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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:97.4 nTPM
HPA:97.4 nTPM
GTEx:46.6 nTPM
FANTOM5:106.4 Scaled Tags Per Million
Pig:141.2 nTPM
Mouse:1.6 nTPM
Allen mouse:2.8 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 97.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 39.3
2586 Male, age 75, left hemisphere 64.0
2828 Female, age 72, unknown 61.8
1870 Female, age 42, unknown 53.2
1827 Male, age 72, unknown 46.1
2666 Male, age 74, left hemisphere 34.7
2411 Female, age 72, unknown 32.0
1830 Male, age 51, unknown 27.9
1833 Male, age 53, unknown 27.1
2019 Male, age 18, unknown 23.9
2219 Male, age 76, both hemispheres 22.1
Dorsal raphe nucleus
nTPM: 52.2
2016 Female, age 72, unknown 79.1
1828 Male, age 53, unknown 51.9
2298 Female, age 72, unknown 50.1
2047 Male, age 72, unknown 49.1
2750 Male, age 76, both hemispheres 31.0
Inferior colliculus
nTPM: 45.3
2097 Female, age 72, unknown 50.5
1848 Female, age 42, unknown 48.7
2849 Male, age 72, unknown 46.8
1890 Male, age 53, unknown 35.1
Median raphe nucleus
nTPM: 38.9
2220 Male, age 76, midline 38.9
Pedunculopontine tegmental nucleus
nTPM: 36.2
2338 Male, age 61, both hemispheres 54.6
2334 Male, age 80, both hemispheres 29.0
1921 Female, age 85, both hemispheres 25.0
Periaquaductal grey, anterior
nTPM: 58.0
1795 Male, age 51, unknown 89.6
2502 Female, age 75, unknown 55.1
1947 Male, age 18, unknown 29.4
Periaquaductal grey, dorsal
nTPM: 77.4
1831 Male, age 72, unknown 103.5
1840 Male, age 53, unknown 94.9
2850 Male, age 76, both hemispheres 66.8
2464 Female, age 72, unknown 44.2
Periaquaductal grey, lateral
nTPM: 97.4
2053 Male, age 18, unknown 172.2
2140 Male, age 76, both hemispheres 60.8
2272 Male, age 74, both hemispheres 59.0
Pretectal area
nTPM: 51.3
2273 Male, age 74, both hemispheres 94.7
2407 Male, age 75, both hemispheres 69.0
2825 Male, age 18, unknown 62.3
2316 Male, age 76, right hemisphere 55.7
2667 Female, age 75, unknown 53.0
2224 Female, age 72, unknown 50.2
1815 Male, age 53, unknown 49.6
1944 Female, age 72, unknown 45.1
1816 Male, age 51, unknown 33.5
1817 Female, age 42, unknown 29.4
2007 Male, age 72, unknown 21.4
Red nucleus
nTPM: 26.5
2584 Male, age 75, left hemisphere 50.9
2725 Female, age 75, unknown 41.8
2503 Female, age 72, unknown 28.9
2769 Male, age 72, unknown 25.2
2227 Male, age 72, unknown 24.7
2785 Male, age 18, unknown 24.6
2823 Male, age 76, right hemisphere 23.8
1821 Female, age 72, unknown 21.5
1865 Male, age 51, unknown 20.8
1954 Female, age 42, unknown 19.6
1904 Male, age 53, unknown 18.5
2588 Male, age 74, left hemisphere 18.3
Substantia nigra
nTPM: 38.0
2699 Male, age 18, unknown 53.5
2583 Male, age 75, right hemisphere 51.8
1941 Male, age 53, unknown 45.2
1851 Male, age 51, unknown 39.0
2590 Female, age 75, unknown 35.8
2409 Female, age 72, unknown 35.4
2241 Male, age 72, unknown 32.8
2665 Male, age 74, both hemispheres 30.9
1916 Female, age 42, unknown 28.8
1889 Female, age 72, unknown 26.4
Superior colliculus
nTPM: 59.6
2664 Male, age 75, both hemispheres 105.9
1913 Female, age 42, unknown 103.7
1995 Male, age 72, unknown 74.2
2587 Male, age 74, left hemisphere 63.8
1796 Male, age 53, unknown 59.7
1839 Male, age 51, unknown 54.0
2087 Female, age 72, unknown 48.8
2261 Male, age 18, unknown 41.2
2668 Female, age 75, unknown 23.4
1895 Male, age 76, right hemisphere 21.5
Ventral tegmental area
nTPM: 60.9
2021 Male, age 53, unknown 86.5
1915 Female, age 42, unknown 78.2
1942 Male, age 51, unknown 72.2
2223 Female, age 72, unknown 49.3
2218 Male, age 76, both hemispheres 41.7
2410 Female, age 72, unknown 37.3

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 46.6
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 46.6
Samples: 139

Max nTPM: 382.8
Min nTPM: 4.1
Std nTPM: 48.6
Median nTPM: 32.1
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 382.8
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 236.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 224.4
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 181.0
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 140.4
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 127.9
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 124.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 122.1
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 116.9
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 116.2
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 115.3
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 96.3
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 95.8
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 93.2
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 91.1
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 90.4
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 89.0
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 86.6
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 84.1
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 82.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 78.5
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 77.9
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 73.3
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 73.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 71.6
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 69.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 67.8
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 67.5
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 66.4
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 65.2
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 63.0
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 62.6
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 62.2
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 62.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 60.5
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 58.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 57.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 57.2
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 56.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 54.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 53.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 51.2
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 49.1
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 48.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 47.5
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 46.8
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 46.6
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 46.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 45.7
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 45.3
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 45.0
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 44.7
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 44.3
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 42.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 41.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 41.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 41.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 40.8
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 40.8
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 40.4
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 40.3
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 39.9
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 39.7
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 38.7
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 37.5
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 35.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 33.9
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 33.1
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 32.7
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 32.1
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 32.1
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 31.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 31.2
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 30.3
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 29.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 28.7
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 28.6
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 28.5
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 28.0
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 27.4
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 27.3
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 27.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 26.9
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 25.0
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 25.0
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 23.8
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 23.6
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 23.4
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 23.0
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 22.9
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 22.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 21.7
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 21.4
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 21.3
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 21.1
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 21.0
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 20.9
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 20.6
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 20.0
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 19.7
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 19.0
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 18.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 18.6
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 18.0
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 17.5
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 15.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 15.5
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 15.3
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 15.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 13.9
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 13.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 13.5
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 13.5
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 13.4
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 12.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 12.3
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 11.9
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 11.7
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 11.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 11.3
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 10.8
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 10.7
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 10.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 9.8
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 9.6
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 9.6
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 9.2
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 9.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 9.2
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 8.3
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 8.3
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 8.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 7.8
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 7.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 6.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 6.8
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 5.9
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 5.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 4.1
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 106.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 106.4
FF:10158-103A5 76 years, female 106.4

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 141.2
Pig sample Sample description nTPM
Midbrain
nTPM: 141.2
Samples: 4

Max nTPM: 498.6
Min nTPM: 2.3
Sample A Female 498.6
Sample B Female 2.3
Sample C Male 46.0
Sample D Male 18.0
Periaqueductal gray
nTPM: 10.3
Samples: 3

Max nTPM: 16.5
Min nTPM: 4.2
Sample B Female 4.2
Sample C Male 10.1
Sample D Male 16.5
Substantia nigra
nTPM: 56.0
Samples: 4

Max nTPM: 110.5
Min nTPM: 32.0
Sample A Female 110.5
Sample B Female 32.0
Sample C Male 37.4
Sample D Male 44.1
Superior colliculi
nTPM: 44.9
Samples: 4

Max nTPM: 83.1
Min nTPM: 13.1
Sample A Female 83.1
Sample B Female 13.1
Sample C Male 41.4
Sample D Male 42.1

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 1.6
Mouse sample Sample description nTPM
Midbrain
nTPM: 1.6
Samples: 4

Max nTPM: 1.7
Min nTPM: 1.5
Sample A Male 1.5
Sample B Male 1.7
Sample C Female 1.6
Sample D Female 1.7

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 2.8
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 2.8
1662 Antisense, RP_040507_02_F08, Mouse strain C57BL/6J (56 days, male) 2.8
1661 Antisense, RP_040507_02_F08, Mouse strain C57BL/6J (56 days, male) 1.2

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