We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p22.1
Chromosome location (bp)
6374527 - 6403967
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
RAC1-201
RAC1-202
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P63000 [Direct mapping] Ras-related C3 botulinum toxin substrate 1 A4D2P1 [Target identity:100%; Query identity:100%] Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_a; Ras-related C3 botulinum toxin substrate 1 isoform Rac1; cDNA FLJ30431 fis, clone BRACE2008968, highly similar to Ras-related C3 botulinum toxin substrate 1; cDNA FLJ75553, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1, mRNA
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding] GO:0001764 [neuron migration] GO:0001934 [positive regulation of protein phosphorylation] GO:0003376 [sphingosine-1-phosphate receptor signaling pathway] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006954 [inflammatory response] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007163 [establishment or maintenance of cell polarity] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0008045 [motor neuron axon guidance] GO:0008360 [regulation of cell shape] GO:0008361 [regulation of cell size] GO:0009611 [response to wounding] GO:0009653 [anatomical structure morphogenesis] GO:0010310 [regulation of hydrogen peroxide metabolic process] GO:0010591 [regulation of lamellipodium assembly] GO:0010592 [positive regulation of lamellipodium assembly] GO:0010595 [positive regulation of endothelial cell migration] GO:0010764 [negative regulation of fibroblast migration] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0016601 [Rac protein signal transduction] GO:0016787 [hydrolase activity] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030027 [lamellipodium] GO:0030031 [cell projection assembly] GO:0030032 [lamellipodium assembly] GO:0030036 [actin cytoskeleton organization] GO:0030041 [actin filament polymerization] GO:0030334 [regulation of cell migration] GO:0030667 [secretory granule membrane] GO:0030865 [cortical cytoskeleton organization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031410 [cytoplasmic vesicle] GO:0031529 [ruffle organization] GO:0031996 [thioesterase binding] GO:0032587 [ruffle membrane] GO:0032707 [negative regulation of interleukin-23 production] GO:0032956 [regulation of actin cytoskeleton organization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042470 [melanosome] GO:0042995 [cell projection] GO:0043197 [dendritic spine] GO:0043231 [intracellular membrane-bounded organelle] GO:0043312 [neutrophil degranulation] GO:0043652 [engulfment of apoptotic cell] GO:0044877 [protein-containing complex binding] GO:0045428 [regulation of nitric oxide biosynthetic process] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048261 [negative regulation of receptor-mediated endocytosis] GO:0048870 [cell motility] GO:0050690 [regulation of defense response to virus by virus] GO:0051022 [Rho GDP-dissociation inhibitor binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0051492 [regulation of stress fiber assembly] GO:0051496 [positive regulation of stress fiber assembly] GO:0051668 [localization within membrane] GO:0051894 [positive regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055038 [recycling endosome membrane] GO:0060071 [Wnt signaling pathway, planar cell polarity pathway] GO:0060263 [regulation of respiratory burst] GO:0070062 [extracellular exosome] GO:0071526 [semaphorin-plexin signaling pathway] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:0097178 [ruffle assembly] GO:0098794 [postsynapse] GO:0098978 [glutamatergic synapse] GO:0101003 [ficolin-1-rich granule membrane] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] GO:1902622 [regulation of neutrophil migration]
P63000 [Direct mapping] Ras-related C3 botulinum toxin substrate 1 A4D2P0 [Target identity:100%; Query identity:100%] Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1); Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1), isoform CRA_e; cDNA FLJ77333, highly similar to Homo sapiens ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) (RAC1), transcript variant Rac1b, mRNA
Show all
Enzymes ENZYME proteins Hydrolases SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Other diseases Mental and behavioural disorders Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000166 [nucleotide binding] GO:0001764 [neuron migration] GO:0001934 [positive regulation of protein phosphorylation] GO:0002551 [mast cell chemotaxis] GO:0003376 [sphingosine-1-phosphate receptor signaling pathway] GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005802 [trans-Golgi network] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005884 [actin filament] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0007015 [actin filament organization] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007163 [establishment or maintenance of cell polarity] GO:0007264 [small GTPase mediated signal transduction] GO:0007596 [blood coagulation] GO:0008045 [motor neuron axon guidance] GO:0008283 [cell population proliferation] GO:0008360 [regulation of cell shape] GO:0008361 [regulation of cell size] GO:0009611 [response to wounding] GO:0009653 [anatomical structure morphogenesis] GO:0010310 [regulation of hydrogen peroxide metabolic process] GO:0010591 [regulation of lamellipodium assembly] GO:0010592 [positive regulation of lamellipodium assembly] GO:0010595 [positive regulation of endothelial cell migration] GO:0010764 [negative regulation of fibroblast migration] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0016601 [Rac protein signal transduction] GO:0016787 [hydrolase activity] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0030027 [lamellipodium] GO:0030031 [cell projection assembly] GO:0030032 [lamellipodium assembly] GO:0030036 [actin cytoskeleton organization] GO:0030041 [actin filament polymerization] GO:0030334 [regulation of cell migration] GO:0030667 [secretory granule membrane] GO:0030865 [cortical cytoskeleton organization] GO:0031116 [positive regulation of microtubule polymerization] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031410 [cytoplasmic vesicle] GO:0031529 [ruffle organization] GO:0031996 [thioesterase binding] GO:0032587 [ruffle membrane] GO:0032707 [negative regulation of interleukin-23 production] GO:0032956 [regulation of actin cytoskeleton organization] GO:0034446 [substrate adhesion-dependent cell spreading] GO:0035025 [positive regulation of Rho protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0036464 [cytoplasmic ribonucleoprotein granule] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042470 [melanosome] GO:0042826 [histone deacetylase binding] GO:0042995 [cell projection] GO:0043197 [dendritic spine] GO:0043231 [intracellular membrane-bounded organelle] GO:0043312 [neutrophil degranulation] GO:0043652 [engulfment of apoptotic cell] GO:0044877 [protein-containing complex binding] GO:0045428 [regulation of nitric oxide biosynthetic process] GO:0045453 [bone resorption] GO:0045740 [positive regulation of DNA replication] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048013 [ephrin receptor signaling pathway] GO:0048261 [negative regulation of receptor-mediated endocytosis] GO:0048870 [cell motility] GO:0050690 [regulation of defense response to virus by virus] GO:0051022 [Rho GDP-dissociation inhibitor binding] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0051117 [ATPase binding] GO:0051492 [regulation of stress fiber assembly] GO:0051496 [positive regulation of stress fiber assembly] GO:0051668 [localization within membrane] GO:0051894 [positive regulation of focal adhesion assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0055038 [recycling endosome membrane] GO:0060071 [Wnt signaling pathway, planar cell polarity pathway] GO:0060263 [regulation of respiratory burst] GO:0070062 [extracellular exosome] GO:0071260 [cellular response to mechanical stimulus] GO:0071526 [semaphorin-plexin signaling pathway] GO:0090023 [positive regulation of neutrophil chemotaxis] GO:0097178 [ruffle assembly] GO:0098794 [postsynapse] GO:0098978 [glutamatergic synapse] GO:0101003 [ficolin-1-rich granule membrane] GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading] GO:1902622 [regulation of neutrophil migration]