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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Candidate cardiovascular disease genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q32.1
Chromosome location (bp)
206767602 - 206774541
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
IL10-202
IL10-203
IL10-205
IL10-206
IL10-207
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Human disease related genes Cardiovascular diseases Vascular diseases Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0001818 [negative regulation of cytokine production] GO:0001819 [positive regulation of cytokine production] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002237 [response to molecule of bacterial origin] GO:0002639 [positive regulation of immunoglobulin production] GO:0002719 [negative regulation of cytokine production involved in immune response] GO:0002875 [negative regulation of chronic inflammatory response to antigenic stimulus] GO:0002904 [positive regulation of B cell apoptotic process] GO:0005125 [cytokine activity] GO:0005141 [interleukin-10 receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0007568 [aging] GO:0008083 [growth factor activity] GO:0008285 [negative regulation of cell population proliferation] GO:0010033 [response to organic substance] GO:0010468 [regulation of gene expression] GO:0010507 [negative regulation of autophagy] GO:0014823 [response to activity] GO:0014854 [response to inactivity] GO:0019221 [cytokine-mediated signaling pathway] GO:0030097 [hemopoiesis] GO:0030183 [B cell differentiation] GO:0030595 [leukocyte chemotaxis] GO:0030886 [negative regulation of myeloid dendritic cell activation] GO:0030889 [negative regulation of B cell proliferation] GO:0032496 [response to lipopolysaccharide] GO:0032687 [negative regulation of interferon-alpha production] GO:0032689 [negative regulation of interferon-gamma production] GO:0032692 [negative regulation of interleukin-1 production] GO:0032695 [negative regulation of interleukin-12 production] GO:0032701 [negative regulation of interleukin-18 production] GO:0032715 [negative regulation of interleukin-6 production] GO:0032717 [negative regulation of interleukin-8 production] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032868 [response to insulin] GO:0034115 [negative regulation of heterotypic cell-cell adhesion] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0034465 [response to carbon monoxide] GO:0035722 [interleukin-12-mediated signaling pathway] GO:0035729 [cellular response to hepatocyte growth factor stimulus] GO:0042092 [type 2 immune response] GO:0042100 [B cell proliferation] GO:0042130 [negative regulation of T cell proliferation] GO:0042493 [response to drug] GO:0042742 [defense response to bacterium] GO:0042832 [defense response to protozoan] GO:0043032 [positive regulation of macrophage activation] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045019 [negative regulation of nitric oxide biosynthetic process] GO:0045191 [regulation of isotype switching] GO:0045347 [negative regulation of MHC class II biosynthetic process] GO:0045348 [positive regulation of MHC class II biosynthetic process] GO:0045787 [positive regulation of cell cycle] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046427 [positive regulation of receptor signaling pathway via JAK-STAT] GO:0046983 [protein dimerization activity] GO:0050728 [negative regulation of inflammatory response] GO:0050807 [regulation of synapse organization] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051091 [positive regulation of DNA-binding transcription factor activity] GO:0051384 [response to glucocorticoid] GO:0051930 [regulation of sensory perception of pain] GO:0060302 [negative regulation of cytokine activity] GO:0060670 [branching involved in labyrinthine layer morphogenesis] GO:0071222 [cellular response to lipopolysaccharide] GO:0071392 [cellular response to estradiol stimulus] GO:0071650 [negative regulation of chemokine (C-C motif) ligand 5 production] GO:0072577 [endothelial cell apoptotic process] GO:0097421 [liver regeneration] GO:1900100 [positive regulation of plasma cell differentiation] GO:1902895 [positive regulation of pri-miRNA transcription by RNA polymerase II] GO:1903034 [regulation of response to wounding] GO:1903208 [negative regulation of hydrogen peroxide-induced neuron death] GO:1903672 [positive regulation of sprouting angiogenesis] GO:1904057 [negative regulation of sensory perception of pain] GO:1904706 [negative regulation of vascular associated smooth muscle cell proliferation] GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation] GO:2000273 [positive regulation of signaling receptor activity] GO:2000352 [negative regulation of endothelial cell apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Cardiovascular diseases Vascular diseases Immune system diseases Allergies and autoimmune diseases Other immune system diseases Skin diseases Skin and soft tissue diseases