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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p13.2
Chromosome location (bp)
113813811 - 113871753
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
PTPN22-201
PTPN22-202
PTPN22-203
PTPN22-206
PTPN22-207
PTPN22-211
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
A0A0B4J1S7 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Protein evidence (Kim et al 2014)
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GO:0002230 [positive regulation of defense response to virus by host] GO:0002685 [regulation of leukocyte migration] GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006470 [protein dephosphorylation] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0030217 [T cell differentiation] GO:0032715 [negative regulation of interleukin-6 production] GO:0032717 [negative regulation of interleukin-8 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0034157 [positive regulation of toll-like receptor 7 signaling pathway] GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035644 [phosphoanandamide dephosphorylation] GO:0042307 [positive regulation of protein import into nucleus] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050852 [T cell receptor signaling pathway] GO:0050856 [regulation of T cell receptor signaling pathway] GO:0050868 [negative regulation of T cell activation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071225 [cellular response to muramyl dipeptide] GO:0071663 [positive regulation of granzyme B production] GO:1901222 [regulation of NIK/NF-kappaB signaling] GO:1902523 [positive regulation of protein K63-linked ubiquitination] GO:1903169 [regulation of calcium ion transmembrane transport] GO:1903753 [negative regulation of p38MAPK cascade] GO:1990782 [protein tyrosine kinase binding] GO:2000566 [positive regulation of CD8-positive, alpha-beta T cell proliferation]
E9PMT0 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
Q9Y2R2 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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Enzymes ENZYME proteins Hydrolases Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0002230 [positive regulation of defense response to virus by host] GO:0002376 [immune system process] GO:0004721 [phosphoprotein phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0004726 [non-membrane spanning protein tyrosine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0006914 [autophagy] GO:0009898 [cytoplasmic side of plasma membrane] GO:0010507 [negative regulation of autophagy] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0016791 [phosphatase activity] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0030217 [T cell differentiation] GO:0031625 [ubiquitin protein ligase binding] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032481 [positive regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0032715 [negative regulation of interleukin-6 production] GO:0032717 [negative regulation of interleukin-8 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032729 [positive regulation of interferon-gamma production] GO:0032817 [regulation of natural killer cell proliferation] GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0034157 [positive regulation of toll-like receptor 7 signaling pathway] GO:0034165 [positive regulation of toll-like receptor 9 signaling pathway] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035644 [phosphoanandamide dephosphorylation] GO:0043508 [negative regulation of JUN kinase activity] GO:0045088 [regulation of innate immune response] GO:0048471 [perinuclear region of cytoplasm] GO:0050852 [T cell receptor signaling pathway] GO:0050855 [regulation of B cell receptor signaling pathway] GO:0050856 [regulation of T cell receptor signaling pathway] GO:0050860 [negative regulation of T cell receptor signaling pathway] GO:0050868 [negative regulation of T cell activation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070433 [negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway] GO:0071225 [cellular response to muramyl dipeptide] GO:0071663 [positive regulation of granzyme B production] GO:1901222 [regulation of NIK/NF-kappaB signaling] GO:1902523 [positive regulation of protein K63-linked ubiquitination] GO:1903753 [negative regulation of p38MAPK cascade] GO:2000566 [positive regulation of CD8-positive, alpha-beta T cell proliferation]
A0A0A0MTD9 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
A0A0A0MTE6 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Protein evidence (Kim et al 2014)
F5H2S8 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 22
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Endocrine and metabolic diseases Diabetes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases