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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:74.1 nTPM
HPA:74.1 nTPM
GTEx:107.0 nTPM
FANTOM5:102.2 Scaled Tags Per Million
Pig:30.3 nTPM
Mouse:23.7 nTPM
Allen mouse:3.1 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 74.1
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 68.8
2666 Male, age 74, left hemisphere 92.1
2586 Male, age 75, left hemisphere 87.2
2828 Female, age 72, unknown 71.5
1827 Male, age 72, unknown 70.2
2019 Male, age 18, unknown 65.4
2411 Female, age 72, unknown 63.1
2219 Male, age 76, both hemispheres 62.6
1870 Female, age 42, unknown 60.1
1833 Male, age 53, unknown 58.8
1830 Male, age 51, unknown 57.2
Dorsal raphe nucleus
nTPM: 56.3
2750 Male, age 76, both hemispheres 62.9
2047 Male, age 72, unknown 58.0
2298 Female, age 72, unknown 57.1
1828 Male, age 53, unknown 55.3
2016 Female, age 72, unknown 48.4
Inferior colliculus
nTPM: 64.4
2849 Male, age 72, unknown 71.2
2097 Female, age 72, unknown 66.5
1848 Female, age 42, unknown 60.8
1890 Male, age 53, unknown 59.0
Median raphe nucleus
nTPM: 63.5
2220 Male, age 76, midline 63.5
Pedunculopontine tegmental nucleus
nTPM: 57.9
1921 Female, age 85, both hemispheres 65.4
2334 Male, age 80, both hemispheres 63.2
2338 Male, age 61, both hemispheres 45.0
Periaquaductal grey, anterior
nTPM: 74.1
2502 Female, age 75, unknown 77.2
1795 Male, age 51, unknown 75.5
1947 Male, age 18, unknown 69.6
Periaquaductal grey, dorsal
nTPM: 56.5
1840 Male, age 53, unknown 65.4
2464 Female, age 72, unknown 61.2
1831 Male, age 72, unknown 51.9
2850 Male, age 76, both hemispheres 47.6
Periaquaductal grey, lateral
nTPM: 49.4
2053 Male, age 18, unknown 54.0
2140 Male, age 76, both hemispheres 49.9
2272 Male, age 74, both hemispheres 44.3
Pretectal area
nTPM: 69.0
1816 Male, age 51, unknown 94.3
2007 Male, age 72, unknown 86.2
1817 Female, age 42, unknown 84.9
1944 Female, age 72, unknown 81.7
1815 Male, age 53, unknown 69.9
2825 Male, age 18, unknown 64.6
2667 Female, age 75, unknown 62.9
2224 Female, age 72, unknown 60.4
2316 Male, age 76, right hemisphere 58.0
2407 Male, age 75, both hemispheres 56.8
2273 Male, age 74, both hemispheres 39.4
Red nucleus
nTPM: 57.4
2584 Male, age 75, left hemisphere 80.1
2785 Male, age 18, unknown 71.4
2588 Male, age 74, left hemisphere 69.7
2227 Male, age 72, unknown 59.4
2769 Male, age 72, unknown 58.6
2503 Female, age 72, unknown 55.4
2823 Male, age 76, right hemisphere 52.2
1954 Female, age 42, unknown 51.9
1904 Male, age 53, unknown 48.2
2725 Female, age 75, unknown 48.0
1821 Female, age 72, unknown 46.9
1865 Male, age 51, unknown 46.9
Substantia nigra
nTPM: 61.7
2665 Male, age 74, both hemispheres 78.2
1889 Female, age 72, unknown 74.8
1941 Male, age 53, unknown 73.3
1916 Female, age 42, unknown 68.1
2583 Male, age 75, right hemisphere 64.3
1851 Male, age 51, unknown 63.2
2590 Female, age 75, unknown 51.2
2699 Male, age 18, unknown 50.6
2241 Male, age 72, unknown 48.5
2409 Female, age 72, unknown 44.6
Superior colliculus
nTPM: 68.8
2668 Female, age 75, unknown 97.2
2087 Female, age 72, unknown 76.2
2664 Male, age 75, both hemispheres 73.9
1796 Male, age 53, unknown 71.1
2261 Male, age 18, unknown 67.3
1839 Male, age 51, unknown 65.7
1895 Male, age 76, right hemisphere 63.8
2587 Male, age 74, left hemisphere 59.0
1913 Female, age 42, unknown 58.5
1995 Male, age 72, unknown 55.3
Ventral tegmental area
nTPM: 60.5
2223 Female, age 72, unknown 63.8
1915 Female, age 42, unknown 61.9
1942 Male, age 51, unknown 60.0
2218 Male, age 76, both hemispheres 59.8
2410 Female, age 72, unknown 59.0
2021 Male, age 53, unknown 58.7

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 107.0
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 107.0
Samples: 139

Max nTPM: 218.7
Min nTPM: 49.8
Std nTPM: 30.9
Median nTPM: 105.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 218.7
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 171.4
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 169.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 167.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 165.9
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 162.6
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 161.2
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 157.7
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 157.6
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 155.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 149.6
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 148.6
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 145.9
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 145.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 144.9
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 144.2
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 144.1
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 141.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 141.2
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 141.1
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 140.7
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 139.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 138.7
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 137.8
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 137.2
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 136.7
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 136.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 135.5
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 134.0
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 133.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 133.2
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 132.8
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 131.1
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 130.6
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 130.4
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 127.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 126.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 126.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 124.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 124.2
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 123.1
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 123.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 122.4
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 122.2
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 121.6
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 121.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 120.5
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 120.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 118.6
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 118.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 118.0
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 118.0
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 116.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 116.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 116.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 115.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 115.1
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 114.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 114.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 114.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 113.4
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 112.7
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 111.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 111.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 109.5
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 108.0
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 107.3
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 107.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 106.9
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 105.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 105.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 105.1
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 104.7
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 104.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 103.5
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 102.7
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 101.0
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 100.0
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 99.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 99.0
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 97.8
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 97.8
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 97.0
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 96.5
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 96.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 95.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 94.2
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 94.0
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 93.9
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 93.6
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 92.6
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 91.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 90.4
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 89.3
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 89.2
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 88.9
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 88.3
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 87.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 86.5
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 86.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 85.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 85.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 85.3
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 85.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 81.4
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 81.0
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 80.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 79.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 79.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 78.4
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 77.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 76.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 76.4
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 75.6
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 74.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 74.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 71.9
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 71.0
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 70.9
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 69.7
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 69.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 68.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 68.8
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 68.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 65.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 65.2
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 65.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 64.9
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 64.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 63.0
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 62.2
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 61.2
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 60.3
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 59.1
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 58.8
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 57.7
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 56.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 52.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 49.8
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 102.2
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 102.2
FF:10158-103A5 76 years, female 102.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 30.3
Pig sample Sample description nTPM
Midbrain
nTPM: 28.8
Samples: 4

Max nTPM: 37.8
Min nTPM: 20.1
Sample A Female 20.1
Sample B Female 22.8
Sample C Male 37.8
Sample D Male 34.4
Periaqueductal gray
nTPM: 22.1
Samples: 3

Max nTPM: 25.4
Min nTPM: 19.1
Sample B Female 21.7
Sample C Male 25.4
Sample D Male 19.1
Substantia nigra
nTPM: 22.8
Samples: 4

Max nTPM: 28.3
Min nTPM: 17.0
Sample A Female 27.0
Sample B Female 18.8
Sample C Male 28.3
Sample D Male 17.0
Superior colliculi
nTPM: 30.4
Samples: 4

Max nTPM: 36.4
Min nTPM: 22.6
Sample A Female 30.3
Sample B Female 22.6
Sample C Male 36.4
Sample D Male 32.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 23.7
Mouse sample Sample description nTPM
Midbrain
nTPM: 23.7
Samples: 4

Max nTPM: 28.7
Min nTPM: 20.6
Sample A Male 28.7
Sample B Male 22.1
Sample C Female 20.6
Sample D Female 23.5

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 3.1
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 3.1
2089 Antisense, RP_Baylor_103357, Mouse strain C57BL/6J (56 days, male) 3.1
2090 Antisense, RP_Baylor_103357, Mouse strain C57BL/6J (56 days, male) 1.3

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