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BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS MEDULLA OBLONGATA MIDBRAIN
OLFACTORY BULB PITUITARY GLAND PONS RETINA SPINAL CORD THALAMUS WHITE MATTER
ANTIBODIES
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VALIDATION
Brain proteome
Midbrain
MIDBRAIN - Expression summary
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units.

Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set.

If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

Read more
No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets.

The mRNA expression levels in pig are based on RNA-seq data generated by the Human Protein Atlas (HPA), and for mouse, HPA data and in situ hybridization generated by the Allen brain atlas are reported.

Scroll down to view mRNA expression data in more detail.
Read more
Consensus:129.4 nTPM
HPA:129.4 nTPM
GTEx:174.2 nTPM
FANTOM5:365.6 Scaled Tags Per Million
Pig:376.1 nTPM
Mouse:219.9 nTPM
Allen mouse:21.3 Expression energy

MIDBRAIN - HPA Brain RNA-seq
Max nTPM 129.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 105.8
2666 Male, age 74, left hemisphere 144.1
1827 Male, age 72, unknown 133.4
2019 Male, age 18, unknown 117.7
2586 Male, age 75, left hemisphere 115.5
2828 Female, age 72, unknown 103.4
1833 Male, age 53, unknown 92.4
2411 Female, age 72, unknown 91.5
2219 Male, age 76, both hemispheres 90.8
1870 Female, age 42, unknown 87.1
1830 Male, age 51, unknown 82.0
Dorsal raphe nucleus
nTPM: 79.1
2298 Female, age 72, unknown 113.4
2750 Male, age 76, both hemispheres 90.9
2047 Male, age 72, unknown 85.4
1828 Male, age 53, unknown 75.2
2016 Female, age 72, unknown 30.6
Inferior colliculus
nTPM: 107.0
2849 Male, age 72, unknown 122.2
1848 Female, age 42, unknown 120.7
2097 Female, age 72, unknown 111.8
1890 Male, age 53, unknown 73.2
Median raphe nucleus
nTPM: 129.4
2220 Male, age 76, midline 129.4
Pedunculopontine tegmental nucleus
nTPM: 92.7
1921 Female, age 85, both hemispheres 113.8
2334 Male, age 80, both hemispheres 112.6
2338 Male, age 61, both hemispheres 51.7
Periaquaductal grey, anterior
nTPM: 125.6
2502 Female, age 75, unknown 131.8
1947 Male, age 18, unknown 127.3
1795 Male, age 51, unknown 117.5
Periaquaductal grey, dorsal
nTPM: 61.9
2464 Female, age 72, unknown 71.7
1840 Male, age 53, unknown 71.0
1831 Male, age 72, unknown 56.8
2850 Male, age 76, both hemispheres 48.2
Periaquaductal grey, lateral
nTPM: 47.0
2053 Male, age 18, unknown 56.9
2140 Male, age 76, both hemispheres 48.8
2272 Male, age 74, both hemispheres 35.4
Pretectal area
nTPM: 129.0
1816 Male, age 51, unknown 192.5
1817 Female, age 42, unknown 186.5
2667 Female, age 75, unknown 185.0
1944 Female, age 72, unknown 182.9
2007 Male, age 72, unknown 170.6
1815 Male, age 53, unknown 138.1
2224 Female, age 72, unknown 94.9
2407 Male, age 75, both hemispheres 90.5
2825 Male, age 18, unknown 88.6
2316 Male, age 76, right hemisphere 51.6
2273 Male, age 74, both hemispheres 37.3
Red nucleus
nTPM: 84.8
2785 Male, age 18, unknown 117.7
2584 Male, age 75, left hemisphere 110.8
1821 Female, age 72, unknown 99.5
2588 Male, age 74, left hemisphere 90.8
1954 Female, age 42, unknown 87.2
2227 Male, age 72, unknown 86.1
2823 Male, age 76, right hemisphere 82.9
1865 Male, age 51, unknown 80.9
2769 Male, age 72, unknown 79.0
1904 Male, age 53, unknown 70.0
2503 Female, age 72, unknown 66.3
2725 Female, age 75, unknown 46.2
Substantia nigra
nTPM: 85.7
1941 Male, age 53, unknown 149.9
1889 Female, age 72, unknown 143.9
1916 Female, age 42, unknown 128.4
1851 Male, age 51, unknown 86.3
2665 Male, age 74, both hemispheres 85.3
2583 Male, age 75, right hemisphere 76.7
2241 Male, age 72, unknown 71.3
2699 Male, age 18, unknown 43.5
2409 Female, age 72, unknown 38.7
2590 Female, age 75, unknown 33.5
Superior colliculus
nTPM: 119.3
2668 Female, age 75, unknown 178.3
2087 Female, age 72, unknown 155.9
2664 Male, age 75, both hemispheres 143.2
1796 Male, age 53, unknown 142.4
2261 Male, age 18, unknown 136.3
1895 Male, age 76, right hemisphere 126.6
1839 Male, age 51, unknown 104.7
1913 Female, age 42, unknown 77.0
2587 Male, age 74, left hemisphere 76.5
1995 Male, age 72, unknown 51.9
Ventral tegmental area
nTPM: 90.9
2218 Male, age 76, both hemispheres 119.8
2410 Female, age 72, unknown 109.8
2223 Female, age 72, unknown 101.3
1915 Female, age 42, unknown 91.0
1942 Male, age 51, unknown 74.7
2021 Male, age 53, unknown 48.8

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 174.2
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 174.2
Samples: 139

Max nTPM: 647.4
Min nTPM: 65.5
Std nTPM: 86.5
Median nTPM: 155.7
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 647.4
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 526.9
GTEX-N7MS-0011-R2a-SM-2HML6 60-69 years, male 407.0
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 376.2
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 373.4
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 356.2
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 319.8
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 313.5
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 294.2
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 292.2
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 290.2
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 290.1
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 285.0
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 284.6
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 274.9
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 273.0
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 267.3
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 263.2
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 260.5
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 254.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 251.4
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 248.2
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 248.0
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 245.9
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 242.7
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 241.4
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 238.7
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 231.9
GTEX-T5JC-0011-R2A-SM-32PLZ 20-29 years, male 228.4
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 220.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 220.3
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 218.0
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 217.1
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 213.5
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 207.7
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 206.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 206.2
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 204.3
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 204.3
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 203.3
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 202.0
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 201.3
GTEX-P44G-0011-R2A-SM-2XCD2 30-39 years, male 197.6
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 195.9
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 193.4
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 191.9
GTEX-N7MT-0011-R2a-SM-2I3GI 60-69 years, female 191.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 187.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 185.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 184.7
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 184.5
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 182.5
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 180.3
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 176.9
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 176.1
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 175.4
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 170.1
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 167.6
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 166.6
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 166.0
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 164.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 163.1
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 161.6
GTEX-1IKOH-0011-R2a-SM-CMKHO 60-69 years, female 161.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 160.0
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 158.4
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 157.2
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 157.1
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 157.1
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 155.7
GTEX-OXRO-0011-R2A-SM-3NB1W 60-69 years, female 154.9
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 152.9
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 151.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 149.4
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 148.1
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 146.2
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 144.6
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 144.2
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 142.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 141.1
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 138.2
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 137.4
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 135.9
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 135.3
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 134.2
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 133.4
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 132.9
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 131.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 125.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 124.7
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 123.7
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 122.0
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 120.3
GTEX-18464-0011-R2a-SM-731AL 50-59 years, male 119.1
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 118.8
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 118.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 117.3
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 117.1
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 116.1
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 115.5
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 114.5
GTEX-NL4W-0011-R2a-SM-2I5GV 50-59 years, male 114.3
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 113.1
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 113.1
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 112.6
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 112.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 112.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 111.4
GTEX-PWO3-0011-R2A-SM-2S1OX 60-69 years, female 111.3
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 110.8
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 110.3
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 107.6
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 105.4
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 105.4
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 105.1
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 104.2
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 102.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 99.0
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 98.6
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 98.5
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 97.3
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 96.6
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 96.0
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 93.4
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 92.9
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 92.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 92.9
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 91.4
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 90.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 89.5
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 89.4
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 86.5
GTEX-NPJ8-0011-R2a-SM-2TC6M 40-49 years, male 82.5
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 80.5
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 79.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 79.1
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 71.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 70.1
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 65.5
Show allShow less

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Read more
Max Scaled Tags Per Million 365.6
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 365.6
FF:10158-103A5 76 years, female 365.6

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 376.1
Pig sample Sample description nTPM
Midbrain
nTPM: 345.7
Samples: 4

Max nTPM: 477.2
Min nTPM: 229.0
Sample A Female 269.6
Sample B Female 229.0
Sample C Male 477.2
Sample D Male 407.0
Periaqueductal gray
nTPM: 249.6
Samples: 3

Max nTPM: 292.9
Min nTPM: 225.1
Sample B Female 225.1
Sample C Male 292.9
Sample D Male 230.7
Substantia nigra
nTPM: 268.4
Samples: 4

Max nTPM: 345.5
Min nTPM: 187.5
Sample A Female 345.5
Sample B Female 187.5
Sample C Male 338.3
Sample D Male 202.2
Superior colliculi
nTPM: 376.1
Samples: 4

Max nTPM: 485.0
Min nTPM: 175.0
Sample A Female 417.4
Sample B Female 175.0
Sample C Male 485.0
Sample D Male 427.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM .

Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Read more
Average nTPM 219.9
Mouse sample Sample description nTPM
Midbrain
nTPM: 219.9
Samples: 4

Max nTPM: 240.8
Min nTPM: 196.4
Sample A Male 196.4
Sample B Male 218.2
Sample C Female 240.8
Sample D Female 224.3

MIDBRAIN - Allen Mouse ISHi

In situ hybridization (ISH) data generated by the Allen brain atlas from mouse brain is reported as expression energy. For more details about a particular experiment, click on the corresponding Allen experiment ID.

Read more
Max Expression energy 21.3
Allen experiment id Experiment description Expression energy
Midbrain
Expression energy: 21.3
385775 Antisense, RP_040625_01_E03, Mouse strain C57BL/6J (56 days, male) 21.3

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