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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q33.2
Chromosome location (bp)
121567057 - 121785530
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
DAB2IP-201
DAB2IP-202
DAB2IP-203
DAB2IP-204
DAB2IP-205
DAB2IP-206
DAB2IP-210
DAB2IP-211
DAB2IP-212
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q5VWQ8 [Direct mapping] Disabled homolog 2-interacting protein
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0005096 [GTPase activator activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006986 [response to unfolded protein] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007252 [I-kappaB phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0007275 [multicellular organism development] GO:0008285 [negative regulation of cell population proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010596 [negative regulation of endothelial cell migration] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016525 [negative regulation of angiogenesis] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0030139 [endocytic vesicle] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0032809 [neuronal cell body membrane] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034260 [negative regulation of GTPase activity] GO:0034620 [cellular response to unfolded protein] GO:0035148 [tube formation] GO:0035591 [signaling adaptor activity] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0040008 [regulation of growth] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043254 [regulation of protein-containing complex assembly] GO:0043407 [negative regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity] GO:0044257 [cellular protein catabolic process] GO:0044300 [cerebellar mossy fiber] GO:0044301 [climbing fiber] GO:0044877 [protein-containing complex binding] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046330 [positive regulation of JNK cascade] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051721 [protein phosphatase 2A binding] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0070317 [negative regulation of G0 to G1 transition] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071158 [positive regulation of cell cycle arrest] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071889 [14-3-3 protein binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0072577 [endothelial cell apoptotic process] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090129 [positive regulation of synapse maturation] GO:1900006 [positive regulation of dendrite development] GO:1900744 [regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903363 [negative regulation of cellular protein catabolic process] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1990032 [parallel fiber] GO:1990597 [AIP1-IRE1 complex] GO:2001224 [positive regulation of neuron migration] GO:2001235 [positive regulation of apoptotic signaling pathway]
Q5VWQ8 [Direct mapping] Disabled homolog 2-interacting protein
Show all
Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0005096 [GTPase activator activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006986 [response to unfolded protein] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007252 [I-kappaB phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0007275 [multicellular organism development] GO:0008285 [negative regulation of cell population proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010596 [negative regulation of endothelial cell migration] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016525 [negative regulation of angiogenesis] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0030139 [endocytic vesicle] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0032809 [neuronal cell body membrane] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034260 [negative regulation of GTPase activity] GO:0034620 [cellular response to unfolded protein] GO:0035148 [tube formation] GO:0035591 [signaling adaptor activity] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0040008 [regulation of growth] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043254 [regulation of protein-containing complex assembly] GO:0043407 [negative regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity] GO:0044257 [cellular protein catabolic process] GO:0044300 [cerebellar mossy fiber] GO:0044301 [climbing fiber] GO:0044877 [protein-containing complex binding] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046330 [positive regulation of JNK cascade] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051721 [protein phosphatase 2A binding] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0070317 [negative regulation of G0 to G1 transition] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071158 [positive regulation of cell cycle arrest] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071889 [14-3-3 protein binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0072577 [endothelial cell apoptotic process] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090129 [positive regulation of synapse maturation] GO:1900006 [positive regulation of dendrite development] GO:1900744 [regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903363 [negative regulation of cellular protein catabolic process] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1990032 [parallel fiber] GO:1990597 [AIP1-IRE1 complex] GO:2001224 [positive regulation of neuron migration] GO:2001235 [positive regulation of apoptotic signaling pathway]
H0Y3A3 [Direct mapping] Disabled homolog 2-interacting protein
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity] GO:0007165 [signal transduction] GO:0008285 [negative regulation of cell population proliferation] GO:0016525 [negative regulation of angiogenesis] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity]
Q5VWQ8 [Direct mapping] Disabled homolog 2-interacting protein
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0001525 [angiogenesis] GO:0001933 [negative regulation of protein phosphorylation] GO:0002376 [immune system process] GO:0005096 [GTPase activator activity] GO:0005123 [death receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006986 [response to unfolded protein] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0007252 [I-kappaB phosphorylation] GO:0007257 [activation of JUN kinase activity] GO:0007275 [multicellular organism development] GO:0008285 [negative regulation of cell population proliferation] GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] GO:0010596 [negative regulation of endothelial cell migration] GO:0010633 [negative regulation of epithelial cell migration] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0010976 [positive regulation of neuron projection development] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016525 [negative regulation of angiogenesis] GO:0017124 [SH3 domain binding] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0021814 [cell motility involved in cerebral cortex radial glia guided migration] GO:0021819 [layer formation in cerebral cortex] GO:0030139 [endocytic vesicle] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031334 [positive regulation of protein-containing complex assembly] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0031435 [mitogen-activated protein kinase kinase kinase binding] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032266 [phosphatidylinositol-3-phosphate binding] GO:0032809 [neuronal cell body membrane] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034260 [negative regulation of GTPase activity] GO:0034620 [cellular response to unfolded protein] GO:0035148 [tube formation] GO:0035591 [signaling adaptor activity] GO:0035924 [cellular response to vascular endothelial growth factor stimulus] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0040008 [regulation of growth] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0042995 [cell projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043184 [vascular endothelial growth factor receptor 2 binding] GO:0043254 [regulation of protein-containing complex assembly] GO:0043407 [negative regulation of MAP kinase activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043507 [positive regulation of JUN kinase activity] GO:0043547 [positive regulation of GTPase activity] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity] GO:0044257 [cellular protein catabolic process] GO:0044300 [cerebellar mossy fiber] GO:0044301 [climbing fiber] GO:0044877 [protein-containing complex binding] GO:0045087 [innate immune response] GO:0045296 [cadherin binding] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046330 [positive regulation of JNK cascade] GO:0046580 [negative regulation of Ras protein signal transduction] GO:0048147 [negative regulation of fibroblast proliferation] GO:0048812 [neuron projection morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051721 [protein phosphatase 2A binding] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070273 [phosphatidylinositol-4-phosphate binding] GO:0070317 [negative regulation of G0 to G1 transition] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0071158 [positive regulation of cell cycle arrest] GO:0071222 [cellular response to lipopolysaccharide] GO:0071347 [cellular response to interleukin-1] GO:0071356 [cellular response to tumor necrosis factor] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071889 [14-3-3 protein binding] GO:0071901 [negative regulation of protein serine/threonine kinase activity] GO:0071902 [positive regulation of protein serine/threonine kinase activity] GO:0072577 [endothelial cell apoptotic process] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090129 [positive regulation of synapse maturation] GO:1900006 [positive regulation of dendrite development] GO:1900744 [regulation of p38MAPK cascade] GO:1900747 [negative regulation of vascular endothelial growth factor signaling pathway] GO:1901800 [positive regulation of proteasomal protein catabolic process] GO:1903363 [negative regulation of cellular protein catabolic process] GO:1903896 [positive regulation of IRE1-mediated unfolded protein response] GO:1990032 [parallel fiber] GO:1990597 [AIP1-IRE1 complex] GO:2001224 [positive regulation of neuron migration] GO:2001235 [positive regulation of apoptotic signaling pathway]
A0A3B3ITG3 [Direct mapping] Disabled homolog 2-interacting protein
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity] GO:0007165 [signal transduction] GO:0008285 [negative regulation of cell population proliferation] GO:0016525 [negative regulation of angiogenesis] GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway] GO:0038026 [reelin-mediated signaling pathway] GO:0043065 [positive regulation of apoptotic process] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity]