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MMP13
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                                • MMP13
                                PROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA
                                Amygdala Basal ganglia Thalamus Midbrain Pons Medulla oblongata Hippocampal formation Spinal cord White matter Cerebral cortex Cerebellum Choroid plexus Hypothalamus Retina Thyroid gland Parathyroid gland Adrenal gland Pituitary gland Lung Salivary gland Esophagus Tongue Stomach Colon Rectum Small intestine Duodenum Liver Gallbladder Pancreas Kidney Urinary bladder Testis Epididymis Prostate Seminal vesicle Vagina Breast Cervix Endometrium Fallopian tube Ovary Placenta Heart muscle Skeletal muscle Smooth muscle Adipose tissue Skin Bone marrow Spleen Lymph node Tonsil Thymus Appendix
                                MMP13 INFORMATION
                                Proteini

                                Full gene name according to HGNC.

                                Matrix metallopeptidase 13
                                Gene namei

                                Official gene symbol, which is typically a short form of the gene name, according to HGNC.

                                MMP13 (CLG3)
                                Protein classi

                                Assigned HPA protein class(es) for the encoded protein(s).

                                Read more
                                Cancer-related genes
                                Disease related genes
                                Enzymes
                                Human disease related genes
                                Plasma proteins
                                Potential drug targets
                                Number of transcriptsi

                                Number of protein-coding transcripts from the gene as defined by Ensembl.

                                3
                                Protein evidence Evidence at protein level (all genes)
                                PROTEIN EXPRESSION AND LOCALIZATION
                                Tissue profilei

                                A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue section.

                                "Estimation of protein expression could not be performed. View primary data." is shown for genes where available RNA-seq and gene/protein characterization data in combination with immunohistochemistry data has been evaluated as not sufficient to yield a reliable estimation of the protein expression profile.
                                Cytoplasmic expression in chondrocytes.
                                Subcellular location Not available
                                Predicted locationi

                                All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

                                • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

                                • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

                                The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

                                Read more
                                Secreted
                                Extracellular locationi

                                All genes with at least one isoform expected to be secreted to the extracellular environment have been annotated and classified either as secreted to blood or as locally secreted, depending on the predicted final location of the corresponding protein. Proteins expected to be locally secreted have been further classified according to their site of expression.

                                Read more
                                Secreted to extracellular matrix
                                TISSUE RNA EXPRESSION
                                Tissue specificityi

                                The RNA specificity category is based on normalized mRNA expression levels in the consensus dataset, calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.

                                Read more
                                Tissue enriched (urinary bladder)
                                Cerebral cortexCerebellumChoroid plexusBasal gangliaThalamusHypothalamusMidbrainPonsMedulla oblongataHippocampal formationSpinal cordWhite matterAmygdalaRetinaThyroid glandParathyroid glandAdrenal glandPituitary glandLungSalivary glandEsophagusTongueStomachDuodenumSmall intestineColonRectumLiverGallbladderPancreasKidneyUrinary bladderTestisEpididymisSeminal vesicleProstateVaginaOvaryFallopian tubeEndometriumCervixPlacentaBreastHeart muscleSmooth muscleSkeletal muscleAdipose tissueSkinAppendixSpleenLymph nodeTonsilBone marrowThymus02468101214
                                Basal respiratory cellsClub cellsIonocytesRespiratory ciliated cellsMucus glandular cellsSerous glandular cellsGastric mucus-secreting cellsProximal enterocytesPaneth cellsDistal enterocytesIntestinal goblet cellsExocrine glandular cellsBasal prostatic cellsProstatic glandular cellsBreast glandular cellsBreast myoepithelial cellsEndometrial ciliated cellsGlandular and luminal cellsBasal keratinocytesSuprabasal keratinocytesBasal squamous epithelial cellsSquamous epithelial cellsAlveolar cells type 1Alveolar cells type 2Salivary duct cellsDuctal cellsHepatocytesCholangiocytesProximal tubular cellsDistal tubular cellsCollecting duct cellsThymic epithelial cellsSertoli cellsGranulosa cellsEnteroendocrine cellsPancreatic endocrine cellsLeydig cellsTheca cellsExcitatory neuronsInhibitory neuronsCone photoreceptor cellsRod photoreceptor cellsBipolar cellsHorizontal cellsAstrocytesOligodendrocyte precursor cellsOligodendrocytesMicroglial cellsMuller glia cellsSchwann cellsSpermatogoniaSpermatocytesEarly spermatidsLate spermatidsCytotrophoblastsSyncytiotrophoblastsExtravillous trophoblastsEndothelial cellsCardiomyocytesSkeletal myocytesSmooth muscle cellsAdipocytesMelanocytesFibroblastsPeritubular cellsEndometrial stromal cellsUndifferentiated cellsT-cellsB-cellsPlasma cellsNk-cellsGranulocytesMonocytesMacrophagesHofbauer cellsKupffer cellsDendritic cellsLangerhans cellsErythroid cells0100200300400
                                Tissue expression clusteri

                                The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Smooth muscle tissue - Mixed function (mainly)
                                Brain specificityi

                                The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category

                                Read more
                                Not detected in human brain
                                Single cell type specificityi

                                The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

                                Read more
                                Cell type enriched (Basal respiratory cells)
                                Single cell type
                                expression clusteri

                                The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Bronchus - Unknown function (mainly)
                                Tissue cell type classificationi

                                Genes can have enriched specificity in different cell types in one or several tissues, or be enriched in a core cell type that appears in many different tissues.

                                Read more
                                Cell type enriched (Prostate - Urothelial cells)
                                IMMUNE CELLS
                                Immune cell specificityi

                                The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

                                Read more
                                Not detected in immune cells
                                BasophilEosinophilNeutrophilClassical monocyteNon-classical monocyteIntermediate monocyteT-regGdT-cellMAIT T-cellMemory CD4 T-cellNaive CD4 T-cellMemory CD8 T-cellNaive CD8 T-cellMemory B-cellNaive B-cellPlasmacytoid DCMyeloid DCNK-cellTotal PBMC0246810
                                Immune cell
                                expression clusteri

                                The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Basophils - Unknown function (mainly)
                                CANCER & CELL LINES
                                Prognostic summary Gene product is not prognostic
                                Bile duct cancerBladder cancerBone cancerBrain cancerBreast cancerCervical cancerColorectal cancerUterine cancerEsophageal cancerGallbladder cancerGastric cancerHead and Neck cancerKidney cancerLeukemiaLiver cancerLung cancerLymphomaMyelomaNeuroblastomaNon-cancerousOvarian cancerPancreatic cancerProstate cancerRhabdoidSarcomaSkin cancerTestis cancerThyroid cancerUncategorized0102030405060
                                Cancer specificityi

                                Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

                                Read more
                                Cancer enhanced (head and neck cancer)
                                Cell line
                                expression clusteri

                                The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

                                Read more
                                Keratinocytes - Epithelial cell function (mainly)
                                Cell line specificityi

                                RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

                                Read more
                                Cancer enhanced (Head and neck cancer, Thyroid cancer)
                                PROTEINS IN BLOOD
                                Upregulated in diseasei

                                A gene is classified as upregulated in a disease if the average concentration of all samples of that disease is significantly higher (adj P-value<0.05) than the average concentration of samples of all diseases as measured by PEA . For gender specific diseases the analysis includes only samples corresponding to the same gender from the other diseases.

                                Acute myeloid leukemia, Myeloma
                                -0.8-0.6-0.4-0.200.20.40.60.811.21.41.61.8Colorectal cancerBreast cancerCervical cancerEndometrial cancerOvarian cancerGliomaMyelomaAcute myeloid leukemiaChronic lymphocytic leukemiaDiffuse large B-cell lymphomaLung cancerProstate cancer
                                Disease prediction modeli

                                The disease(s) the gene is associated with and able to predict according to glmnet prediction models. To be included the gene has to be upregulated according to differential expression analysis and have more than 50% overall importance as indicated by the prediction models.

                                No
                                Secretome annotationi

                                All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are:

                                • secreted into blood
                                • locally secreted
                                • or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.

                                Read more
                                Secreted to extracellular matrix
                                Detected in blood by
                                immunoassayi

                                The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.

                                Read more
                                No (not applicable)
                                Detected in blood by
                                mass spectrometryi

                                Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.

                                No
                                Detected in blood by
                                proximity extension assayi

                                Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years.

                                Read more
                                Yes
                                PROTEIN FUNCTION
                                Protein function (UniProt)i

                                Useful information about the protein provided by UniProt.

                                Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.... show less
                                Molecular function (UniProt)i

                                Keywords assigned by UniProt to proteins due to their particular molecular function.

                                Hydrolase, Metalloprotease, Protease
                                Biological process (UniProt)i

                                Keywords assigned by UniProt to proteins because they are involved in a particular biological process.

                                Collagen degradation
                                Disease involvementi

                                Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets

                                Read more
                                Cancer-related genes, Disease variant, Dwarfism
                                Ligand (UniProt)i

                                Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.

                                Calcium, Metal-binding, Zinc
                                Gene summary (Entrez)i

                                Useful information about the gene from Entrez

                                This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]... show less

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