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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q15
Chromosome location (bp)
68808177 - 68850686
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000209 [protein polyubiquitination] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097 [5S rRNA binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018215 [protein phosphopantetheinylation] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991 [protein-containing complex] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0043021 [ribonucleoprotein complex binding] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0061663 [NEDD8 ligase activity] GO:0065003 [protein-containing complex assembly] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071480 [cellular response to gamma radiation] GO:0072717 [cellular response to actinomycin D] GO:0097718 [disordered domain specific binding] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator] GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000 [amyloid fibril formation]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000209 [protein polyubiquitination] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097 [5S rRNA binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018215 [protein phosphopantetheinylation] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991 [protein-containing complex] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0043021 [ribonucleoprotein complex binding] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0061663 [NEDD8 ligase activity] GO:0065003 [protein-containing complex assembly] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071480 [cellular response to gamma radiation] GO:0072717 [cellular response to actinomycin D] GO:0097718 [disordered domain specific binding] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator] GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000 [amyloid fibril formation]
A0A0C4DFR5 [Direct mapping] Double minute 2 protein
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000209 [protein polyubiquitination] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097 [5S rRNA binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018215 [protein phosphopantetheinylation] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991 [protein-containing complex] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0043021 [ribonucleoprotein complex binding] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0061663 [NEDD8 ligase activity] GO:0065003 [protein-containing complex assembly] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071480 [cellular response to gamma radiation] GO:0072717 [cellular response to actinomycin D] GO:0097718 [disordered domain specific binding] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator] GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000 [amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000209 [protein polyubiquitination] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097 [5S rRNA binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018215 [protein phosphopantetheinylation] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991 [protein-containing complex] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0043021 [ribonucleoprotein complex binding] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0061663 [NEDD8 ligase activity] GO:0065003 [protein-containing complex assembly] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071480 [cellular response to gamma radiation] GO:0072717 [cellular response to actinomycin D] GO:0097718 [disordered domain specific binding] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator] GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000 [amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]
Metabolic proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0001568 [blood vessel development] GO:0001974 [blood vessel remodeling] GO:0002027 [regulation of heart rate] GO:0002039 [p53 binding] GO:0003170 [heart valve development] GO:0003181 [atrioventricular valve morphogenesis] GO:0003203 [endocardial cushion morphogenesis] GO:0003281 [ventricular septum development] GO:0003283 [atrial septum development] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0007507 [heart development] GO:0009636 [response to toxic substance] GO:0010039 [response to iron ion] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0010955 [negative regulation of protein processing] GO:0010977 [negative regulation of neuron projection development] GO:0016567 [protein ubiquitination] GO:0016740 [transferase activity] GO:0032026 [response to magnesium ion] GO:0033612 [receptor serine/threonine kinase binding] GO:0042220 [response to cocaine] GO:0042493 [response to drug] GO:0042802 [identical protein binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043278 [response to morphine] GO:0045202 [synapse] GO:0045472 [response to ether] GO:0045787 [positive regulation of cell cycle] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046827 [positive regulation of protein export from nucleus] GO:0046872 [metal ion binding] GO:0048545 [response to steroid hormone] GO:0051149 [positive regulation of muscle cell differentiation] GO:0060411 [cardiac septum morphogenesis] GO:0061630 [ubiquitin protein ligase activity] GO:0070301 [cellular response to hydrogen peroxide] GO:0071157 [negative regulation of cell cycle arrest] GO:0071236 [cellular response to antibiotic] GO:0071301 [cellular response to vitamin B1] GO:0071310 [cellular response to organic substance] GO:0071312 [cellular response to alkaloid] GO:0071363 [cellular response to growth factor stimulus] GO:0071375 [cellular response to peptide hormone stimulus] GO:0071391 [cellular response to estrogen stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071494 [cellular response to UV-C] GO:1904404 [response to formaldehyde] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754 [positive regulation of vascular associated smooth muscle cell migration] GO:1990785 [response to water-immersion restraint stress]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0061630 [ubiquitin protein ligase activity] GO:0071157 [negative regulation of cell cycle arrest]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Q9H4C3 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; p53 binding protein
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0042802 [identical protein binding] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0061630 [ubiquitin protein ligase activity] GO:0071157 [negative regulation of cell cycle arrest]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000209 [protein polyubiquitination] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0002039 [p53 binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0008097 [5S rRNA binding] GO:0008270 [zinc ion binding] GO:0008284 [positive regulation of cell population proliferation] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016579 [protein deubiquitination] GO:0016604 [nuclear body] GO:0016740 [transferase activity] GO:0016874 [ligase activity] GO:0016925 [protein sumoylation] GO:0018215 [protein phosphopantetheinylation] GO:0019789 [SUMO transferase activity] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030666 [endocytic vesicle membrane] GO:0031625 [ubiquitin protein ligase binding] GO:0031648 [protein destabilization] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0032991 [protein-containing complex] GO:0034504 [protein localization to nucleus] GO:0036369 [transcription factor catabolic process] GO:0042176 [regulation of protein catabolic process] GO:0042802 [identical protein binding] GO:0043021 [ribonucleoprotein complex binding] GO:0043066 [negative regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045184 [establishment of protein localization] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0047485 [protein N-terminus binding] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0051865 [protein autoubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0061663 [NEDD8 ligase activity] GO:0065003 [protein-containing complex assembly] GO:0071157 [negative regulation of cell cycle arrest] GO:0071456 [cellular response to hypoxia] GO:0071480 [cellular response to gamma radiation] GO:0072717 [cellular response to actinomycin D] GO:0097718 [disordered domain specific binding] GO:1901796 [regulation of signal transduction by p53 class mediator] GO:1901797 [negative regulation of signal transduction by p53 class mediator] GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator] GO:1990000 [amyloid fibril formation]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0005634 [nucleus] GO:0016567 [protein ubiquitination] GO:0043066 [negative regulation of apoptotic process] GO:0071157 [negative regulation of cell cycle arrest]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
F5GZB0 [Direct mapping] E3 ubiquitin-protein ligase Mdm2; MDM2 protein
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Human disease related genes Cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0016567 [protein ubiquitination]
The Human Protein Atlas project is funded
