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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q24.21
Chromosome location (bp)
127735434 - 127742951
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MYC-201
MYC-202
MYC-203
MYC-205
MYC-206
MYC-207
MYC-208
MYC-209
MYC-210
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
P01106 [Direct mapping] Myc proto-oncogene protein A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000165 [MAPK cascade] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006112 [energy reserve metabolic process] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006879 [cellular iron ion homeostasis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0010332 [response to gamma radiation] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0015671 [oxygen transport] GO:0016579 [protein deubiquitination] GO:0019221 [cytokine-mediated signaling pathway] GO:0032204 [regulation of telomere maintenance] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0032986 [protein-DNA complex disassembly] GO:0032991 [protein-containing complex] GO:0033613 [activating transcription factor binding] GO:0034644 [cellular response to UV] GO:0035690 [cellular response to drug] GO:0042025 [host cell nucleus] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346 [fibroblast apoptotic process] GO:0044877 [protein-containing complex binding] GO:0045656 [negative regulation of monocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046983 [protein dimerization activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051276 [chromosome organization] GO:0051782 [negative regulation of cell division] GO:0051973 [positive regulation of telomerase activity] GO:0070371 [ERK1 and ERK2 cascade] GO:0070491 [repressing transcription factor binding] GO:0070848 [response to growth factor] GO:0070888 [E-box binding] GO:0071456 [cellular response to hypoxia] GO:0090096 [positive regulation of metanephric cap mesenchymal cell proliferation] GO:1904672 [regulation of somatic stem cell population maintenance] GO:1904837 [beta-catenin-TCF complex assembly] GO:1905643 [positive regulation of DNA methylation] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2001022 [positive regulation of response to DNA damage stimulus]
H0YBG3 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
H0YBT0 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
A0A087WUS5 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
A0A494C1T8 [Direct mapping] Myc proto-oncogene protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
P01106 [Direct mapping] Myc proto-oncogene protein A0A024R9L7 [Target identity:100%; Query identity:100%] Myc proto-oncogene protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Head and neck cancers Cancers of the digestive system Cancers of the lung and pleura Skin cancers Cancers of soft tissues and bone Cancers of the breast and female genital organs Cancers of male genital organs Cancers of eye, brain, and central nervous system Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000122 [negative regulation of transcription by RNA polymerase II] GO:0000165 [MAPK cascade] GO:0000785 [chromatin] GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001227 [DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003700 [DNA-binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006112 [energy reserve metabolic process] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription by RNA polymerase II] GO:0006879 [cellular iron ion homeostasis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007050 [cell cycle arrest] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell population proliferation] GO:0010332 [response to gamma radiation] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0015671 [oxygen transport] GO:0016579 [protein deubiquitination] GO:0019221 [cytokine-mediated signaling pathway] GO:0032204 [regulation of telomere maintenance] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0032986 [protein-DNA complex disassembly] GO:0032991 [protein-containing complex] GO:0033613 [activating transcription factor binding] GO:0034644 [cellular response to UV] GO:0035690 [cellular response to drug] GO:0042025 [host cell nucleus] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044346 [fibroblast apoptotic process] GO:0044877 [protein-containing complex binding] GO:0045656 [negative regulation of monocyte differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0046983 [protein dimerization activity] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048147 [negative regulation of fibroblast proliferation] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051276 [chromosome organization] GO:0051782 [negative regulation of cell division] GO:0051973 [positive regulation of telomerase activity] GO:0070371 [ERK1 and ERK2 cascade] GO:0070491 [repressing transcription factor binding] GO:0070848 [response to growth factor] GO:0070888 [E-box binding] GO:0071456 [cellular response to hypoxia] GO:0090096 [positive regulation of metanephric cap mesenchymal cell proliferation] GO:1904672 [regulation of somatic stem cell population maintenance] GO:1904837 [beta-catenin-TCF complex assembly] GO:1905643 [positive regulation of DNA methylation] GO:2000573 [positive regulation of DNA biosynthetic process] GO:2001022 [positive regulation of response to DNA damage stimulus]
The Human Protein Atlas project is funded
