: 87.0
2047 Male, age 72, unknown 138.4
1828 Male, age 53, unknown 99.8
2016 Female, age 72, unknown 70.2
2750 Male, age 76, both hemispheres 67.2
2298 Female, age 72, unknown 59.3
Inferior colliculus
nTPM: 112.8
2097 Female, age 72, unknown 150.2
1890 Male, age 53, unknown 140.7
2849 Male, age 72, unknown 83.5
1848 Female, age 42, unknown 76.8
Median raphe nucleus
nTPM: 88.7
2220 Male, age 76, midline 88.7
Pedunculopontine tegmental nucleus
nTPM: 94.3
2338 Male, age 61, both hemispheres 149.8
2334 Male, age 80, both hemispheres 81.3
1921 Female, age 85, both hemispheres 51.8
Periaquaductal grey, anterior
nTPM: 68.7
2502 Female, age 75, unknown 79.4
1795 Male, age 51, unknown 69.1
1947 Male, age 18, unknown 57.5
Periaquaductal grey, dorsal
nTPM: 69.8
2850 Male, age 76, both hemispheres 94.7
2464 Female, age 72, unknown 69.1
1840 Male, age 53, unknown 60.8
1831 Male, age 72, unknown 54.6
Periaquaductal grey, lateral
nTPM: 67.0
2140 Male, age 76, both hemispheres 77.5
2053 Male, age 18, unknown 71.7
2272 Male, age 74, both hemispheres 51.9
Pretectal area
nTPM: 57.7
1817 Female, age 42, unknown 82.0
2667 Female, age 75, unknown 66.3
2825 Male, age 18, unknown 58.8
1944 Female, age 72, unknown 58.3
2407 Male, age 75, both hemispheres 58.3
2007 Male, age 72, unknown 56.6
1816 Male, age 51, unknown 54.4
2316 Male, age 76, right hemisphere 52.8
2224 Female, age 72, unknown 52.0
1815 Male, age 53, unknown 47.9
2273 Male, age 74, both hemispheres 46.9
Red nucleus
nTPM: 88.1
2725 Female, age 75, unknown 127.6
2823 Male, age 76, right hemisphere 98.6
1821 Female, age 72, unknown 96.1
2769 Male, age 72, unknown 95.8
2584 Male, age 75, left hemisphere 95.7
2227 Male, age 72, unknown 91.7
2785 Male, age 18, unknown 81.7
1954 Female, age 42, unknown 81.4
2503 Female, age 72, unknown 78.7
1865 Male, age 51, unknown 76.3
2588 Male, age 74, left hemisphere 68.1
1904 Male, age 53, unknown 65.4
Substantia nigra
nTPM: 77.4
1941 Male, age 53, unknown 105.9
2409 Female, age 72, unknown 105.5
1851 Male, age 51, unknown 97.4
1916 Female, age 42, unknown 83.8
1889 Female, age 72, unknown 73.3
2699 Male, age 18, unknown 70.5
2241 Male, age 72, unknown 68.3
2583 Male, age 75, right hemisphere 62.7
2590 Female, age 75, unknown 57.0
2665 Male, age 74, both hemispheres 50.0
Superior colliculus
nTPM: 56.1
1913 Female, age 42, unknown 63.4
1839 Male, age 51, unknown 62.7
1796 Male, age 53, unknown 59.9
1895 Male, age 76, right hemisphere 58.6
2087 Female, age 72, unknown 57.5
1995 Male, age 72, unknown 57.3
2664 Male, age 75, both hemispheres 54.6
2261 Male, age 18, unknown 52.8
2587 Male, age 74, left hemisphere 50.6
2668 Female, age 75, unknown 43.9
Ventral tegmental area
nTPM: 77.6
1915 Female, age 42, unknown 123.8
2223 Female, age 72, unknown 74.9
2218 Male, age 76, both hemispheres 68.4
2410 Female, age 72, unknown 66.9
2021 Male, age 53, unknown 66.5
1942 Male, age 51, unknown 65.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 210.1
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 210.1
Samples: 139

Max nTPM: 3474.6
Min nTPM: 9.1
Std nTPM: 454.4
Median nTPM: 86.6
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 3474.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2721.0
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 2120.8
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 1769.7
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 1308.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1161.5
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 821.0
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 750.0
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 665.6
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 548.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 515.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 512.9
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 502.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 377.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 368.7
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 346.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 309.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 294.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 289.5
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 279.0
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 248.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 246.6
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 233.2
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 223.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 196.3
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 191.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 187.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 175.8
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 169.7
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 161.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 158.8
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 158.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 156.8
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 152.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 143.6
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 142.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 139.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 134.3
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 134.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 129.3
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 127.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 127.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 126.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 124.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 120.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 119.0
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 118.0
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 115.9
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 112.7
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 110.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 109.5
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 104.1
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 103.2
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 101.6
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 101.5
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 101.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 99.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 99.5
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 97.0
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 94.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 90.9
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 90.8
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 89.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 89.0
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 88.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 88.5
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 88.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 87.9
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 87.7
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 86.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 85.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 84.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 84.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 83.0
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 82.5
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 80.7
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 79.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 78.4
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 77.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 77.5
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 73.9
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 73.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 73.8
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 71.8
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 70.9
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 70.3
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 69.9
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 67.8
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 67.7
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 66.1
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 65.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 64.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 64.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 63.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 62.6
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 61.9
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 61.1
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 59.3
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 58.2
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 58.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 53.8
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 52.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 51.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 51.0
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 50.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 50.7
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 50.0
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 49.7
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 45.3
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 45.3
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 43.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 43.3
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 43.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 42.5
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 37.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 36.8
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 36.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 36.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 35.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 35.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 35.5
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 34.7
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 34.6
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 31.5
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 31.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 29.9
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 28.9
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 28.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 26.3
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 26.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 25.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 22.8
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 18.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 18.1
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 16.8
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 11.4
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 11.2
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 9.9
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 9.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 203.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 203.4
FF:10158-103A5 76 years, female 203.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 0.5
Pig sample Sample description nTPM
Midbrain
nTPM: 0.3
Samples: 4

Max nTPM: 0.5
Min nTPM: 0.2
Sample A Female 0.2
Sample B Female 0.5
Sample C Male 0.2
Sample D Male 0.3
Periaqueductal gray
nTPM: 0.2
Samples: 3

Max nTPM: 0.3
Min nTPM: 0.1
Sample B Female 0.1
Sample C Male 0.3
Sample D Male 0.2
Substantia nigra
nTPM: 0.5
Samples: 4

Max nTPM: 0.7
Min nTPM: 0.4
Sample A Female 0.4
Sample B Female 0.4
Sample C Male 0.5
Sample D Male 0.7
Superior colliculi
nTPM: 0.3
Samples: 4

Max nTPM: 0.5
Min nTPM: 0.1
Sample A Female 0.5
Sample B Female 0.1
Sample C Male 0.2
Sample D Male 0.2

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 25.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 25.8
Samples: 4

Max nTPM: 27.4
Min nTPM: 24.2
Sample A Male 25.5
Sample B Male 27.4
Sample C Female 24.2
Sample D Female 26.0

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 0.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 0.1
68443232 Antisense, RP_050111_01_F02, Mouse strain C57BL/6J (56 days, male) 0.1

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